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Levetiracetam

Keppra · ATC code N03AX14

Brand names: Keppra, Levebon, Tilamir, Anlev, Epi-No, Epilecure, Epilem, Epitam, Epixx, Ketiram, L-Cetam, Leptica, Lesitam, Lev-End, Levebrain …

Key facts
Active substance
Levetiracetam
Drug class
Anticonvulsant agent
ATC code
N03AX14
Authorisation
centrally authorised across the EU (EMA)
Dosage forms
Keppra 250 mg film-coated tablets · Keppra 500 mg film-coated tablets · Keppra 750 mg film-coated tablets · Keppra 1000 mg film-coated tablets · Keppra 100 mg/ml oral solution · Keppra 100 mg/ml concentrate for solution for infusion
Marketing authorisation holder
UCB Pharma SA
Information as of
2026-10-27

Key facts

Levetiracetam is an antiepileptic (pyrrolidone derivative) used as monotherapy or adjunctive therapy for several seizure types; available as tablets, oral solution and concentrate for infusion.

What it is used for

  • Monotherapy of partial onset seizures with or without secondary generalisation in newly diagnosed epilepsy from 16 years of age
  • Adjunctive therapy of partial onset seizures from 1 month of age (tablets/oral solution) or from 4 years (infusion)
  • Adjunctive therapy of myoclonic seizures in juvenile myoclonic epilepsy from 12 years
  • Adjunctive therapy of primary generalised tonic-clonic seizures in idiopathic generalised epilepsy from 12 years
  • Infusion: when oral administration is temporarily not feasible

Dosing

  • Adults and adolescents weighing 50 kg or more: initial dose 500 mg twice daily (or 250 mg twice daily for two weeks)
  • May be increased up to 1,500 mg twice daily, in 250 mg or 500 mg twice-daily steps every two to four weeks
  • Adolescents under 50 kg and children from 1 month: weight-based dosing (details in the full text)
  • Renal impairment: adjust to creatinine clearance; severe hepatic impairment: 50% reduction of maintenance dose when creatinine clearance is below 60 ml/min/1.73 m²
  • Withdraw gradually, e.g. adults over 50 kg: decrease by 500 mg twice daily every two to four weeks

Contraindications

  • Hypersensitivity to the active substance, other pyrrolidone derivatives or any excipient

Important warnings

  • Suicidal ideation and behaviour may occur; monitor for depression and suicidality
  • Psychotic symptoms and behavioural abnormalities such as irritability and aggressiveness
  • Rare decreases in blood cell counts; very rare acute kidney injury
  • Rare QT prolongation; caution with cardiac risk factors
  • Rare paradoxical worsening of seizures, mostly in the first month

Side effects

  • Most frequent: nasopharyngitis, somnolence, headache, fatigue and dizziness
  • Rare: pancytopenia, neutropenia, agranulocytosis, DRESS
  • Psychiatric reactions such as irritability, aggression, depression

Interactions

  • Does not influence levels of other antiepileptics
  • Methotrexate: reduced clearance with potentially toxic levels; monitor levels
  • Macrogol (osmotic laxative) should not be taken orally one hour before or after oral levetiracetam

Pregnancy and breastfeeding

  • Extensive monotherapy data do not suggest an increased risk of major malformations; avoid sudden discontinuation and review treatment when planning pregnancy
  • Excreted in human breast milk; breast-feeding is not recommended

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

Common questions – ask Medelix

For patients

Package leaflet, verbatim

Package leaflet for patients →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

EU – centrally authorised (all member states)

