Levofloxacin
Levofloxacin, Oftaquix · ATC code J01MA12
Also known as: Levofloksasin · Brand names: Oftaquix, Levoflox, Tavanic, Acomet, Beraxin, Floxilevo, Ilflox, Infecur, Kinoflox, Lebel, Lefosin, Lefox, Levadidoz, Levocur, Levoject …
- Key facts
- Active substance
- Levofloxacin
- Drug class
- Fluoroquinolone
- ATC code
- J01MA12
- Authorisation
- authorised nationally; no central EU authorisation
- Information as of
- 2026-10-27
Boxed warning
See full prescribing information for complete boxed warning.
- Fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together [see Warnings and Precautions (5.1)] , including: Tendinitis and tendon rupture [see Warnings and Precautions (5.2)] Peripheral neuropathy [see Warnings and Precautions (5.3)] Central nervous system effects[see Warnings and Precautions (5.4)]
Discontinue levofloxacin immediately and avoid the use of fluoroquinolones, including levofloxacin, in patients who experience any of these serious adverse reactions [see Warnings and Precautions (5.1)]
- Fluoroquinolones, including levofloxacin, may exacerbate muscle weakness in patients with myasthenia gravis. Avoid levofloxacin in patients with a known history of myasthenia gravis [see Warnings and Precautions (5.5)].
- Because fluoroquinolones, including levofloxacin, have been associated with serious adverse reactions [see Warnings and Precautions (5.1 to 5.15)] , reserve levofloxacin for use in patients who have no alternative treatment options for the following indications: Uncomplicated urinary tract infection [see Indications and Usage (1.12)] Acute bacterial exacerbation of chronic bronchitis [see Indications and Usage (1.13)] Acute bacterial sinusitis[see Indications and Usage (1.14)]
Key facts
Levofloxacin is a fluoroquinolone antibacterial. Per the US label it treats various bacterial infections in adults, including pneumonia, skin, urinary tract and prostate infections, and is used after anthrax or plague exposure.
What it is used for
- Nosocomial and community-acquired pneumonia
- Complicated and uncomplicated skin and skin structure infections; chronic bacterial prostatitis
- Complicated urinary tract infections and acute pyelonephritis
- Inhalational anthrax (post-exposure) and plague, including pediatric patients
- Uncomplicated UTI, acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis only when no alternative treatment options exist
Dosing
- Usual dose 250 mg, 500 mg or 750 mg every 24 hours depending on the infection
- Examples: nosocomial pneumonia 750 mg for 7 to 14 days; uncomplicated UTI 250 mg for 3 days; chronic bacterial prostatitis 500 mg for 28 days
- Creatinine clearance less than 50 mL/min: dosage regimen adjustment required (table in the full text)
- Pediatric patients (anthrax, plague): weight-based dosing in the full text
- Take antacids, sucralfate, iron or zinc multivitamins at least two hours before or after the dose
Contraindications
- Known hypersensitivity to levofloxacin or other quinolones
Important warnings
- Boxed warning: disabling and potentially irreversible reactions (tendinitis, tendon rupture, peripheral neuropathy, CNS effects); discontinue immediately
- Boxed warning: may exacerbate muscle weakness in myasthenia gravis; avoid with a known history
- Hypersensitivity reactions, hepatotoxicity, aortic aneurysm and dissection
