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Lisinopril

Acemin, Acetan, Lisinopril, Lisinostad · ATC code C09AA03

Brand names: Acemin, Acetan, Lisinostad, Lino, Lisi, Lisihexal, Lisip, April-Ace, Rilace, Sinopryl, Tanstop

Key facts
Active substance
Lisinopril
Drug class
ACE inhibitor
ATC code
C09AA03
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Boxed warning

  • When pregnancy is detected, discontinue lisinopril as soon as possible [see Warnings and Precautions (5.1)].
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see Warnings and Precautions (5.1) ].

Key facts

Lisinopril is an ACE inhibitor. Per the US label it is used for hypertension, heart failure and reduction of mortality after acute myocardial infarction.

What it is used for

  • Hypertension in adults and children 6 years of age and older
  • Systolic heart failure (adjunct to diuretics and usually digitalis)
  • Reduction of mortality in acute myocardial infarction in haemodynamically stable patients

Dosing

  • Hypertension: initial dose 10 mg once a day, usual range 20 mg to 40 mg per day; with a diuretic start at 5 mg
  • Children 6 years and older: 0.07 mg per kg once daily (up to 5 mg) initially, maximum 0.61 mg per kg (up to 40 mg)
  • Heart failure: start 5 mg once daily (2.5 mg with hyponatraemia), maximum 40 mg
  • Acute MI: 5 mg, then 5 mg after 24 hours, 10 mg after 48 hours, then 10 mg once daily for at least six weeks
  • Creatinine clearance 10 to 30 mL/min: half the usual initial dose; haemodialysis or below 10 mL/min: start 2.5 mg

Contraindications

  • Combination with a neprilysin inhibitor (e.g. sacubitril); 36 hours apart when switching
  • History of angioedema or hypersensitivity with a previous ACE inhibitor; hereditary or idiopathic angioedema
  • Aliskiren in patients with diabetes

Important warnings

  • Boxed warning: fetal toxicity – discontinue as soon as possible when pregnancy is detected
  • Angioedema (including fatal cases); higher risk with mTOR or neprilysin inhibitors
  • Hypotension, especially with volume depletion or diuretics
  • Hyperkalaemia and worsening renal function may occur

Side effects

  • Hypertension trials: headache, dizziness, cough
  • Heart failure trials: hypotension, chest pain
  • Angioedema can occur at any time during treatment, including fatal cases

Interactions

  • Diuretics: excessive blood pressure drop at initiation; potassium-sparing diuretics increase hyperkalaemia risk
  • Antidiabetics: increased glucose-lowering effect with risk of hypoglycaemia
  • Neprilysin and mTOR inhibitors: higher angioedema risk; do not combine aliskiren in diabetes

Pregnancy and breastfeeding

  • Can cause fetal harm, especially in the second and third trimesters; discontinue as soon as possible when pregnancy is detected

