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Sumatriptan

Amigro, Imigran, Sumatriptan · ATC code N02CC01

Brand names: Amigro, Imigran, Migrapen, Tempil, Imitrex, Tosymra, Zembrace SymTouch

Key facts
Active substance
Sumatriptan
Drug class
Antimigraine
ATC code
N02CC01
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Sumatriptan is a 5-HT1 agonist (triptan). According to the US prescribing information (IMITREX tablets), it is used for the acute treatment of migraine with or without aura in adults.

What it is used for

  • Acute treatment of migraine with or without aura in adults
  • Only when a clear diagnosis of migraine has been established
  • Not for migraine prevention; safety and effectiveness not established for cluster headache

Dosing

  • Tablets: recommended dose 25 mg, 50 mg or 100 mg; 100 mg may not provide a greater effect than 50 mg
  • If migraine persists or returns: a second dose at least 2 hours after the first
  • Maximum daily dose 200 mg in a 24-hour period
  • After IMITREX injection: additional single tablets up to 100 mg/day, at least 2 hours apart
  • Mild to moderate hepatic impairment: maximum single dose 50 mg
  • Safety of treating more than 4 headaches on average in a 30-day period not established

Contraindications

  • Ischemic coronary artery disease or coronary vasospasm, including Prinzmetal's angina
  • Wolff-Parkinson-White syndrome or arrhythmias with accessory conduction pathways
  • History of stroke or TIA, or hemiplegic or basilar migraine
  • Peripheral vascular disease, ischemic bowel disease, uncontrolled hypertension
  • Ergot-type drugs or another 5-HT1 agonist within 24 hours; MAO-A inhibitor concurrently or within 2 weeks
  • Severe hepatic impairment; hypersensitivity

Important warnings

  • Myocardial ischemia, myocardial infarction and Prinzmetal's angina, rarely in patients without known CAD; cardiovascular evaluation in triptan-naive patients with multiple risk factors
  • Arrhythmias and chest, throat, neck or jaw pain/tightness/pressure
  • Cerebrovascular events and other vasospasm reactions
  • Medication overuse headache
  • Serotonin syndrome, particularly with SSRIs, SNRIs, TCAs and MAO inhibitors
  • Increase in blood pressure, including hypertensive crisis; monitor blood pressure

Side effects

  • Atypical sensations such as paresthesia and warm/cold sensation
  • Pain and pressure sensations, including chest, neck, throat or jaw
  • Serious: myocardial ischemia/infarction, arrhythmias, stroke, serotonin syndrome, hypersensitivity reactions, seizures

Interactions

  • Ergotamine-containing or ergot-type drugs (e.g. dihydroergotamine, methysergide) within 24 hours: contraindicated
  • MAO-A inhibitors markedly increase systemic exposure: contraindicated
  • Other 5-HT1 agonists (triptans) within 24 hours: contraindicated
  • SSRIs/SNRIs: risk of serotonin syndrome

Pregnancy and breastfeeding

  • Pregnancy: a pregnancy registry and epidemiological studies did not detect an increased frequency of birth defects; embryolethality and fetal abnormalities in animal studies
  • Lactation: sumatriptan is excreted in human milk; infant exposure can be minimized by avoiding breastfeeding for 12 hours after treatment