- QT prolongation, blood glucose disturbances, photosensitivity, Clostridium difficile-associated diarrhea
- Increased musculoskeletal events in pediatric patients
Side effects
- Most common: nausea, headache, diarrhea, insomnia, constipation and dizziness
- Serious: tendon rupture, peripheral neuropathy, CNS reactions, hepatotoxicity, aortic dissection
Interactions
- Magnesium- or aluminum-containing antacids, sucralfate, iron, zinc, didanosine: reduced absorption
- Warfarin: enhanced effect with bleeding reported; monitor INR
- Antidiabetic agents: hypo- and hyperglycemia; NSAIDs: increased risk of CNS stimulation and seizures
Pregnancy and breastfeeding
- Published data have not identified a drug-associated risk of major birth defects or miscarriage
- Present in human milk; breastfeeding not recommended during treatment and for an additional two days (or pump and discard)
Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
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For patients
Patient information (US)
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
Austria
- Levofloxacin1a Pharma Gmbh, Apta Medica Internacional D.O.O., Actavis Group Ptc Ehf., Noridem Enterprises Ltd, Sandoz Gmbh, Vioser S.A., Hikma Farmacêutica (Portugal), S.A., Fresenius Kabi Austria Gmbh, Krka, D.D., Novo Mesto · 10 register entries
- OftaquixSanten Oy · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Germany
- LevofloxDenk Pharma Gmbh & Co. Kg · 1 register entry
- Levofloxacin1 A Pharma Gmbh, Dr. Friedrich Eberth Arzneimittel Gmbh, Noridem Enterprises Ltd, Infomed Fluids Srl, Ratiopharm Gmbh, Puren Pharma Gmbh & Co. Kg, Hec Pharm Gmbh, Heumann Pharma Gmbh & Co. Generica Kg, Ibigen Srl, Hameln Pharma Gmbh, Hexal Ag, Hikma Farmacêutica (Portugal), S.A., Stadapharm Gmbh, Denk Pharma Gmbh & Co. Kg, Fresenius Kabi Deutschland Gmbh, Aliud Pharma Gmbh · 17 register entries
- OftaquixSanten Oy · 2 register entries
- TavanicSanofi-Aventis Deutschland Gmbh · 2 register entries
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Turkey
- AcometMENTA PHARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- BeraxinBERKO İLAÇ VE KİMYA SAN. A.Ş. · 2 register entries
- FloxilevoDEVA HOLDİNG A.Ş. · 3 register entries
- IlfloxİLKO İLAÇ SAN.VE TİC. A.Ş. · 3 register entries
- InfecurNUVOMED İLAÇ SAN.TİC. A.Ş. · 5 register entries
- KinofloxRECORDATİ İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LebelNOBEL İLAÇ SAN. VE TİC. A.Ş. · 5 register entries
- LefosinMÜNİR ŞAHİN İLAÇ SAN. VE TİC A.Ş. · 1 register entry
- LefoxVEM İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- LevadidozGMG GRAND MEDİCAL İLAÇLARI LTD. ŞTİ. · 1 register entry
- LevocurCELTİS İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- LevofloxDEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
Show all 34 brand names
- LevojectTÜM-EKİP İLAÇ A.Ş. · 1 register entry
- LevolonBİLİM İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- LevonatATABAY KİMYA SAN. VE TİC. A.Ş. · 2 register entries
- LevonidinRECORDATİ İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- LevoworldWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LevoximedPHARMAPLACE İLAÇ TİC. A.Ş. · 2 register entries
- LevoxinHAVER TRAKYA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LevoxipolinPOLİFARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LevoxiworldWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LevozerKENTFARMA İLAÇ A.Ş. · 2 register entries
- LexsanTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş. · 2 register entries
- LexurHELBA İLAÇ İÇ VE DIŞ SAN. TİC. A.Ş. · 2 register entries
- LievoGENVEON İLAÇ SAN. VE TİC. A.Ş., YENİ İSVİÇRE SAĞLIK HİZMETLERİ İPEK İLAÇ ECZA DEPOSU SAN. VE TİC. LTD. ŞTİ. · 4 register entries
- LorenATAYURT İLAÇ SAN. İÇ VE DIŞ TİC. LTD. ŞTİ. · 2 register entries
- Multiflex LevoflexHAVER FARMA İLAÇ A.Ş. · 1 register entry
- NevotekBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 4 register entries
- PisanASET İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- PotantSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 5 register entries
- QufonsRDC İLAÇ ARAŞTIRMA VE GELİŞTİRME SAN. A.Ş. · 2 register entries
- RavivoDROGSAN İLAÇLARI SAN. VE TİC. A.Ş. · 3 register entries
- TavanicSANOFİ SAĞLIK ÜRÜNLERİ LTD. ŞTİ. · 2 register entries
- VoleflokKOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş. · 4 register entries
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
Brand names in 28 more European countries
- Belgium
- Levofloxacin Noridem, Levofloxacine Eg, Levofloxacine Fresenius Kabi, Levofloxacine Sandoz, Levofloxacine Viatris, Tavanic
- Bulgaria
- Levofloxacin Kabi, Levor, Адифлокс, Вивекс, Левалокс, Левокса, Левоксимед, Левор, Левотекс, Левофлоксан, Левофлоксацин Аптафарма, Левофлоксацин Екофарм, Левофлоксацин Зентива, Лефлокс, Неофлоксацин Мс Фарма Ад, Офтакуикс, Таваник, Фoвeлид, Флексид
- Croatia
- Flexid, Fovelid, Levalox, Levofloksacin Aptapharma, Levofloksacin Sandoz
- Cyprus
- Amesol, Fairlim, Floxasynt, Floxaval, Levofloxacin Aptapharma, Levofloxacin Noridem, Levofloxacin Vioser, Levofloxacin/Rafarm (Pf), Levonic, Levoxa, Levoxacin, Lexacin, Lexavon, Tavanic
- Czechia
- Levofloxacin Aptapharma, Levofloxacin Kabi, Levofloxacin Olikla, Levofloxacin Viatris, Oftaquix
- Denmark
- Levofloxacin Macure, Levofloxacin Noridem, Levonicopto, Oftaquix
- Estonia
- Levnibiot, Levofloxacin Basi, Levofloxacin Unimed Pharma, Oftaquix, Tavanic
- Finland
- Levofloxacin Fresenius Kabi, Levofloxacin Krka, Levofloxacin Noridem Enterprises, Levofloxacin Orion, Levonic, Oftaquix, Tavanic
- France
- Levofloxacine Accord Healthcare, Levofloxacine Almus, Levofloxacine Arrow, Levofloxacine Biogaran, Levofloxacine Cristers, Levofloxacine Eg, Levofloxacine Evolugen, Levofloxacine Kabi, Levofloxacine Krka, Levofloxacine La Colina, Levofloxacine Noridem, Levofloxacine Sandoz, Levofloxacine Teva, Levofloxacine Viatris, Levofloxacine Zentiva, Levofloxacine Zydus, Tavanic
- Greece
- Cinlevo, Evoxil, Flaxidel, Floxitard, Le-Vof, Levofloxacin Cooper, Levofloxacin Vioser, Levofloxacin Φαρματεν, Levofloxacin/Rafarm [pf], Levonic-Opto, Levoprolin, Lexacin, Lexavon, Talerin, Tavanic, Vlofinox, Zoclix
- Hungary
- Avatac, Leflokin, Lefloxawill, Levnibiot, Levofloxacin Aptapharma, Levofloxacin Kabi, Levofloxacin Reiwa Healthcare, Levofloxacin Sandoz, Levofloxacin Unimed Pharma, Levoxa, Oftaquix, Prixoter
- Iceland
- Oftaquix, Quinsair
- Ireland
- Levofloxacin, Tavager, Tavanic
- Italy