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • AceminAtnahs Pharma Netherlands B.V. · 1 register entry
  • AcetanKwizda Pharma Gmbh · 1 register entry
  • Lisinopril1a Pharma Gmbh, Sandoz Gmbh, Kwizda Pharma Gmbh, Teva B.V, Taw Pharma (Ireland) Ltd, Genericon Pharma Gesellschaft M.B.H., Actavis Group Ptc Ehf. · 9 register entries
  • LisinostadStada Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • LinoRatiopharm Gmbh · 2 register entries
  • LisiHennig Arzneimittel Gmbh & Co. Kg, Winthrop Arzneimittel Gmbh · 3 register entries
  • LisihexalHexal Ag · 1 register entry
  • Lisinopril1 A Pharma Gmbh, Ratiopharm Gmbh, Heumann Pharma Gmbh & Co. Generica Kg, Holsten Pharma Gmbh, Puren Pharma Gmbh & Co. Kg, Stadapharm Gmbh, Teva Gmbh, Abz-Pharma Gmbh, Aliud Pharma Gmbh · 12 register entries
  • LisipRatiopharm Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • April-AceBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • RilaceSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 4 register entries
  • SinoprylSANOFİ SAĞLIK ÜRÜNLERİ LTD. ŞTİ. · 3 register entries
  • TanstopNOBEL İLAÇ SAN. VE TİC. A.Ş. · 3 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 26 more European countries
Belgium
Lisinopril Eg, Lisinopril Grindeks, Lisinopril Sandoz, Lisinopril Taw Pharma, Lisinopril Teva, Zestril
Bulgaria
Витоприл, Диротон, Кордакер, Лизиноприл Софарма, Лизоприл, Линиприл, Скоприл
Croatia
Amicor, Irumed, Optimon, Skopryl
Cyprus
Albigone, Dapril, Zestril
Czechia
Dapril, Diroton
Denmark
Cardiostad, Lisinopril Actavis, Lisinopril Viatris, Lisopress
Estonia
Lisinopril Grindek,s, Lisinopril Grindeks
Finland
Cardiostad, Lisinopril Grindeks, Lisinopril Orion, Lisinopril Ratiopharm
France
Lisinopril Arrow, Lisinopril Biogaran, Lisinopril Eg, Lisinopril Grindeks, Lisinopril Sandoz, Lisinopril Teva, Lisinopril Viatris, Lisinopril Zentiva, Zestril
Greece
Adicanil, Leruze, Lisinopril Grindeks, Nafordyl, Perenal, Pressamea, Pressuril, Vercol, Veroxil, Z-Bec, Zestril
Hungary
Lisinopril Grindeks, Lisopress
Ireland
Lestace, Lisinopril Grindeks, Lisinopril Taw Pharma (Ireland), Lisopress, Lispril, Zestan, Zestril
Italy
Alapril, Lisinopril Aurobindo, Lisinopril Doc Generici, Lisinopril Eg, Lisinopril Grindeks, Lisinopril Mylan Generics, Lisinopril Pensa, Lisinopril Ratiopharm, Lisinopril Sandoz, Lisinopril Zentiva, Prinivil, Zestril
Latvia
Lisinopril Grindeks
Lithuania
Diroton
Luxembourg
Lisinopril Eg, Lisinopril Ratiopharm, Lisinopril Taw Pharma, Zestril
Malta
Dapril, Lisinopril Accord Healthcare, Lisinopril Aurobindo, Zestril
Netherlands
Lisinopril Accord, Lisinopril Aurobindo, Lisinopril Dihydrate Aurobindo, Lisinopril Genrx, Lisinopril Lisinopril Taw Pharma, Lisinopril Mylan, Lisinopril Sandoz, Lisinopril Teva, Lisinopril Viatris
Norway
Lisinopril Ratiopharm, Lisinopril Taw Pharma, Zestril
Poland
Lisihexal, Lisinopril Aurovitas, Lisinopril Grindeks, Lisinoratio, Lisiprol, Ranopril
Portugal
Ecapril, Lipril, Lisinopril Aurovitas, Lisinopril Basi, Lisinopril Bluepharma, Lisinopril Ciclum, Lisinopril Generis, Lisinopril Germed, Lisinopril Gp, Lisinopril Grindeks, Lisinopril Ratiopharm, Lisinopril Sandoz, Lisinopril Teva, Lisinopril Tolife, Lisinopril Zentiva, Zestril
Romania
Lisinopril Atb, Lisinopril Sandoz, Lisiren, Ranolip, Tonolysin
Slovakia
Dapril, Diroton, Irumed, Lisinopril Ratiopharm
Slovenia
Irumed, Skopryl
Spain
Doneka, Lisinopril Aurovitas, Lisinopril Cinfa, Lisinopril Normon, Lisinopril Qualigen, Lisinopril Sandoz Farmaceutica, Lisinopril Stada, Lisinopril Teva-Ratiopharm, Lisinopril Viatris, Prinivil, Zestril
Sweden
Lisiliv, Lisinopril Actavis, Lisinopril Stada, Zestril

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. U.S. Food and Drug Administration. Lisinopril (Aurobindo Pharma Limited) – Prescribing Information, 2026-07-21. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0e6364a4-6d66-4151-8197-d45e2a762895
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC C09AA.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.