tigecycline
Tygacil · ATC code J01AA12
Also known as: Tigecyclin · Brand names: Tygacil, Tigecyclin Aptapharma, Tigecyclin Hikma, Tigecyclin Lyomark, Tigecyclin Viatris, Tigecyclin Amarox, Tigecyclin Carinopharm, Tigecyclin Cipla, Tigecyclin Mylan, Tigecyclin Panpharma, Tigecyclin Piramal, Tigecyclin Ratiopharm, Tigecycline Noridem, Mrsacin, Pitazin …
- Key facts
- Active substance
- tigecycline
- Drug class
- Tetracycline
- ATC code
- J01AA12
- Authorisation
- centrally authorised across the EU (EMA)
- Dosage forms
- Tygacil 50 mg powder for solution for infusion
- Marketing authorisation holder
- Pfizer Europe MA EEIG
- Information as of
- 2026-10-27
Key facts
Tigecycline is a glycylcycline antibiotic related to the tetracyclines. It is given intravenously for complicated skin and soft tissue infections and complicated intra-abdominal infections.
What it is used for
- Complicated skin and soft tissue infections (excluding diabetic foot infections) in adults and children from eight years
- Complicated intra-abdominal infections
- Only when other antibiotics are not suitable
Dosing
- Adults: initial dose 100 mg, then 50 mg every 12 hours for 5 to 14 days
- Children 8 to <12 years: 1.2 mg/kg every 12 hours (maximum 50 mg every 12 hours)
- Adolescents 12 to <18 years: 50 mg every 12 hours
- Severe hepatic impairment (Child Pugh C): reduce dose by 50%; adults 25 mg every 12 hours after the 100 mg loading dose
- No adjustment in renal impairment or the elderly; infuse over 30 to 60 minutes
Contraindications
- Hypersensitivity to the active substance or any excipient
- Patients hypersensitive to tetracyclines may be hypersensitive to tigecycline
Important warnings
- Numerically higher mortality than comparators in clinical studies
- Superinfection, especially nosocomial pneumonia; watch for impaired wound healing
- Anaphylaxis, hepatic failure, acute pancreatitis
- Prolonged PT/aPTT, hypofibrinogenaemia; tooth discolouration – not for children under 8 years
Side effects
- Very common: nausea (21%), vomiting (13%), usually early and mild to moderate; diarrhoea
- Common: abdominal pain, dyspepsia, anorexia, dizziness, phlebitis, sepsis, pneumonia, abscess
- Prolonged coagulation times, hypoglycaemia, hypoproteinaemia
Interactions
- Warfarin: reduced clearance; monitor coagulation tests closely with anticoagulants
Pregnancy and breastfeeding
- Use only if the clinical condition requires it; possible permanent dental defects and delayed ossification in the foetus
Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
Common questions – ask Medelix
For patients
Package leaflet, verbatim
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
EU – centrally authorised (all member states)
- Tigecycline Accord · genericAccord Healthcare S.L.U. · EMEA/H/C/005114
- TygacilPfizer Europe MA EEIG · EMEA/H/C/000644
Source: European Medicines Agency (EMA), product information
Austria
- Tigecyclin AptapharmaApta Medica Internacional D.O.O. · 1 register entry
- Tigecyclin HikmaHikma Farmacêutica (Portugal), S.A. · 1 register entry
- Tigecyclin LyomarkBendalis Gmbh · 1 register entry
- Tigecyclin ViatrisViatris Limited · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Germany
- Tigecyclin AmaroxAmarox Pharma Gmbh · 1 register entry
- Tigecyclin CarinopharmCarinopharm Gmbh · 1 register entry
- Tigecyclin CiplaCipla Europe Nv · 1 register entry
- Tigecyclin HikmaHikma Farmacêutica (Portugal), S.A. · 1 register entry
- Tigecyclin LyomarkBendalis Gmbh · 1 register entry
- Tigecyclin MylanViatris Germany Gmbh · 1 register entry
