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Trazodone

Trittico · ATC code N06AX05

Also known as: Trazodon · Brand names: Trittico, Trazaxiro, Azona, Desyrel, Trumıo, Raldesy TM

Key facts
Active substance
Trazodone
Drug class
Antidepressant
ATC code
N06AX05
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Boxed warning

Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors [see Warnings and Precautions (5.1)]. Trazodone hydrochloride tablets are not approved for use in pediatric patients [see Use in Specific Populations (8.4)].

Key facts

Trazodone is an antidepressant used to treat major depressive disorder (MDD) in adults.

What it is used for

  • Major depressive disorder in adults
  • Not approved for pediatric patients

Dosing

  • Initial dose 150 mg/day in divided doses; start low and increase gradually
  • Increase by 50 mg/day every 3 to 4 days
  • Outpatients usually not above 400 mg/day, inpatients not above 600 mg/day (divided doses)
  • Drowsiness may require most of the dose at bedtime or a dose reduction; taken shortly after a meal or light snack
  • Strong CYP3A4 inhibitors: consider dose reduction; strong inducers: consider dose increase
  • At least 14 days between MAOIs and trazodone; gradual discontinuation

Contraindications

  • Taking MAOIs (including linezolid or intravenous methylene blue) or within 14 days of stopping them

Important warnings

  • Boxed warning: antidepressants increased suicidal thoughts and behaviors in pediatric and young adult patients; close monitoring
  • Serotonin syndrome, cardiac arrhythmias, orthostatic hypotension and syncope
  • Increased risk of bleeding; priapism
  • Activation of mania/hypomania; screening for bipolar disorder before starting
  • Cognitive and motor impairment, angle-closure glaucoma, hyponatremia

Side effects

  • Common: drowsiness, dizziness/light-headedness, dry mouth, headache, nausea/vomiting, blurred vision
  • Others: constipation, fatigue, nervousness, hypotension, syncope, confusion
  • Serious: priapism, cardiac arrhythmias, serotonin syndrome

Interactions

  • MAOIs contraindicated; other serotonergic drugs increase the risk of serotonin syndrome
  • Strong CYP3A4 inhibitors and inducers alter trazodone exposure

Pregnancy and breastfeeding

  • Studies over several decades have not identified drug-associated risks of major birth defects, miscarriage or adverse outcomes

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

Patient information (US) →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • TritticoAngelini Pharma Oesterreich Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • TrazaxiroMedical Valley Invest Ab · 1 register entry
  • TrazodonHexal Ag, Neuraxpharm Arzneimittel Gmbh, Pharmaclan S.R.O., Glenmark Arzneimittel Gmbh, Stadapharm Gmbh, Aliud Pharma Gmbh · 6 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • AzonaSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • DesyrelANGELİNİ İLAÇ SAN. VE TİC. A.Ş. · 14 register entries
  • TrumıoWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • Raldesy TMValidus Pharmaceuticals LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 21 more European countries
Belgium
Nestrolan, Trazodone Eg, Trazodone Teva
Bulgaria
Тритико
Croatia
Trittico
Cyprus
Trazodone Mc, Trazodone Synto
Czechia
Azoneurax, Trazodon, Trittico Ac, Trittico Prolong
Finland
Azona
Greece
Trittico, Zotrad
Hungary
Trittico Ac, Trittico Xr
Ireland
Molipaxin, Trazodone Hydrochloride Accord Healthcare, Trazodone Hydrochloride Azure, Trazodone Hydrochloride Brillpharma (Ireland), Trazodone Hydrochloride Lexon Pharmaceuticals (Ireland)
Italy
Trazodone Eg, Trittico
Latvia
Trittico Retard
Lithuania
Trittico Retard
Luxembourg
Trazodone Eg
Malta
Trazodone Hydrochloride Azure, Trazodone Hydrochloride Syri Pharma, Trazodone Normon
Netherlands
Trazodon Hcl Sandoz, Trazodon Hcl Xiromed, Trazodon Hydrochloride Accord, Trazodone Hcl Genrx, Trazodone Hcl Sandoz
Poland
Azoneurax, Trazodone Neuraxpharm, Trittico Cr, Trittico Xr
Portugal
Trazodona Farmoz, Trazodona Generis, Trazodona Ratiopharm, Trazone Ac, Trazone Od, Triticum
Romania
Trittico Ac, Trittico Ep
Slovakia
Azoneurax, Trittico Ac
Slovenia
Trittico
Spain
Depraser, Deprax, Trazodona Cinfa, Trazodona Combix, Trazodona Normon, Trazodona Stada, Trazodona Stadafarma

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Trazodone Hydrochloride (Apotex Corp) – Prescribing Information, 2026-03-24. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=71961ab1-951d-1493-f76c-2ff25cca2a85
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC N06AX.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.