Source: European Medicines Agency (EMA), product information

Austria

  • LevebonG.L. Pharma Gmbh · 2 register entries
  • Levetiracetam1a Pharma Gmbh, Teva B.V, Genericon Pharma Gesellschaft M.B.H., +pharma Arzneimittel Gmbh, Kalceks, Noridem Enterprises Ltd, Accord Healthcare B.V., Sandoz Gmbh, Hikma Farmacêutica (Portugal), S.A., Stada Arzneimittel Gmbh, G.L. Pharma Gmbh, Fresenius Kabi Austria Gmbh, Krka, D.D., Novo Mesto, Ucb Pharma Gmbh · 18 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Levetiracetam1 A Pharma Gmbh, Betapharm Arzneimittel Gmbh, Neuraxpharm Arzneimittel Gmbh, Micro Labs Gmbh, Ratiopharm Gmbh, Puren Pharma Gmbh & Co. Kg, Altan Pharmaceuticals S.A., Glenmark Arzneimittel Gmbh, Hormosan Pharma Gmbh, Genmed Pharma Gmbh, Tillomed Pharma Gmbh, Winthrop Arzneimittel Gmbh, Axcount Generika Gmbh, Desitin Arzneimittel Gmbh, Heumann Pharma Gmbh & Co. Generica Kg, Holsten Pharma Gmbh, Noridem Enterprises Ltd, Abz-Pharma Gmbh, Stragen Pharma Gmbh, Troikaa Pharmaceuticals Europe S.R.O., Zentiva Pharma Gmbh, Amarox Pharma Gmbh, Ametas Medical Gmbh, Aristo Pharma Gmbh (Art 57), Basics Gmbh, Hexal Ag, Hikma Farmacêutica (Portugal), S.A., Stadapharm Gmbh, Aaa-Pharma Gmbh, Tad Pharma Gmbh, Ucb Pharma Gmbh, Aliud Pharma Gmbh · 47 register entries
  • TilamirStada Arzneimittel Ag · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • AnlevANGELİNİ İLAÇ SAN. VE TİC. A.Ş. · 5 register entries
  • Epi-NoAYTAÇ MUHİTTİN DİNÇER DİNÇTAŞ · 4 register entries
  • EpilecureTÜM-EKİP İLAÇ A.Ş. · 1 register entry
  • EpilemVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • EpitamALİ RAİF İLAÇ SAN. A.Ş. · 13 register entries
  • EpixxABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. · 18 register entries
  • KeppraUCB PHARMA A.Ş. · 6 register entries
  • KetiramTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş. · 1 register entry
  • L-CetamDEVA HOLDİNG A.Ş. · 14 register entries
  • LepticaİLKO İLAÇ SAN.VE TİC. A.Ş. · 4 register entries
  • LesitamHAVER TRAKYA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Lev-EndSANTA FARMA İLAÇ SAN. A.Ş. · 6 register entries
Show all 22 brand names
  • LevebrainWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 8 register entries
  • LevemaxNEUTEC İLAÇ SAN. TİC. A.Ş, VİTALİS İLAÇ SAN. TİC. A.Ş. · 15 register entries
  • LevenueMENTA PHARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • LevestoNOBEL İLAÇ PAZARLAMA VE SAN. LTD. ŞTİ. · 4 register entries
  • LevetamPOLİFARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • LevralNEUTEC İLAÇ SAN. TİC. A.Ş · 14 register entries
  • MolevVİTALİS İLAÇ SAN. TİC. A.Ş., CELTİS İLAÇ SAN. VE TİC. A.Ş. · 9 register entries
  • NetrolexSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 12 register entries
  • TirgenGENVEON İLAÇ SAN. VE TİC. A.Ş. · 26 register entries
  • VetriaBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 4 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 28 more European countries
Belgium
Larofec, Levetiracetam A.Forall, Levetiracetam Kabi, Levetiracetam Kalceks, Levetiracetam Noridem, Levetiracetam Sandoz
Bulgaria
Levebon, Леветиракон Pharmacons, Леветирацетам Стада, Ноепикс, Репитенд
Croatia
Levetiracetam Kalceks, Lyvam
Cyprus
Levetiracetam Noridem, Lyberen, Quetra
Czechia
Dretacen, Epiletam, Levelanz, Levetiracetam G.L. Pharma, Levetiracetam Kabi, Levetiracetam Kalceks, Levetiracetam Neuraxpharm, Levetiracetam Stada, Levetiracetam Ucb, Pterocyn, Trund
Denmark
Kevesy, Levetiracetam, Tilamir
Estonia
Levetiracetam Zentiva, Normeg
Finland
Larofec, Levetiracetam, Tilamir
France
Levetiracetam Accord, Levetiracetam Aguettant, Levetiracetam Arrow, Levetiracetam Biogaran, Levetiracetam Cristers, Levetiracetam Eg, Levetiracetam Evolugen, Levetiracetam Hikma, Levetiracetam Kalceks, Levetiracetam Krka, Levetiracetam Medipha Sante, Levetiracetam Noridem, Levetiracetam Sandoz, Levetiracetam Stragen, Levetiracetam Tillomed, Levetiracetam Viatris, Levetiracetam Zentiva, Levetiracetam Zydus, Levidcen