- Tigecyclin PanpharmaPanmedica · 1 register entry
- Tigecyclin PiramalPiramal Critical Care B.V. · 1 register entry
- Tigecyclin RatiopharmRatiopharm Gmbh · 1 register entry
- Tigecycline NoridemNoridem Enterprises Ltd · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Turkey
- MrsacinBİEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- PitazinGENVEON İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- TgixelDEVA HOLDİNG A.Ş. · 1 register entry
- TigecidCENTURİON İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- TigejectTÜM-EKİP İLAÇ A.Ş. · 1 register entry
- TigenexHAVER TRAKYA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- Tigesil-LiyoKOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş. · 1 register entry
- TybicidINCPHARMA İLAÇ SAN. VE TİC. LTD. ŞTİ. · 1 register entry
- TygacilPFİZER PFE İLAÇLARI A.Ş. · 1 register entry
- TygepolPOLİFARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- TygexVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
Brand names in 26 more European countries
- Bulgaria
- Тигециклин Аптафарма, Тигециклин Ромфарм
- Croatia
- Tigeciklin Aptapharma, Tigeciklin Galenika
- Cyprus
- Tigecycline Aptapharma, Tigecycline Sapiens
- Czechia
- Tigecycline Aptapharma, Tigecycline Mylan, Tigecycline Noridem, Tigecycline Olikla, Tigecyklin Galenika
- Denmark
- Tigecycline Eql Pharma
- Estonia
- Tigecycline Inteli, Tigecycline Norameda
- Finland
- Tigecycline Eql Pharma, Tigecycline Norameda
- France
- Tigecycline Amarox, Tigecycline Hikma, Tigecycline Viatris
- Greece
- Digazor, Tigecycline Anfarm, Tigecycline Cooper, Tigecycline Demo
- Hungary
- Tigeciklin Galenika, Tigeciklin Noridem, Tigecycline Anfarm, Tigecycline Aptapharma, Tigecycline Teva
- Iceland
- Tigecycline Accord, Tygacil
- Ireland
- Tigecycline Noridem Enterprises
- Italy
- Tigeciclina Amarox, Tigeciclina Cipla, Tigeciclina Hikma, Tigeciclina Mylan Pharma, Tigeciclina Tecnigen, Tigeciclina Teva, Tigecycline Noridem
- Latvia
- Tigecycline Inteli, Tigecycline Norameda
- Liechtenstein
- Tigecycline Accord, Tygacil
- Lithuania
- Tigecycline Inteli, Tigecycline Norameda
- Malta
- Tigecycline Anfarm, Tigecycline Aptapharma, Tigecycline Atb, Tigecycline Diagonalis, Tigecycline Galenicum, Tigecycline Hikma
- Netherlands
- Tigecycline Amarox, Tigecycline Hikma
- Norway
- Tigecycline Accord, Tigecycline Eql Pharma, Tygacil
- Poland
- Tigecycline Aptapharma, Tigecycline Norameda, Tigecycline Noridem, Tigecycline Pharmline, Tigecycline Tzf, Tigecycline Viatris
- Portugal
- Tigeciclina Cipla, Tigeciclina Hikma, Tigeciclina Mylan, Tigeciclina Tecnigen
- Romania
- Tigeciclina Atb, Tigeciclina Rompharm, Tigeciclină Aptapharma, Tigeciclină Noridem, Tigeciclină Viatris
- Slovakia
- Tigecycline Aptapharma, Tigecycline Noridem, Tigecyklin Galenika
- Slovenia
- Tigeciklin Aptapharma, Tigeciklin Diagonalis, Tigeciklin Galenika
- Spain
- Tigeciclina Cipla, Tigeciclina Hikma, Tigeciclina Normon, Tigeciclina Tarbis, Tigeciclina Tecnigen, Tigeciclina Viatris, Tigecycline Noridem
- Sweden
- Tigecycline Eql Pharma, Tigecycline Viatris, Tigecyklin Amarox
EMA – Article 57 product data (EU/EEA), 2026-10-28
Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.
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Sources
- European Medicines Agency. Tygacil – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/tygacil-epar-product-information_en.pdf
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- Wikidata (CC0): ATC J01AA.
Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error
Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.