clopidogrel
Clopidogrel Zentiva (previously Clopidogrel Winthrop), Iscover, Plavix · ATC code B01AC04
Brand names: Clopidogrel Zentiva, Iscover, Plavix, Aclop, Clopipuren, Plavocorin, Zopya, As-Clodip, Atervix, Cardogrel, Clogan, Cloperol, Clopitro, Clopra, Diloxol …
- Key facts
- Active substance
- clopidogrel
- Drug class
- Antithrombotic
- ATC code
- B01AC04
- Authorisation
- centrally authorised across the EU (EMA)
- Dosage forms
- Clopidogrel Zentiva 75 mg film-coated tablets · Iscover 75 mg film-coated tablets / Iscover 300 mg film-coated tablets · Plavix 75 mg film-coated tablets / Plavix 300 mg film-coated tablets
- Marketing authorisation holder
- Zentiva k.s., Sanofi Winthrop Industrie
- Information as of
- 2026-10-27
Key facts
Clopidogrel is an antiplatelet agent (P2Y12 inhibitor). It is used to prevent atherothrombotic events after myocardial infarction or stroke, in peripheral arterial disease and in acute coronary syndrome.
What it is used for
- Secondary prevention after myocardial infarction, ischaemic stroke or in established peripheral arterial disease (adults)
- Acute coronary syndrome (NSTE-ACS and STEMI) in combination with acetylsalicylic acid (ASA), including stent placement
- Moderate to high-risk TIA or minor ischaemic stroke: with ASA, started within 24 hours
- Atrial fibrillation: prevention of atherothrombotic and thromboembolic events (details in the full text)
Dosing
- Adults and elderly: 75 mg once daily
- NSTE-ACS: single 300 mg or 600 mg loading dose, then 75 mg daily with ASA (ASA dose not higher than 100 mg recommended)
- STEMI, medically treated: 300 mg loading dose, then 75 mg daily; patients over 75 years start without a loading dose
- The 300 mg tablet is intended for use as a loading dose
- Limited experience in renal impairment and moderate hepatic disease; not to be used in children
- Further regimens (TIA, atrial fibrillation, PCI) in the full text
Contraindications
- Hypersensitivity to the active substance or excipients
- Severe hepatic impairment
- Active pathological bleeding such as peptic ulcer or intracranial haemorrhage
Important warnings
- Bleeding risk, especially with trauma, surgery or other medicines that increase bleeding
- Triple antiplatelet therapy (clopidogrel + ASA + dipyridamole) not recommended in acute non-cardioembolic ischaemic stroke or TIA
- Thrombotic thrombocytopenic purpura (TTP) reported very rarely, sometimes after short exposure
- Reduced effect possible in CYP2C19 poor metabolisers
Side effects
- Bleeding is the most common reaction, mostly reported in the first month of treatment
- Other adverse reactions by frequency in the full text
Interactions
- Oral anticoagulants: concomitant use not recommended (may increase bleeding intensity)
- Caution with ASA, heparin, glycoprotein IIb/IIIa inhibitors, NSAIDs and SSRIs
- Strong or moderate CYP2C19 inhibitors (e.g. omeprazole, esomeprazole, fluvoxamine, fluoxetine, fluconazole) should be discouraged
Pregnancy and breastfeeding
- Preferably not used during pregnancy as a precaution
- Breast-feeding should not be continued during treatment
Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
Common questions – ask Medelix
For patients
Package leaflet, verbatim
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
EU – centrally authorised (all member states)
- Clopidogrel BGR (previously Zylagren) · genericBiogaran · EMEA/H/C/001138
- Clopidogrel HCS · genericHCS bvba · EMEA/H/C/002255
- Clopidogrel Krka · genericKrka, d.d., Novo mesto · EMEA/H/C/001056
- Clopidogrel Krka d.d. (previously Zopya) · genericNorpharm Regulatory Services Ltd · EMEA/H/C/001137
- Clopidogrel ratiopharm · genericTeva B.V. · EMEA/H/C/004006
- Clopidogrel TAD · genericTad Pharma GmbH · EMEA/H/C/001136
- Clopidogrel Taw Pharma (previously Clopidogrel Mylan) · genericTaw Pharma (Ireland) Limited · EMEA/H/C/001134