Greece
Ession, Kepricet, Letira, Levetiracetam Demo, Levetiracetam Kalceks, Levetiracetam Sandoz, Lyberen, Newlev
Hungary
Epiletam, Levetiracetam Kabi, Levetiracetam Kalceks, Levetiracetam Sandoz, Levetiracetam Stada, Levil
Iceland
Keppra, Levetiracetam Accord, Levetiracetam Actavis, Levetiracetam Hospira, Levetiracetam Ratiopharm, Levetiracetam Stada, Levetiracetam Sun, Levetiracetam Teva, Tilamir
Ireland
Larofec, Levetiracetam Brillpharma, Levetiracetam Clonmel, Levetiracetam Kalceks, Levetiracetam Noridem Enterprises, Levetiracetam Thame
Italy
Epitiram, Grifoxina, Italept, Levetiracetam Accord Healthcare, Levetiracetam Almus, Levetiracetam Alter, Levetiracetam Aristo Pharma, Levetiracetam Aurobindo, Levetiracetam Doc, Levetiracetam Docgen, Levetiracetam Eg, Levetiracetam Hikma, Levetiracetam Kalceks, Levetiracetam Krka, Levetiracetam Mylan, Levetiracetam Neuraxpharm, Levetiracetam Noridem, Levetiracetam Pensa, Levetiracetam Sandoz, Levetiracetam Tecnigen, Levetiracetam Teva, Levetiracetam Tillomed, Levetiracetam Troikaa, Levetiracetam Zentiva, Unipitiram
Latvia
Levetiracetam Kalceks
Liechtenstein
Keppra, Levetiracetam Accord, Levetiracetam Actavis, Levetiracetam Hospira, Levetiracetam Ratiopharm, Levetiracetam Teva
Lithuania
Dretacen, Levetiracetam Kalceks
Luxembourg
Larofec, Levetiracetam Micro Labs
Malta
Levetiracetam Accord, Levetiracetam Aurobindo, Levetiracetam Clonmel, Levetiracetam Ibigen, Levetiracetam Kabi, Quetra
Netherlands
Dretacen, Larofec, Levetiracetam, Trund
Norway
Keppra, Larofec, Levetiracetam, Tilamir
Poland
Cezarius, Lepsitam, Levebon, Levetiracetam Accord, Levetiracetam Aurovitas, Levetiracetam Kalceks, Levetiracetam Neuropharma, Levetiracetam Stada, Levetiracetamum Eugia, Normeg, Polkepral, Trund, Vetira
Portugal
Cinaz, Laurak, Levetiracetam A.Forall, Levetiracetam Accord, Levetiracetam Altan, Levetiracetam Alter, Levetiracetam Aristo, Levetiracetam Aurobindo, Levetiracetam Aurovitas, Levetiracetam Bluefish, Levetiracetam Bluepharma, Levetiracetam Ciclum, Levetiracetam Cinaz, Levetiracetam Farmoz, Levetiracetam Generis, Levetiracetam Hikma, Levetiracetam Jaba, Levetiracetam Kabi, Levetiracetam Kalceks, Levetiracetam Neogen, Levetiracetam Noridem, Levetiracetam Normon, Levetiracetam Pensa, Levetiracetam Sandoz, Levetiracetam Tecnigen, Levetiracetam Teva, Levetiracetam Tolife, Levetiracetam Troikaa, Levetiracetam Ucb, Levetiracetam Vitória, Levetiracetam Zentiva, Lovos, Pterocyn, Tirbas, Ziresta
Romania
Levetiracetam Accord, Levetiracetam Arena, Levetiracetam Aurobindo, Levetiracetam Desitin, Levetiracetam Terapia
Slovakia
Epiletam, Levetiracetam, Pterocyn, Trund
Slovenia
Levetiracetam Kalceks
Spain
Laurak, Levetiracetam Almus, Levetiracetam Altan, Levetiracetam Alter, Levetiracetam Aristo, Levetiracetam Aurovitas, Levetiracetam Cinfa, Levetiracetam Combix, Levetiracetam Desitin, Levetiracetam Farmalider, Levetiracetam Hikma, Levetiracetam Kalceks, Levetiracetam Kern Pharma, Levetiracetam Krka, Levetiracetam Liderfarm, Levetiracetam Mabo, Levetiracetam Noridem Enterprises Limited, Levetiracetam Normon, Levetiracetam Pensa, Levetiracetam Qualigen, Levetiracetam Sandoz, Levetiracetam Sanovel, Levetiracetam Stadafarma, Levetiracetam Stadagen, Levetiracetam Sun, Levetiracetam Tarbis, Levetiracetam Tecnigen, Levetiracetam Viatris, Levetiracetam Vir, Levetiracetam Zentiva, Tirbas
Sweden
Levebon, Levetiracetam, Tilamir

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. European Medicines Agency. Keppra – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/keppra-epar-product-information_en.pdf
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC N03AX.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.