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Bisoprolol

Bisocor, Bisoprolol, Bisostad, Concor · ATC code C07AB07

Also known as: Bisoprolol Fumarate · Brand names: Bisocor, Bisostad, Concor, Bisobeta, Bisogamma, Bisohexal, Bisolich, Conaret, Kardoritm, Kenoden, Rizoprol

Key facts
Active substance
Bisoprolol
Drug class
Beta blocker
ATC code
C07AB07
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Bisoprolol is a relatively beta-1-selective beta-blocker. According to the US label, it is indicated for the management of hypertension, alone or combined with other antihypertensive agents.

What it is used for

  • Management of hypertension
  • Alone or in combination with other antihypertensive agents

Dosing

  • Dose is individualized; usual starting dose 5 mg once daily
  • In some patients (e.g. bronchospastic disease) 2.5 mg may be an appropriate starting dose
  • If the effect is inadequate, increase to 10 mg and then, if necessary, to 20 mg once daily
  • Hepatic impairment or renal dysfunction (creatinine clearance less than 40 mL/min): initial dose 2.5 mg, cautious titration
  • Elderly: no adjustment unless significant renal or hepatic dysfunction
  • No pediatric experience

Contraindications

  • Cardiogenic shock
  • Overt cardiac failure
  • Second or third degree AV block
  • Marked sinus bradycardia

Important warnings

  • Cardiac failure: beta-blockade may depress contractility; consider discontinuation at first signs of heart failure
  • Abrupt cessation may cause angina exacerbation, myocardial infarction or ventricular arrhythmia in coronary artery disease; taper over about one week
  • Bronchospastic disease: use only with caution at the lowest dose; keep a beta-2 agonist available
  • May mask signs of hypoglycemia (especially tachycardia) and of hyperthyroidism
  • Peripheral vascular disease: may precipitate or aggravate arterial insufficiency
  • Major surgery: chronic therapy should not be routinely withdrawn; anesthesia risk may be increased

Side effects

  • Reported in trials: dizziness, fatigue/asthenia, arthralgia, increased sweating
  • Bradycardia, diarrhea, asthenia, fatigue and sinusitis appear dose related
  • Withdrawal for adverse events was lower than with placebo (3.3% vs 6.8%)

Interactions

  • Should not be combined with other beta-blockers
  • Catecholamine-depleting drugs (reserpine, guanethidine): monitor closely
  • Clonidine: when stopping, discontinue bisoprolol several days before clonidine
  • Verapamil, diltiazem, disopyramide and other AV-conduction inhibitors: use with care
  • Digitalis glycosides: increased risk of bradycardia
  • Rifampin increases clearance; initial dose modification generally not necessary

Pregnancy and breastfeeding

  • No adequate studies in pregnant women; use only if the potential benefit justifies the risk to the fetus
  • Unknown whether excreted in human milk; caution in nursing women

