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Doxycycline

Doxybene, Doxycyclin G.L, Doxycyclin G.L., Doxycyclin Genericon · ATC code J01AA02

Also known as: Doxycyclin, Doksisiklin, Doxycycline Hyclate · Brand names: Doxybene, Doxycyclin G.L, Doxycyclin G.L., Doxycyclin Genericon, Doxycyclin Macure, Doxyderm, Doxydyn, Ligosan, Oraycea, Vibramycin, Doxakne Tabs, Doxy, Doxycycline Sf Ratiopharm, Doxycyclinhyclat Al, Doxyderma …

Key facts
Active substance
Doxycycline
Drug class
Tetracycline
ATC code
J01AA02
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Doxycycline is a tetracycline-class antibiotic. This US label (capsules) lists many bacterial infections, including rickettsial, chlamydial and mycoplasma infections, as well as malaria prophylaxis.

What it is used for

  • Rickettsial infections (e.g. Rocky Mountain spotted fever, typhus fever, Q fever)
  • Respiratory tract infections caused by Mycoplasma pneumoniae; psittacosis
  • Chlamydia trachomatis infections (incl. uncomplicated urethral, endocervical or rectal infections, trachoma, inclusion conjunctivitis)
  • Other infections caused by susceptible bacteria, post-exposure anthrax; alternative when penicillin is contraindicated (e.g. syphilis)
  • Prophylaxis of malaria in short-term travelers

Dosing

  • Adults: 200 mg on the first day (100 mg every 12 hours), then 100 mg/day; for more severe infections 100 mg every 12 hours
  • Children under 45 kg with severe or life-threatening infections: 2.2 mg/kg every 12 hours; 45 kg or more receive the adult dose
  • Children over 8 years under 45 kg with less severe disease: 4.4 mg/kg on the first day, then 2.2 mg/kg daily
  • Chlamydial infection or nongonococcal urethritis: 100 mg twice a day for 7 days
  • Malaria prophylaxis: adults 100 mg daily, starting 1 to 2 days before travel and continuing for 4 weeks after leaving the area
  • Take with adequate fluid; no accumulation in renal impairment; further regimens in the full text

Contraindications

  • Hypersensitivity to any of the tetracyclines

Important warnings

  • Use during tooth development (last half of pregnancy, childhood to age 8) may cause permanent tooth discoloration; in children only for severe or life-threatening conditions
  • Clostridioides difficile-associated diarrhea, ranging up to fatal colitis
  • Photosensitivity: discontinue at the first evidence of skin erythema
  • Intracranial hypertension (pseudotumor cerebri) with headache and visual disturbances
  • Overgrowth of nonsusceptible organisms, including fungi

Side effects

  • Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia; rare esophagitis and esophageal ulceration
  • Skin: rashes, photosensitivity; serious reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome
  • Hepatotoxicity reported rarely; dose-related rise in BUN

Interactions

  • Anticoagulants: downward adjustment of anticoagulant dosage may be required
  • Antacids containing aluminum, calcium or magnesium, iron preparations and bismuth subsalicylate impair absorption
  • Barbiturates, carbamazepine, phenytoin and rifampin shorten the half-life
  • Avoid combining with penicillin

Pregnancy and breastfeeding

  • Pregnancy: no adequate studies; use in the last half of pregnancy can cause tooth discoloration
  • Nursing: tetracyclines are excreted in human milk; decide whether to discontinue nursing or the drug

