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Enalapril

Enac, Enalapril, Enalaprilmaleat Alternova, Mepril · ATC code C09AA02

Also known as: Enalapril Maleate · Brand names: Enac, Enalaprilmaleat Alternova, Mepril, Renistad, Renitec, Corvo, Enalaprilmaleat Al, Xanef, Enapress, Enapril, Ketansif, Konveril, Epaned, Vasotec

Key facts
Active substance
Enalapril
Drug class
ACE inhibitor
ATC code
C09AA02
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-29

Boxed warning

See full prescribing information for complete boxed warning.

• When pregnancy is detected, discontinue Enalapril Maleate Tablets as soon as possible.

• Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (See WARNINGS, Fetal Toxicity.)

Key facts

Enalapril is an ACE inhibitor. Per the US prescribing information, it is used for hypertension, symptomatic heart failure and asymptomatic left ventricular dysfunction.

What it is used for

  • Hypertension, alone or in combination, especially with thiazide-type diuretics
  • Symptomatic congestive heart failure, usually with diuretics and digitalis
  • Asymptomatic left ventricular dysfunction (ejection fraction ≤35 percent) to decrease the development of overt heart failure

Dosing

  • Hypertension without a diuretic: start with 5 mg once a day; usual range 10 to 40 mg per day in one or two doses
  • On a diuretic: if possible stop it two to three days before; otherwise start with 2.5 mg under medical supervision
  • Creatinine clearance ≤30 mL/min: first dose 2.5 mg once daily, titrated up to a maximum of 40 mg daily; dialysis patients 2.5 mg on dialysis days
  • Heart failure: start with 2.5 mg; dosing range 2.5 to 20 mg twice a day; with hyponatremia or elevated creatinine start with 2.5 mg daily under close supervision
  • Asymptomatic left ventricular dysfunction: start with 2.5 mg twice daily, target 20 mg daily in divided doses
  • Pediatric hypertension: start with 0.08 mg/kg (up to 5 mg) once daily; not recommended in neonates or with GFR below 30 mL/min/1.73 m²

Contraindications

  • Hypersensitivity to this product
  • History of angioedema with prior ACE inhibitor treatment, and hereditary or idiopathic angioedema
  • Coadministration with aliskiren in patients with diabetes
  • Combination with a neprilysin inhibitor (e.g. sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan

Important warnings

  • Boxed warning: fetal toxicity – drugs acting on the renin-angiotensin system can injure and kill the developing fetus; discontinue as soon as possible when pregnancy is detected
  • Head and neck angioedema may occur at any time and can be fatal with laryngeal involvement; discontinue promptly
  • Symptomatic hypotension, particularly after the first dose in patients on diuretics
  • Hyperkalemia, especially with potassium supplements, salt substitutes or potassium-sparing diuretics
  • Persistent nonproductive cough, presumably from bradykinin, may occur

Side effects

  • Headache (5.2%), dizziness (4.3%), fatigue (3.0%)
  • Diarrhea, nausea, rash (1.4% each), cough (1.3%), orthostatic effects (1.2%)
  • Hypotension, hyperkalemia, angioedema

Interactions

  • Diuretics: enhanced blood pressure fall at the start of therapy
  • Potassium supplements, potassium salt substitutes, potassium-sparing diuretics: rise in serum potassium
  • Aliskiren and neprilysin inhibitors (see contraindications)
  • Lithium: lithium toxicity reported

Pregnancy and breastfeeding

  • Discontinue as soon as possible when pregnancy is detected; can injure and kill the developing fetus

Summary of the official product information, written with AI on 2026-10-29. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • EnacHexal Pharma Gmbh · 1 register entry
  • Enalapril1a Pharma Gmbh, Teva B.V, Genericon Pharma Gesellschaft M.B.H., +pharma Arzneimittel Gmbh, Sandoz Gmbh, G.L. Pharma Gmbh · 7 register entries
  • Enalaprilmaleat AlternovaKrka, D.D., Novo Mesto · 1 register entry
  • MeprilKwizda Pharma Gmbh · 1 register entry
  • RenistadStada Arzneimittel Gmbh · 1 register entry
  • RenitecOrganonhealthcare Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Germany

  • CorvoTad Pharma Gmbh · 1 register entry
  • Enalapril089pharm Gmbh, 1 A Pharma Gmbh, Ratiopharm Gmbh, Vitabalans Oy, Stadapharm Gmbh, Abz-Pharma Gmbh · 7 register entries
  • Enalaprilmaleat AlAliud Pharma Gmbh · 1 register entry
  • XanefOrganonhealthcare Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Turkey