- Clopidogrel Teva (hydrogen sulphate) · genericTeva Pharma B.V. · EMEA/H/C/001053
- Clopidogrel Viatris (previously Clopidogrel Taw Pharma) · genericViatris Limited · EMEA/H/C/001189
- Clopidogrel Zentiva (previously Clopidogrel Winthrop)Zentiva k.s. · EMEA/H/C/000975
- Grepid · genericPharmathen S.A. · EMEA/H/C/001059
- IscoverSanofi Winthrop Industrie · EMEA/H/C/000175
Source: European Medicines Agency (EMA), product information
Austria
- AclopG.L. Pharma Gmbh · 1 register entry
- Clopidogrel1a Pharma Gmbh, Genericon Pharma Gesellschaft M.B.H., +pharma Arzneimittel Gmbh, Actavis Group Ptc Ehf., Accord Healthcare B.V., Sandoz Gmbh, Stada Arzneimittel Gmbh, G.L. Pharma Gmbh · 8 register entries
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Germany
- ClopidogrelAaa-Pharma Gmbh, 1 A Pharma Gmbh, Hexal Ag, Puren Pharma Gmbh & Co. Kg, Hec Pharm Gmbh, Medical Valley Invest Ab, Bluefish Pharmaceuticals Ab, Glenmark Arzneimittel Gmbh, Heumann Pharma Gmbh & Co. Generica Kg, Vivanta Generics S.R.O., Amarox Pharma Gmbh, Aristo Pharma Gmbh (Art 57), Basics Gmbh, Stadapharm Gmbh, Betapharm Arzneimittel Gmbh, Denk Pharma Gmbh & Co. Kg, Juta Pharma Gmbh, Abz-Pharma Gmbh, Vivanta Generics S.R.O, Aliud Pharma Gmbh · 23 register entries
- ClopipurenPuren Pharma Gmbh & Co. Kg · 1 register entry
- PlavocorinHexal Ag · 1 register entry
- ZopyaTad Pharma Gmbh · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Turkey
- As-ClodipAPOTEX İLAÇ SAN VE TİC. LTD. ŞTİ. · 1 register entry
- AtervixBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- CardogrelSANDOZ İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- CloganDEVA HOLDİNG A.Ş. · 3 register entries
- CloperolHUMANİS SAĞLIK A.Ş. · 2 register entries
- ClopitroGENVEON İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- ClopraDROGSAN İLAÇLARI SAN. VE TİC. A.Ş. · 1 register entry
- DiloxolBİLİM İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- DiporelUMUT İLAÇ TİC. VE SAN. LTD. ŞTİ. · 1 register entry
- KarumSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- KlogelNEUTEC İLAÇ SAN. TİC. A.Ş · 2 register entries
- LopigrolWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
Show all 18 brand names
- OpirelALİ RAİF İLAÇ SAN. A.Ş. · 2 register entries
- PingelSANOFİ İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- PlanorKOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş. · 2 register entries
- PlavidolGRANDİ İLAÇ SAN. VE TİC. LTD. ŞTİ · 1 register entry
- PlavixSANOFİ SAĞLIK ÜRÜNLERİ LTD. ŞTİ. · 2 register entries
- PloveksLİVA İLAÇ PAZARLAMA SAN. VE TİC. A.Ş. · 2 register entries
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
Brand names in 27 more European countries
- Belgium
- Clopidogrel (Hcl) Sandoz, Clopidogrel Eg
- Bulgaria
- Глопенел, Калдера Spm, Клопидогрел ?????, Клопидогрел Акорд, Клопидогрел Екофарм, Клопинео, Плакекс, Тромбекс
- Croatia
- Gardin, Klopidex, Klopidogrel Pharmas, Kogrel
- Cyprus
- Adagrel, Clopidogrel Accord, Clovelen, Larvin
- Czechia
- Clopidogrel Accord, Clopidogrel Medreg, Clopidogrel Reddy, Clopidogrel Stada, Trombex
- Denmark
- Clopidogrel "juta", Clopidogrel Accord, Clopidogrel Actavis, Clopidogrel Amarox, Clopidogrel Juta, Clopidogrel Medical Valley, Clopidogrel Orion, Clopidogrel Pharmathen, Clopidogrel Stada, Clopimar, Cloriocard, Maddogrel, Vatoud
- Estonia
- Clopidogrel Sanoswiss, Trombex
- Finland
- Clopidogrel
- France
- Clopidogrel Accord, Clopidogrel Almus Pharma, Clopidogrel Alter, Clopidogrel Arrow, Clopidogrel Biogaran, Clopidogrel Cristers, Clopidogrel Eg Labo, Clopidogrel Evolugen, Clopidogrel Sandoz, Clopidogrel Zf
- Greece
- Blodegrel, Carder, Clocardio, Clodelib, Clopadel, Clopidogrel Kleva, Clopidogrel Velka, Clopidosyn, Clopigren, Cloplate, Cloroden, Clovelen, Clovix, Darxa, Dasogrel-S, Demogrel, Denovex, Diclop, Globel, Iscodil, Isroen, Larvin, Novigrel, Plasiver, Plavelate, Plavidosa, Sanvix, Throimper, Unplaque, Zakogrel
- Hungary
