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Tiotropium

Braltus, Spiriva, Tiotropium Glenmark, Tiotropium Stada · ATC code R03BB04

Also known as: Tiotropiumbromid, Tiotropiyum bromür, Spiriva HandiHaler · Brand names: Braltus, Spiriva, Tiotropium Glenmark, Tiotropium Stada, Tiotropium Viatris, Acopair, Tiotropium Aaa-Pharma, Tiotropium Al, Tiotropium Elpen, Airtio, Brontio, Coriva, Daytio, Spiract, Tioday Capsair …

Key facts
Active substance
Tiotropium
Drug class
Anticholinergic
ATC code
R03BB04
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-29

Key facts

Tiotropium bromide is a long-acting inhaled anticholinergic. Per the US prescribing information, the inhalation powder is used for maintenance treatment of bronchospasm in COPD and to reduce exacerbations.

What it is used for

  • Long-term, once-daily maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema
  • Reduction of COPD exacerbations

Dosing

  • For oral inhalation only: two inhalations of the powder contents of one capsule once daily with the HandiHaler device
  • Each capsule contains 18 mcg of tiotropium; do not swallow the capsules; use only with the HandiHaler
  • Do not take more than one dose in 24 hours
  • No dose adjustment for geriatric, hepatically or renally impaired patients; with moderate to severe renal impairment (creatinine clearance below 60 mL/min) monitor closely for anticholinergic effects

Contraindications

  • Hypersensitivity to tiotropium, ipratropium or any component of the product

Important warnings

  • Not for acute use or as rescue therapy for acute bronchospasm
  • Immediate hypersensitivity reactions such as angioedema, urticaria, bronchospasm, anaphylaxis; caution with atropine hypersensitivity and severe milk protein hypersensitivity
  • Paradoxical bronchospasm may occur; treat immediately with a short-acting beta2-agonist and stop the drug
  • Worsening of narrow-angle glaucoma (e.g. eye pain, blurred vision, visual halos)
  • Worsening of urinary retention, especially with prostatic hyperplasia or bladder-neck obstruction

Side effects

  • Most commonly dry mouth, usually mild and often resolving
  • Other anticholinergic effects: constipation, tachycardia, blurred vision, glaucoma, dysuria, urinary retention

Interactions

  • Other anticholinergic drugs: additive effects; avoid coadministration
  • Used with beta-agonists, methylxanthines and oral and inhaled steroids without increases in adverse reactions

Pregnancy and breastfeeding

  • Limited human data are insufficient to inform risk; no structural abnormalities in animal studies

Summary of the official product information, written with AI on 2026-10-29. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • BraltusTeva B.V · 1 register entry
  • SpirivaBoehringer Ingelheim International Gmbh · 2 register entries
  • Tiotropium GlenmarkGlenmark Arzneimittel Gmbh · 1 register entry
  • Tiotropium StadaStada Arzneimittel Gmbh · 1 register entry
  • Tiotropium ViatrisViatris Limited · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Germany

  • AcopairViatris Healthcare Gmbh · 1 register entry
  • BraltusTeva Gmbh · 2 register entries
  • SpirivaBoehringer Ingelheim International Gmbh · 2 register entries
  • Tiotropium Aaa-PharmaAaa-Pharma Gmbh · 1 register entry
  • Tiotropium AlAliud Pharma Gmbh · 2 register entries
  • Tiotropium ElpenElpen Pharmaceutical Co. Inc. · 1 register entry
  • Tiotropium GlenmarkGlenmark Arzneimittel Gmbh · 1 register entry
  • Tiotropium StadaStadapharm Gmbh, Stada Arzneimittel Ag · 4 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Turkey

  • AirtioNEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • BrontioDEVA HOLDİNG A.Ş. · 3 register entries
  • CorivaABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • DaytioNEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
  • SpiractHUMANİS SAĞLIK A.Ş. · 2 register entries
  • SpirivaBOEHRİNGER INGELHEİM İLAÇ TİC. A.Ş. · 1 register entry
  • Tioday CapsairNEUTEC İLAÇ SAN. TİC. A.Ş · 3 register entries
  • TiofixNEUTEC İLAÇ SAN. TİC. A.Ş · 2 register entries
  • TionexVİTALİS İLAÇ SAN. TİC. A.Ş. · 3 register entries
  • Tiotek DiscairCELTİS İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • TioumitARIMED İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • Tutast ArvohalerMONTERO İLAÇ VE GIDA SAN. VE TİC. A.Ş. · 2 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • Spiriva HandiHalerBoehringer Ingelheim Pharmaceuticals, Inc. · 3 register entries
  • Spiriva RespimatBoehringer Ingelheim Pharmaceuticals, Inc. · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-29

Brand names in 28 more European countries
Belgium
Spiriva, Tiotraxa
Bulgaria
Бралтус, Плубром, Спирива, Флувент
Croatia
Braltus, Plubir, Spiriva, Triola
Cyprus
Spiriva, Tioresp
Czechia
Gartior, Spiriva, Tiotropium Polpharma
Denmark
Braltus, Spiriva, Tiogiva, Tiotropium Adoh, Tiotropium Stada
Estonia
Spiriva Respimat
Finland
Spiriva, Tiogiva, Tiotropium Stada
France
Spiriva, Tiotropium Eg, Tiotropium Eolip Biogaran, Tiotropium Vertical-Haler Eg, Tiotropium Viatris
Greece
Spiriva, Tioresp, Tiotraxa, Tiotropium Stada, Tiotropium/Stada Stada, Tiovivo
Hungary
Braltus, Ontipria, Spiriva
Iceland
Braltus, Spiriva, Tiotropium Stada
Ireland
Braltus, Spiriva, Tiogiva, Tiotropium Clonmel
Italy
Sirkava, Spiriva, Tiotropio Doc, Tiotropio Eg, Tiotropio Glenmark, Tiotropio Teva Italia, Tiotropio Zentiva
Latvia
Spiriva
Liechtenstein
Spiriva
Lithuania
Spiriva
Luxembourg
Spiriva, Tiotraxa
Malta
Spiriva
Netherlands
Scinorus, Spiriva, Srivasso, Tavulus, Tiotropium Adoh, Tiotropium Cf, Tiotropium Elpen, Tiotropium Focus Care, Tiotropium Viatris, Tiotrus
Norway
Braltus, Spiriva, Tiogiva, Tiotropium Stada
Poland
Braltus, Gartior, Lungamo, Nuodil, Ontipria, Spiriva, Srivasso, Tiobro
Portugal
Braltus, Brometo De Tiotrópio Stada, Gregal, Sirkava, Spiriva, Srivasso
Romania
Dilochob, Gregal, Spiriva
Slovakia
Spiriva, Tiotropium Glenmark
Slovenia
Spiriva
Spain
Braltus, Gregal, Sirkava, Spiriva, Tavulus
Sweden
Braltus, Sirkava, Spiriva, Tiogiva, Tiotropium Stada

EMA – Article 57 product data (EU/EEA), 2026-10-29

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Spiriva HandiHaler (Boehringer Ingelheim Pharmaceuticals, Inc.) – Prescribing Information, 2025-11-10. DailyMed (NLM), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=820839ef-e53d-47e8-a3b9-d911ff92e6a9
  2. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC R03BB.

Editorial: Medelix editorial team · last updated 2026-10-29 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.