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • DoxybeneTeva B.V · 2 register entries
  • Doxycyclin G.LG.L. Pharma Gmbh · 1 register entry
  • Doxycyclin G.L.G.L. Pharma Gmbh · 1 register entry
  • Doxycyclin GenericonGenericon Pharma Gesellschaft M.B.H. · 1 register entry
  • Doxycyclin MacureMacure Healthcare Limited · 1 register entry
  • DoxydermGlenwood Gmbh · 1 register entry
  • DoxydynGlenwood Gmbh · 1 register entry
  • LigosanKulzer Gmbh · 1 register entry
  • OrayceaGalderma International · 1 register entry
  • VibramycinPfizer Corporation Austria Ges.M.B.H. · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Doxakne TabsGalenpharma Gmbh · 1 register entry
  • DoxyDenk Pharma Gmbh & Co. Kg, Ratiopharm Gmbh · 2 register entries
  • Doxycyclin1 A Pharma Gmbh, Aliud Pharma Gmbh, Stadapharm Gmbh, Denk Pharma Gmbh & Co. Kg · 5 register entries
  • Doxycycline Sf RatiopharmRatiopharm Gmbh · 1 register entry
  • Doxycyclinhyclat AlAliud Pharma Gmbh · 1 register entry
  • DoxydermaDermapharm Ag · 1 register entry
  • Doxyhexal TabsHexal Ag · 1 register entry
  • LigosanKulzer Gmbh · 2 register entries
  • OrayceaGalderma Laboratorium Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • EtidoksNOBEL İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • MonodoksDEVA HOLDİNG A.Ş. · 1 register entry
  • RosergolWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • TetradoxTEVA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • Acticlate CAPAqua Pharmaceuticals · 1 register entry
  • Doxycyclate Hyclate1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 28 more European countries
Belgium
Doxycycline Eg, Doxycycline Sandoz, Doxynord, Efracea, Vibratab
Bulgaria
Вибрамицин, Доксициклин Tzf, Доксициклин Абр, Доксициклин Актавис, Доксициклин Стада
Croatia
Doksiciklin Belupo
Cyprus
Doxat, Medomycin, Remycin, Vibramycin
Czechia
Deoxymykoin, Doxybene, Doxyhexal
Denmark
Doxycycline Macure, Oracea, Vibradox
Estonia
Adoxtar, Doxy-M, Doxycyclin Stada, Doxycycline Vitabalans, Doxylan
Finland
Doximed, Doximycin, Doxitin, Doxycycline Macure, Oracea
France
Doxy, Doxycycline Arrow, Doxycycline Biogaran, Doxycycline Pharmacie Centrale Des Armees, Doxycycline Sandoz, Doxycycline Viatris, Doxypalu, Efracea, Tolexine, Vibraveineuse
Greece
Oracea, Smilitene, Vibramycin
Hungary
Doxitidin, Doxycyclin Al, Doxycyclin Pannonpharma, Doxypharm, Doxyprotect, Tenutan
Iceland
Doxycyklin Eql Pharma, Oracea
Ireland
Doxycycline Activase Pharmaceuticals, Doxycycline Athlone Pharmaceuticals, Doxycycline Bluefish, Doxycycline Pinewood, Doxycycline Teva, Efracea, Vibramycin
Italy
Bassado, Doxynor, Efracea, Farmodoxi, Ligosan, Miraclin
Latvia
Doxitin, Doxy-M, Doxycyclin Stada, Doxylan, Tardox
Liechtenstein
Ligosan
Lithuania
Adoxtar, Doxitin, Doxy-M, Doxycyclin Stada, Doxycyclin Tc
Luxembourg
Doxycycline Eg, Doxycycline Sf Ratiopharm, Efracea, Vibratab
Malta
Doxat, Doxycycline Activase, Medomycin, Remycin, Tolexine
Netherlands
Doxycycline Disp Teva, Doxycycline Dispers Prolepha, Doxycycline Dispers Ria, Doxycycline Macure, Doxycycline Monohydrate Aurobindo, Efracea
Norway
Doksycyklin Hexal, Doxycycline Macure, Doxylin, Oracea
Poland
Doxyclinum Tzf, Doxycycline, Doxycyclinum Polfarmex, Doxycyclinum Tzf, Efracea, Ligosan, Unidox Solutab
Portugal
Actidox, Adoxtar, Doxytrex, Efracea, Vibramicina
Romania
Doxiciclina Atb, Doxiciclină Arena
Slovakia
Deoxymykoin, Doxyhexal
Slovenia
Doksivibra
Spain
Dosil, Doxiciclina Normon, Doxiclat, Oracea, Proderma, Rexilen, Vibracina
Sweden
Doxycycline Macure, Doxycyklin Eql Pharma, Doxyferm, Oracea

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Doxycycline Hyclate (Hikma Pharmaceuticals USA Inc.) – Prescribing Information, 2025-10-28. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4ec4c8ca-ce83-4948-8626-21eb82ae5c19
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC J01AA.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.