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • BisocorKwizda Pharma Gmbh · 1 register entry
  • Bisoprolol1a Pharma Gmbh, Teva B.V, Viatris Limited, Stada Arzneimittel Gmbh, Accord Healthcare B.V., Sandoz Gmbh, Drehm Pharma Gmbh, Krka, D.D., Novo Mesto · 8 register entries
  • BisostadStada Arzneimittel Gmbh · 1 register entry
  • ConcorMerck Gesellschaft Mbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • BisobetaBetapharm Arzneimittel Gmbh · 2 register entries
  • BisogammaAaa-Pharma Gmbh, Wörwag Pharma Gmbh & Co. Kg · 2 register entries
  • BisohexalHexal Ag · 1 register entry
  • BisolichZentiva Pharma Gmbh · 1 register entry
  • Bisoprolol1 A Pharma Gmbh, Ratiopharm Gmbh, Amarox Pharma Gmbh, Dexcel Pharma Gmbh, Viatris Germany Gmbh, Stadapharm Gmbh, Ipca Productos Farmaceuticos Unipessoal Lda, Abz-Pharma Gmbh, Tad Pharma Gmbh, Aliud Pharma Gmbh · 13 register entries
  • ConaretZentiva Pharma Gmbh · 1 register entry
  • ConcorMerck Healthcare Germany Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • ConcorDAİİCHİ SANKYO İLAÇ TİC. LTD. ŞTİ. · 2 register entries
  • KardoritmNOBEL İLAÇ PAZARLAMA VE SAN. LTD. ŞTİ. · 3 register entries
  • KenodenNOBEL İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • RizoprolWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 4 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 27 more European countries
Belgium
Bisoprolol Ab, Bisoprolol Eg, Bisoprolol Sandoz, Bisoprolol Teva, Bisoprolol Viatris, Bisoprololfumarat Eg
Bulgaria
Blokbis, Kardoritm, Бизогамма Bisogamma, Бизолен, Бизопролол Майлан, Бизор, Бизостад, Бизохексал, Блокбис, Кардоритъм, Конкор, Ризопрол, Собикор, Тирез
Croatia
Bisobel, Byol, Concor, Kordobis, Lybrol, Sobycor, Tyrez
Cyprus
Bisoprolol Sapiens, Concor, Emconcor
Czechia
Bisocard, Bisoprolol Medreg, Bisoprolol Pmcs, Bisoprolol Ratiopharm, Bisoprolol Viatris, Concor, Rivocor, Sobycor
Denmark
Bisoprolol Krka, Bisoprolol Medical Valley, Bisoprolol Sandoz, Bisoprolol Stada, Bisoprolol Teva, Bisoprolol Zentiva, Cardiospir, Cardovia
Estonia
Bisoprolol Accord, Bisoprolol Zentiva, Sobycor
Finland
Bisoproact, Bisoprolol Accord, Bisoprolol Krka, Bisoprolol Orion, Bisoprolol Ratiopharm, Bisoprolol Sandoz, Cardovia, Emconcor, Orloc
France
Bisoprolol Arrow Lab, Bisoprolol Biogaran, Bisoprolol Eg, Bisoprolol Evolugen, Bisoprolol Krka, Bisoprolol Quiver Lab, Bisoprolol Sandoz, Bisoprolol Teva, Bisoprolol Viatris Sante, Bisoprolol Zentiva, Bisoprolol Zydus France, Cardensiel, Detensiel
Greece
Concor, Emconcor, Theracor
Hungary
Bisoblock, Bisocard, Bisogamma, Bisoprolol Ratiopharm, Bisoprolol Sandoz, Concor, Coviogal, Dorez, Sobycor
Iceland
Bisoprolol Medical Valley, Cardovia
Ireland
Bisocor, Bisop, Bisoprolol Accord Healthcare Ireland, Bisoprolol Clonmel, Bisoprolol Fumarate Chanelle Medical, Bisoprolol Fumarate Pinewood Laboratories, Bisoprolol Fumarate Unichem Laboratories, Bisoprolol Krka, Bisoprolol Syri Pharma, Bisoprolol Viatris, Bisoprolol Zentiva, Cardicor
Italy
Bisoprololo Ahcl, Bisoprololo Almus, Bisoprololo Aurobindo Pharma Italia, Bisoprololo Doc Generics, Bisoprololo Eg, Bisoprololo Krka, Bisoprololo Mylan, Bisoprololo Pensa, Bisoprololo Sandoz, Bisoprololo Tecnigen, Bisoprololo Teva, Bisoprololo Zentiva Generics, Bisoprololo Zentiva Italia, Cardicor, Concor, Congescor, Sequacor
Latvia
Bisogamma, Bisoprolol Accord, Bisoprolol Ratiopharm, Bisoprolol Zentiva, Concor, Sobycor
Lithuania
Bisoprolol Fumarate Zentiva, Zonsiloc
Luxembourg
Bisoprolol Eg, Bisoprolol Sandoz, Concor
Malta
Bisoprolol Ipca
Netherlands
Bisoprolol Fumaraat Pch, Bisoprolol Fumaraat Teva, Bisoprolol Fumarate Aurobindo, Bisoprolol Syri Pharma, Bisoprololfumaraat, Byblok, Emcor Deco
Norway
Bisoprolol Sandoz, Bisoprolol Zentiva, Cardovia, Emconcor
Poland
Bibloc, Bicardef, Bisocard, Bisohexal, Bisoprolol Aurovitas, Bisoprolol Vp, Bisopromerck, Bisoratio, Blocard, Borez, Conaret, Concor, Corectin, Coronal, Corsib, Sobycor
Portugal
Bisoprolol, Concor
Romania
Bisogamma, Bisoprolol Gemax Pharma, Bisotens, Borez, Concor, Sobyc
Slovakia
Bisocard, Bisomerck, Bisoprolol Medreg, Bisoprolol Ratiopharm, Conaret, Concor, Coronal, Rivocor, Sobycor, Tyrez
Slovenia
Borez, Byol, Concor, Sobycor
Spain
Bisoprolol Aurovitas, Bisoprolol Cinfa, Bisoprolol Combix, Bisoprolol Cor Alter, Bisoprolol Fumarato Uxa Farma S.A., Bisoprolol Kern Pharma, Bisoprolol Krka, Bisoprolol Mylan Pharmaceuticals, Bisoprolol Normon, Bisoprolol Pensa, Bisoprolol Sandoz, Bisoprolol Stada, Bisoprolol Stadafarma, Bisoprolol Tarbis Farma, Bisoprolol Tecnigen, Bisoprolol Teva, Bisoprolol Viatris, Bisoprolol Zentiva, Emconcor
Sweden
Bisomyl Viatris, Bisoprolol Accord, Bisoprolol Bausch Health, Bisoprolol Farmacia, Bisoprolol Krka, Bisoprolol Medical Valley, Bisoprolol Merck, Bisoprolol Ratiopharm, Bisoprolol Sandoz, Bisoprolol Stada, Bisoprolol Teva, Bisoprolol Zentiva, Bisostad, Cardicor, Cardovia, Emconcor, Libracor

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. U.S. Food and Drug Administration. Bisoprolol Fumarate (Rising Pharma Holdings, Inc.) – Prescribing Information, 2025-05-16. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=200ab93b-6ad3-46cb-8f57-db056a14de16
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC C07AB.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.