Gleason score and ISUP grade groups
Nephrology and urology
Also known as: Gleason-Score und ISUP-Graduierungsgruppen · Gleason skoru ve ISUP derece grupları · Gleason score and ISUP grade groups (prostate cancer)
What it is for
Histological grading of prostatic adenocarcinoma. Gleason patterns run from 1 (well formed glands) to 5 (no gland formation); in practice patterns 3–5 are assigned. The Gleason score adds the most common (primary) and the second most common or highest (secondary) pattern, e.g. 3+4=7. ISUP 2014 compresses the scores into five grade groups.
Classification
| Category | Description |
|---|---|
| Grade group 1 | Gleason score ≤6 (3+3). |
| Grade group 2 | Gleason score 3+4=7. |
| Grade group 3 | Gleason score 4+3=7. |
| Grade group 4 | Gleason score 8 (4+4, 3+5 or 5+3). |
| Grade group 5 | Gleason score 9–10 (4+5, 5+4, 5+5). |
| Notation | Both the Gleason score and the grade group are reported, e.g. "Gleason 3+4=7 (ISUP grade group 2)". |
| ISUP 2019 update | adds reporting of the percentage of pattern 4, of invasive cribriform growth and of intraductal carcinoma (ISUP grades intraductal carcinoma together with the invasive tumour; the Genitourinary Pathology Society 2019 grades the invasive component only). The five grade groups are unchanged. |
Source
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System
ISUP · Am J Surg Pathol 2016;40:244–252 (Epstein JI et al.)
DOI: 10.1097/PAS.0000000000000530
PMID: 26492179
- Edition
- ISUP 2014 grade groups (adopted in WHO 2016 and retained in the WHO 5th edition 2022); ISUP 2019 update refines reporting
- Checked on
Summary of the published classification in our own words. Not a substitute for the original publication.
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