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

Patient information (US) →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • AmigroHexal Pharma Gmbh · 1 register entry
  • ImigranGlaxosmithkline Pharma Gmbh. · 1 register entry
  • Sumatriptan1a Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • ImigranGlaxosmithkline Gmbh & Co. Kg · 5 register entries
  • MigrapenLupin Europe Gmbh · 1 register entry
  • SumatriptanHexal Ag, 1 A Pharma Gmbh, Ratiopharm Gmbh, Cnx Therapeutics Ireland Limited, Dexcel Pharma Ltd, Puren Pharma Gmbh & Co. Kg, Bluefish Pharmaceuticals Ab, Hormosan Pharma Gmbh, Heumann Pharma Gmbh & Co. Generica Kg, Holsten Pharma Gmbh, Stadapharm Gmbh, Betapharm Arzneimittel Gmbh, Viatris Germany Gmbh, Abz-Pharma Gmbh, Aliud Pharma Gmbh · 18 register entries
  • TempilHormosan Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • ImigranGLAXOSMİTHKLİNE İLAÇLARI SAN. VE TİC. A.Ş. · 6 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • ImitrexGlaxoSmithKline LLC · 2 register entries
  • TosymraUpsher-Smith Laboratories, LLC, Tonix Medicines, Inc. · 2 register entries
  • Zembrace SymTouchTonix Medicines, Inc. · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 27 more European countries
Belgium
Imitrex, Sumatriptan Eg, Sumatriptan Sandoz, Sumatriptan Teva, Sumatriptan Viatris
Bulgaria
Амигрен, Имигран, Хедан
Croatia
Imigran, Sumigra
Cyprus
Imigran
Czechia
Frimig, Imigran, Rosemig, Sumatriptan Actavis, Sumatriptan Viatris
Denmark
Damigra, Imigran, Sumatriptan "sandoz", Sumatriptan Accord, Sumatriptan Advanz Pharma, Sumatriptan Bluefish, Sumatriptan Sun, Sumatriptan Teva, Sumatriptan Viatris, Sumore
Estonia
Cinie, Imigran Fdt, Migriptan, Sumatriptan Actavis
Finland
Damigra, Imigran, Oriptan, Sumatriptan
France
Imigrane, Imiject, Sumatriptan Arrow, Sumatriptan Sun, Sumatriptan Teva, Sumatriptan Venipharm
Greece
Forcet, Hedimal, Imigran, Migracor, Suptimist, Sutriptan
Hungary
Cinie, Frimig, Imigran, Sumatriptan Orion, Triptagram
Iceland
Damigra, Imigran, Sumatriptan Apofri, Sumatriptan Bluefish
Ireland
Imigran, Sumatran, Sumatriptan Accord Healthcare Ireland
Italy
Imigran, Sumatriptan Accord, Sumatriptan Aurobindo Italia, Sumatriptan Cnx Therapeutics, Sumatriptan Doc, Sumatriptan Eg, Sumatriptan Mylan, Sumatriptan Sandoz, Sumatriptan Sun, Sumatriptan Teva, Sumatriptan Zentiva
Latvia
Cinie
Lithuania
Cinie, Imigran, Sumatriptan Actavis, Sumatriptan Stada
Luxembourg
Imitrex, Sumatriptan Eg
Malta
Imigran, Sumatriptan Aurobindo
Netherlands
Damigra, Imigran, Sumatriptan Accord, Sumatriptan Advanz Pharma, Sumatriptan Basic Pharma, Sumatriptan Ipca, Sumatriptan Sandoz, Sumatriptan Succinate Aurobindo, Sumatriptan Sun, Sumatriptan Teva, Sumatriptan Viatris
Norway
Damigra, Imigran, Oriptan, Sumatriptan Advanz Pharma, Sumatriptan Bluefish, Sumatriptan Sun, Sumatriptan Teva, Sumore
Poland
Apomigra, Cinie, Frimig, Imigran, Migtan, Sumamigren, Sumanor, Sumatriptan Medical Valley, Sumatriptan Sun, Sumatriptan Us Pharmacia
Portugal
Imigran
Romania
Imigran Dr, Sumacta, Sumatriptan Sun, Xibimer
Slovakia
Cinie, Imigran, Sumatriptan Sandoz
Slovenia
Imigran
Spain
Imigran, Sumatriptan Cfourhealth, Sumatriptán Aurovitas, Sumatriptán Klaria, Sumatriptán Sandoz, Sumatriptán Sun, Sumatriptán Teva, Sumatriptán Viatris
Sweden
Damigra, Imigran, Oriptan, Sumatriptan Abece, Sumatriptan Accord, Sumatriptan Advanz Pharma, Sumatriptan Apofri, Sumatriptan Bluefish, Sumatriptan Mylan, Sumatriptan Orion, Sumatriptan Punkt Evolan Phrma, Sumatriptan Sandoz, Sumatriptan Sun, Sumatriptan Teva, Sumore

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. U.S. Food and Drug Administration. IMITREX (GlaxoSmithKline LLC) – Prescribing Information, 2025-12-09. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=584abe73-8290-4484-ff8e-5890831c095e
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC N02CC.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.