RIFLE criteria
Nephrology and urology
Also known as: RIFLE-Kriterien (akute Nierenschädigung) · RIFLE kriterleri · RIFLE criteria for acute kidney injury (ADQI 2004)
What it is for
RIFLE (Risk, Injury, Failure, Loss, End-stage kidney disease) grades acute kidney dysfunction by serum creatinine (SCr) or glomerular filtration rate (GFR) change from baseline, or by urine output (UO); the worse criterion sets the class. The change should be abrupt (1–7 days) and sustained (>24 hours).
Classification
| Category | Description |
|---|---|
| Risk | SCr ×1.5 or GFR decrease >25%; or UO <0.5 ml/kg/h for 6 hours. |
| Injury | SCr ×2 or GFR decrease >50%; or UO <0.5 ml/kg/h for 12 hours. |
| Failure | SCr ×3, or GFR decrease >75%, or SCr ≥4 mg/dl (≥354 µmol/l) with an acute rise of ≥0.5 mg/dl (44 µmol/l); or UO <0.3 ml/kg/h for 24 hours, or anuria for 12 hours. RIFLE-FC marks acute-on-chronic failure reached by the 4 mg/dl criterion, RIFLE-FO failure reached by the urine output criterion. |
| Loss | persistent acute renal failure: complete loss of kidney function (need for renal replacement therapy) for more than 4 weeks. |
| End-stage kidney disease (E) | need for dialysis for more than 3 months. |
Source
Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
ADQI · Crit Care 2004;8:R204–R212 (Bellomo R et al.)
DOI: 10.1186/cc2872
PMID: 15312219
- Edition
- ADQI 2004 (RIFLE); superseded for staging by KDIGO 2012, still used in studies
- Checked on
Summary of the published classification in our own words. Not a substitute for the original publication.
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