- Agilev, Allgram, Alvand, Aranda, Batiflox, Doclevo, Epifloxin, Falev, Findatur, Floxana, Floxistill, Floxsine, Gray, Kinofta, Klektica, Lemaxil, Levobat, Levodrop, Levofloxacina Abc, Levofloxacina Accord, Levofloxacina Almus, Levofloxacina Alter, Levofloxacina Aurobindo, Levofloxacina Bioindustria L.I.M., Levofloxacina Doc, Levofloxacina Eg, Levofloxacina Galenica Senese, Levofloxacina Kabi, Levofloxacina Krka, Levofloxacina Mylan Generics Italia, Levofloxacina Noridem, Levofloxacina Pensa Pharma, Levofloxacina Sandoz, Levofloxacina Tecnigen Italia, Levofloxacina Teva, Levofloxacina Zentiva, Levoxigram, Oftaquix, Petas, Sineflox, Socin, Summaflox, Tavanic, Trissil, Visuflox
- Latvia
- Levalox, Levofloxacin Basi, Levofloxacin Unimed Pharma, Oftaquix
- Liechtenstein
- Quinsair
- Lithuania
- Levalox, Levofloxacin Actavis, Levofloxacin Basi, Levofloxacin Unimed Pharma, Oftaquix
- Luxembourg
- Levofloxacine Eg, Levofloxacine Fresenius Kabi, Tavanic
- Malta
- Evoxil, Floxaval, Levofloxacin, Oftaquix
- Netherlands
- Levofloxacin Hemihydrate Aurobindo, Levofloxacine Beximco, Levofloxacine Fresenius Kabi, Levofloxacine Hikma, Levofloxacine Jubilant, Levofloxacine Noridem Enterprises, Levofloxacine Pch, Levofloxacine Sandoz, Levofloxacine Stada, Levofloxacine Zonder Conserveermiddel Rafarm, Levolige, Levonic, Maddoflox
- Norway
- Levofloxacin Macure, Levofloxacin Noridem Enterprises, Levonic, Quinsair
- Poland
- Levalox, Levocin, Levofloxacin Aptapharma, Levofloxacin Aurovitas, Levofloxacin Beximco, Levofloxacin Genoptim, Levofloxacin Kabi, Levofloxacin Noridem, Levofloxacin Sandoz, Levoftyal, Levomer, Levoxa, Oftaquix, Xyvelam, Zoftaro
- Portugal
- Lenovan, Levofloxacina, Levoftal, Oftaquix, Tavanic
- Romania
- Cenomar, Fleraday, Fovelid, L-Optic, Levalox, Levofloxacin Kabi, Levofloxacin Noridem, Levofloxacina Arena, Levofloxacina Teva, Levofloxacina Vioser, Levofloxacină Aptapharma, Levofloxacină Atb, Levofloxacină Infomed, Oftaquix, Tavanic, Tavoflox
- Slovakia
- Levalox, Levofloxacin Aptapharma, Levofloxacin Kabi, Levofloxacin Olikla, Oftaquix
- Slovenia
- Leviaben, Levofloksacin Aptapharma, Levofloksacin Kabi, Levofloksacin Lek, Levofloksacin Unimed Pharma, Tavanic
- Spain
- Bactyflox, Levofloxacin Sanovel, Levofloxacino Accord, Levofloxacino Almus, Levofloxacino Altan, Levofloxacino Alter, Levofloxacino Aurovitas, Levofloxacino Basi, Levofloxacino Cinfa, Levofloxacino Dermogen, Levofloxacino Farmalider, Levofloxacino Kabi, Levofloxacino Kern Pharma, Levofloxacino Krka, Levofloxacino Mabo-Farma, Levofloxacino Normon, Levofloxacino Pensa, Levofloxacino Pharma Combix, Levofloxacino Qualigen, Levofloxacino Reiwa Healthcare, Levofloxacino Sandoz, Levofloxacino Serraclinics, Levofloxacino Stada, Levofloxacino Sun, Levofloxacino Tarbis, Levofloxacino Tecnigen, Levofloxacino Teva, Levofloxacino Viatris, Levofloxacino Vir, Monoflox, Neumax, Tavanic
- Sweden
- Levofloxacin Actavis, Levofloxacin Krka, Levofloxacin Noridem, Levofloxacin Orion, Levofloxacin Viatris, Levonicopto, Oftaquix, Tavanic
EMA – Article 57 product data (EU/EEA), 2026-10-28
Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.
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Sources
- U.S. Food and Drug Administration. Levofloxacin (Lupin Pharmaceuticals, Inc.) – Prescribing Information, 2024-07-10. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4be13bd5-0c39-43c3-9232-b1226ccd4dbc
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- Wikidata (CC0): ATC J01MA.
Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error
Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.