tenofovir disoproxil
Viread · ATC code J05AF07
Also known as: Tenofovirdisoproxil · Brand names: Viread, Tenofovir Disoproxil Accordpharma, Tenofovir Ratiopharm, Tenofovir Sandoz, Tenofovirdisoproxil Stada, Tenofovirdisoproxil Accord, Tenofovirdisoproxil Al, Tenofovirdisoproxil Amarox, Tenofovirdisoproxil Aristo, Tenofovirdisoproxil Beta, Tenofovirdisoproxil Cipla, Tenofovirdisoproxil Glenmark, Tenofovirdisoproxil Heumann, Tenofovirdisoproxil Macleods, Tenofovirdisoproxil Oresund Pharma Aps …
- Key facts
- Active substance
- tenofovir disoproxil
- Drug class
- Direct acting antiviral
- ATC code
- J05AF07
- Authorisation
- centrally authorised across the EU (EMA)
- Dosage forms
- Viread 123 mg film-coated tablets · Viread 163 mg film-coated tablets · Viread 204 mg film-coated tablets · Viread 245 mg film-coated tablets · Viread 33 mg/g granules
- Marketing authorisation holder
- Gilead Sciences Ireland UC
- Information as of
- 2026-10-27
Key facts
Tenofovir disoproxil is a nucleotide reverse transcriptase inhibitor used for HIV-1 infection (in combination) and chronic hepatitis B in adults and children.
What it is used for
- HIV-1 infection in adults in combination with other antiretrovirals
- HIV-1 infection in children and adolescents with NRTI resistance or toxicities precluding first-line agents
- Chronic hepatitis B in adults with compensated or decompensated liver disease or lamivudine-resistant HBV
- Chronic hepatitis B in children and adolescents with compensated liver disease and immune active disease
Dosing
- Viread 245 mg (adolescents 12 to <18 years, ≥35 kg): 245 mg once daily with food.
- Children 6 to <12 years: 123 mg (17 to <22 kg), 163 mg (22 to <28 kg) or 204 mg (28 to <35 kg) once daily with food.
- Granules 33 mg/g: children 2 to <12 years 6.5 mg/kg once daily, and for those unable to swallow tablets.
- Adults with CrCl <50 ml/min: reduced daily dose with granules recommended; at 30-49 ml/min, 245 mg every 48 hours as an alternative.
- Duration in hepatitis B depends on HBe/HBs seroconversion (see full text).
Contraindications
- Hypersensitivity to the active substance or any excipient
Important warnings
- Renal effects (renal failure, hypophosphataemia, proximal tubulopathy/Fanconi syndrome); monitor renal function
- Bone abnormalities, infrequently contributing to fractures
- Acute exacerbation of hepatitis during and after stopping hepatitis B therapy
- Offer HIV testing to HBV patients before starting; does not prevent HBV transmission
- High virological failure rate with triple therapy including lamivudine plus abacavir or didanosine
Side effects
- HIV: mostly mild to moderate gastrointestinal events
- Hepatitis B: nausea most frequent (5.4%)
- Rare renal failure; uncommon proximal tubulopathy with bone abnormalities
Interactions
- Do not combine with other tenofovir disoproxil or tenofovir alafenamide products or adefovir dipivoxil
- Didanosine: co-administration not recommended
- Avoid nephrotoxic medicines (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir); cidofovir may raise levels
- Low potential for CYP450-mediated interactions
Pregnancy and breastfeeding
- More than 1,000 pregnancy outcomes show no malformations; may be considered during pregnancy if necessary.
- Third-trimester use, with infant immune globulin and vaccine, has been shown to reduce HBV transmission.
Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
Common questions – ask Medelix
For patients
Package leaflet, verbatim
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
EU – centrally authorised (all member states)
- Tenofovir disoproxil Viatris (previously Tenofovir disoproxil Mylan) · genericViatris Limited · EMEA/H/C/004049
- Tenofovir disoproxil Zentiva · genericZentiva k.s. · EMEA/H/C/004120
- VireadGilead Sciences Ireland UC · EMEA/H/C/000419
Source: European Medicines Agency (EMA), product information
Austria
- Tenofovir Disoproxil AccordpharmaAccord Healthcare B.V. · 1 register entry
- Tenofovir RatiopharmTeva B.V · 1 register entry
- Tenofovir SandozSandoz Gmbh · 1 register entry
- Tenofovirdisoproxil StadaStada Arzneimittel Gmbh · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Germany
- Tenofovirdisoproxil AccordAccord Healthcare B.V. · 1 register entry
- Tenofovirdisoproxil AlAliud Pharma Gmbh · 1 register entry
- Tenofovirdisoproxil AmaroxAmarox Pharma Gmbh · 1 register entry
- Tenofovirdisoproxil AristoAristo Pharma Gmbh (Art 57) · 1 register entry
- Tenofovirdisoproxil BetaBetapharm Arzneimittel Gmbh · 1 register entry
- Tenofovirdisoproxil CiplaCipla Europe Nv · 1 register entry
- Tenofovirdisoproxil GlenmarkGlenmark Arzneimittel Gmbh · 1 register entry
- Tenofovirdisoproxil HeumannHeumann Pharma Gmbh & Co. Generica Kg · 1 register entry
- Tenofovirdisoproxil MacleodsMacleods Pharma España, S.L.U · 1 register entry
- Tenofovirdisoproxil Oresund Pharma ApsOresund Pharma Aps · 1 register entry
- Tenofovirdisoproxil PurenPuren Pharma Gmbh & Co. Kg · 1 register entry
- Tenofovirdisoproxil QiluQilu Pharma Spain S.L. · 1 register entry
Show all 14 brand names
- Tenofovirdisoproxil RatiopharmRatiopharm Gmbh · 1 register entry
- Tenofovirdisoproxil ZentivaZentiva Pharma Gmbh · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Turkey
- AbavirDROGSAN İLAÇLARI SAN. VE TİC. A.Ş. · 2 register entries
- ArisovirALİ RAİF İLAÇ SAN. A.Ş. · 1 register entry
- EvasifSANTA FARMA İLAÇ SAN. A.Ş. · 1 register entry
- HepaproxGENVEON İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- HiveracİLKO İLAÇ SAN.VE TİC. A.Ş. · 2 register entries
- NefovirFARMA-TEK İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- OvirproxilDEVA HOLDİNG A.Ş. · 1 register entry
- SotacarTRIPHARMA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- TenevirBİLİM İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- TenoviralABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- TenribelNOBEL İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- TernavirATABAY KİMYA SAN. VE TİC. A.Ş. · 1 register entry
Show all 18 brand names
- VeforixVEFA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- VireadGİLEAD SCİENCES İLAÇ TİC. LTD. ŞTİ. · 1 register entry
- VirsoemWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- VirtenixHUMANİS SAĞLIK A.Ş. · 2 register entries
- VoxusSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- ZentovirSANOFİ İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
Brand names in 22 more European countries
- Bulgaria
- Тенофовир Зентива, Тенофовир Полфарма
- Croatia
- Teynofor
- Cyprus
- Tenoviral
- Czechia
- Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Teva, Tenofovir Disoproxil Zentiva K.S.
- Denmark
- Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Glenmark, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Stada, Tenofovir Disoproxil Teva, Tenofovir Disoproxil Zentiva K.S
- Estonia
- Tenofovir Disoproxil Sandoz
- Finland
- Tenofovir Disoproxil Hexal, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Stada
- France
- Tenofovir Disoproxil Accord, Tenofovir Disoproxil Arrow, Tenofovir Disoproxil Biogaran, Tenofovir Disoproxil Eg, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Zentiva Lab, Tenofovir Disoproxil Zydus, Ténofovir Disoproxil Teva
- Greece
- Agardon, Tenofovir Disoproxil Accord Pharma, Tenofovir Disoproxil Vocate
- Hungary
- Tenofovir Disoproxil Accordpharma, Tenofovir Onkogen, Tenofovir Teva, Virofob
- Iceland
- Tenofovir Disoproxil Viatris, Tenofovir Disoproxil Zentiva, Viread, Virofob
- Ireland
- Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Teva
- Italy
- Tenofovir Disoproxil Aurobindo, Tenofovir Disoproxil Doc Generici, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Teva
- Latvia
- Tenofovir Disoproxil Teva
- Liechtenstein
- Tenofovir Disoproxil Viatris, Tenofovir Disoproxil Zentiva, Viread
- Netherlands
- Tenofovir Disoproxil Accord, Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Amarox, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Vocate, Tenofovir Disoproxyl Fumarate Aurobindo, Tenofovirdisoproxil Doc Generici, Tenofovirdisoproxil Glenmark, Tenofovirdisoproxil Medicopharm, Tenofovirdisoproxil Teva
- Norway
- Filmdrasjerte Tabletter Viatris, Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Teva, Tenofovir Disoproxil Viatris, Tenofovir Disoproxil Zentiva, Viread
- Poland
- Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Aurovitas, Tenofovir Polpharma, Tenofovir Zentiva
- Portugal
- Tenofovir Accord, Tenofovir Aurobindo, Tenofovir Aurovitas, Tenofovir Farmoz, Tenofovir Teva
- Romania
- Tenofovir Disoproxil Accord, Tenofovir Disoproxil Accordpharma, Tenofovir Stada, Virofob
- Spain
- Tenofovir Disoproxilo Accordpharma, Tenofovir Disoproxilo Aurovitas, Tenofovir Disoproxilo Cipla, Tenofovir Disoproxilo Glenmark, Tenofovir Disoproxilo Macleods, Tenofovir Disoproxilo Qilu, Tenofovir Disoproxilo Teva
- Sweden
- Tenofovir Disoproxil Accordpharma, Tenofovir Disoproxil Glenmark, Tenofovir Disoproxil Sandoz, Tenofovir Disoproxil Stada, Tenofovir Disoproxil Teva, Tenofovirdisoproxil Oresund Pharma Aps
EMA – Article 57 product data (EU/EEA), 2026-10-28
Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.
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Sources
- European Medicines Agency. Viread – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/viread-epar-product-information_en.pdf
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- Wikidata (CC0): ATC J05AF.
Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error
Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.