- Clopidogrel Demo, Kardogrel, Kerberan, Plagrel, Qydaxer, Trombex
- Iceland
- Clopidogrel Krka, Clopidogrel Medical Valley, Clopidogrel Tad, Clopidogrel Teva, Clopidogrel Viatris, Clopidogrel Zentiva, Iscover, Plavix, Zyllt
- Ireland
- Clodel, Clopidogrel Accord Healthcare, Clopidogrel Azure, Clopidogrel Clonmel, Clopidogrel Msn
- Italy
- Averelix, Clopidogrel Almus Pharma, Clopidogrel Alter, Clopidogrel Aurobindo, Clopidogrel Doc Generici, Clopidogrel Eg Stada, Clopidogrel Pensa, Clopidogrel Sandoz Gmbh, Clopidogrel Tecnigen, Clopidogrel Viatris Italia, Clopinovo, Nogreg
- Latvia
- Trombex
- Liechtenstein
- Clopidogrel Ratiopharm, Clopidogrel Viatris, Clopidogrel Zentiva, Iscover, Plavix
- Lithuania
- Clopidogrel Sanoswiss, Trombex
- Luxembourg
- Clopidogrel (Hcl) Sandoz, Clopidogrel Eg
- Malta
- Clopidogrel Aurobindo, Clopidogrel Azure
- Netherlands
- Clopidogrel (Als Hydrochloride) Sandoz, Clopidogrel Accord, Clopidogrel Amarox, Clopidogrel Cf, Clopidogrel Hydrogen Sulfate Aurobindo, Clopidogrel Reddy, Clopidogrel Vivanta, Clopidogrel Xiromed
- Norway
- Clopidogrel Accord, Clopidogrel Actavis, Clopidogrel Krka, Clopidogrel Medical Valley, Clopidogrel Tad, Clopidogrel Teva, Clopidogrel Viatris, Clopidogrel Zentiva, Iscover, Plavix, Zyllt
- Poland
- Areplex, Clopidogrel Bluefish, Clopidogrel Medreg, Clopidogrel Msn, Clopidogrel Ranbaxy, Pegorel, Plavocorin, Trombex, Vixam
- Portugal
- Clopidogrel Aba Farmoz - Sociedade Técnico Medicinal, Clopidogrel Adapes, Clopidogrel Almus Pharma, Clopidogrel Alter, Clopidogrel Atral, Clopidogrel Aurobindo, Clopidogrel Aurovitas, Clopidogrel Balplak, Clopidogrel Biofarmoz, Clopidogrel Bluepharma, Clopidogrel Bluesar, Clopidogrel Ciclum Farma, Clopidogrel Farmoz, Clopidogrel Generis Phar, Clopidogrel Gp, Clopidogrel Kaissan Sandoz, Clopidogrel Krival, Clopidogrel Labesfal, Clopidogrel N/A, Clopidogrel Pharmacare, Clopidogrel Pharmakern, Clopidogrel Premium Pharma, Clopidogrel Refta, Clopidogrel Sandoz, Clopidogrel Tecnigen, Clopidogrel Tecnilor, Clopidogrel Trafar, Nastilox, Pravidel, Trokilus
- Romania
- Clopidogrel Arena, Clopidogrel Eipico, Clopidogrel Gemax Pharma, Clopidogrel Msn, Clopidogrel Terapia, Trombex
- Slovakia
- Clopidogrel Medreg, Clopigamma, Plovtt, Trombex
- Spain
- Clopidogrel Almus, Clopidogrel Alter, Clopidogrel Aurovitas, Clopidogrel Cinfamed, Clopidogrel Codramol Farmalider, Clopidogrel Dermogen, Clopidogrel Esseti, Clopidogrel Farmalid, Clopidogrel Farmalider, Clopidogrel Kern Pharma, Clopidogrel Mabo, Clopidogrel Normon, Clopidogrel Opko, Clopidogrel Pensa, Clopidogrel Pharma Combix, Clopidogrel Qualigen, Clopidogrel Sandoz, Clopidogrel Stada, Clopidogrel Stadafarma, Clopidogrel Sun, Clopidogrel Tarbis, Clopidogrel Tecnigen, Clopidogrel Vir Pharma, Clopidogrel Viso Farmacéutica, Maboclop, Nastilox, Vatoud
- Sweden
- Clopidogrel Accord, Clopidogrel Actavis, Clopidogrel Aliud, Clopidogrel Amarox, Clopidogrel Medical Valley, Clopidogrel Orion, Clopidogrel Stada, Cloriocard
EMA – Article 57 product data (EU/EEA), 2026-10-28
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Sources
- European Medicines Agency. Clopidogrel Zentiva (previously Clopidogrel Winthrop) – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/clopidogrel-zentiva-epar-product-information_en.pdf
- European Medicines Agency. Iscover – EPAR, Product Information (OF THE TEXT <DD month YYYY> Detailed information on this med). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/iscover-epar-product-information_en.pdf
- European Medicines Agency. Plavix – EPAR, Product Information (OF THE TEXT <DD month YYYY> Detailed information on this med). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/plavix-epar-product-information_en.pdf
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- Wikidata (CC0): ATC B01AC.
Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error
Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.