  • EnapressMENARİNİ SAĞLIK VE İLAÇ SAN. TİC. A.Ş. · 2 register entries
  • EnaprilSANDOZ İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
  • KetansifULKAR KİMYA SAN. VE TİC. A.Ş. · 3 register entries
  • KonverilNOBEL İLAÇ SAN. VE TİC. A.Ş. · 8 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • EpanedAzurity Pharmaceuticals, Inc. · 1 register entry
  • VasotecBausch Health US LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-29

Brand names in 28 more European countries
Belgium
Enalapril Eg, Enalapril Sandoz, Renitec
Bulgaria
Eнап, Вазопрен, Еналаприл Чайкафарма, Енприл, Ренаприл, Ренитек
Croatia
Enap
Cyprus
Istopril, Korandil
Czechia
Enalapril Vitabalans, Enap, Enapril
Denmark
Corodil, Enacodan, Enalapril "sandoz", Enalapril Accord, Enalapril Krka, Enalapril Teva, Enalapril Vitabalans
Estonia
Enahexal, Enalapril Vitabalans, Enap
Finland
Enalapril Krka, Enalapril Orion, Enalapril Ratiopharm, Enalapril Vitabalans, Linatil, Linatilsan, Renitec
France
Enalapril Accord, Enalapril Arrow Lab, Enalapril Biogaran, Enalapril Eg, Enalapril Evolugen, Enalapril Sandoz, Enalapril Teva, Enalapril Viatris, Enalapril Zentiva, Renitec
Greece
Analept, Kaparlon-S, Renitec, Ulticadex
Hungary
Ednyt, Enalapril Vitabalans, Renitec
Iceland
Aqumeldi, Daren, Enalapril Krka
Ireland
Enalapril Maleate Accord, Enap, Innovace
Italy
Converten, Enalapril Almus, Enalapril Aurobindo Pharma Italia, Enalapril Doc, Enalapril Eg, Enalapril Mylan Generics, Enalapril Pensa, Enalapril Sandoz, Enalapril Teva Italia, Enalapril Zentiva, Enapren, Lanex, Naprilene
Latvia
Enahexal, Enalapril Vitabalans, Enap, Enarenal
Liechtenstein
Aqumeldi
Lithuania
Enahexal, Enalapril Vitabalans, Enap, Enarenal
Luxembourg
Enalapril Eg, Renitec
Malta
Korandil
Netherlands
Enalapril Maleate Aurobindo, Enalapril Maleate Viatris, Enalapril Teva, Enalaprilmaleaat Accord, Enalaprilmaleaat Hexal Ag, Enalaprilmaleaat Nevik, Enalaprilmaleaat Sandoz, Enalaprilmaleaat Teva, Renitec
Norway
Aqumeldi, Enalapril Krka, Enalapril Sandoz, Renitec
Poland
Enalapril Vitabalans, Enarenal
Portugal
Cetampril, Enalapril Accord, Enalapril Bluepharma, Enalapril Ciclum, Enalapril Farmoz, Enalapril Generis, Enalapril Krka, Enalapril Ratiopharm, Enalapril Sandoz, Enalapril Vitória, Maleato De Enalapril Mylan, Prilan, Renitec, Vasotil
Romania
Enalapril Arena, Enalapril Laropharm, Enalapril Lph Labormed, Enalapril Magistra C&c, Enalapril Slavia, Enalapril Terapia, Enalapril Vim Spectrum, Enap, Renitec
Slovakia
Enalapril Vitabalans, Enap
Slovenia
Enalapril Vitabalans, Enap, Olivin
Spain
Acetensil, Baripril, Dabonal, Enalapril Alter, Enalapril Aurovitas, Enalapril Bd-Mabo, Enalapril Belmac, Enalapril Cinfa, Enalapril Davur, Enalapril Durbán, Enalapril Kern Pharma, Enalapril Maleato Uxa Farma S.A., Enalapril Normon, Enalapril Pensa, Enalapril Qualigen, Enalapril Sandoz, Enalapril Stada, Enalapril Tarbis, Enalapril Teva-Ratiopharm, Enalapril Viatris, Enalapril Vir, Herten, Naprilene, Renitec
Sweden
Enalapril Accord, Enalapril Krka, Enalapril Orion, Enalapril Sandoz, Enalapril Stada, Enalapril Teva, Enalapril Vitabalans, Renitec

EMA – Article 57 product data (EU/EEA), 2026-10-29

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Enalapril Maleate (OCEANSIDE PHARMACEUTICALS) – Prescribing Information, 2020-12-01. DailyMed (NLM), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ebd2a62d-a704-4f8a-a104-749a5296502f
  2. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC C09AA.

Editorial: Medelix editorial team · last updated 2026-10-29 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.