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Minocycline

Minostad · ATC code A01AB23

Also known as: Minocyclin, Minosiklin · Brand names: Minostad, Minoplus, Skid, Amzeeq, Arestin, Emrosi, Minocin, Zilxi

Key facts
Active substance
Minocycline
Drug class
Medications used in dentistry and periodontics
ATC code
A01AB23
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-29

Key facts

Minocycline is a tetracycline-class antibiotic. Per the US prescribing information, the capsules are used for a range of infections caused by susceptible bacteria, including rickettsial, chlamydial, mycoplasma and certain gram-negative and gram-positive infections.

What it is used for

  • Rickettsial infections (e.g. Rocky Mountain spotted fever, typhus, Q fever), Mycoplasma pneumoniae respiratory infections
  • Chlamydia and Ureaplasma infections (e.g. nongonococcal urethritis, trachoma, lymphogranuloma venereum), psittacosis
  • Plague, tularemia, cholera, brucellosis (with streptomycin), relapsing fever, chancroid and other listed infections
  • Certain gram-negative and gram-positive infections when susceptibility is shown; an alternative when penicillin is contraindicated (e.g. gonococcal infections, syphilis)

Dosing

  • Adults: 200 mg initially, then 100 mg every 12 hours; may be taken with or without food, with adequate fluids, swallowed whole
  • Children above 8 years: 4 mg/kg initially, then 2 mg/kg every 12 hours, not exceeding the adult dose
  • Examples: gonococcal urethritis in men 100 mg every 12 hours for 5 days; chlamydial or ureaplasma infection 100 mg every 12 hours for at least 7 days – other regimens see the full text
  • Renal impairment: total daily dose should not exceed 200 mg in 24 hours; monitor BUN and creatinine

Contraindications

  • Hypersensitivity to any tetracycline or to any component of the product

Important warnings

  • Use during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent tooth discoloration; can cause fetal harm
  • Hepatotoxicity, including autoimmune hepatitis and fatal liver failure
  • DRESS, including fatal cases; photosensitivity
  • CNS effects (lightheadedness, dizziness, vertigo) – caution when driving
  • Intracranial hypertension (pseudotumor cerebri), possibly with permanent visual loss
  • Clostridioides difficile-associated diarrhea; overgrowth of non-susceptible organisms

Side effects

  • Anorexia, nausea, vomiting, diarrhea, dyspepsia, stomatitis, esophagitis
  • Rash, photosensitivity, pigmentation of skin and mucous membranes, erythema multiforme, Stevens-Johnson syndrome
  • Lightheadedness, dizziness, vertigo, headache
  • Liver toxicity, interstitial nephritis, blood disorders

Interactions

  • Anticoagulants: dose reduction may be needed (reduced prothrombin activity)
  • Penicillin: avoid combination
  • Antacids with aluminum, calcium or magnesium and iron preparations impair absorption
  • Oral contraceptives may be less effective
  • Isotretinoin: avoid (risk of pseudotumor cerebri)

Pregnancy and breastfeeding

  • Can cause fetal harm; tetracyclines cross the placenta and may retard skeletal development

Summary of the official product information, written with AI on 2026-10-29. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • MinostadStada Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Germany

  • MinoplusChephasaar Chemisch-Pharmazeutische Fabrik Gmbh · 1 register entry
  • SkidWinthrop Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

USA

  • AmzeeqJourney Medical Corporation · 1 register entry
  • ArestinOraPharma, Inc. · 1 register entry
  • EmrosiJourney Medical Corporation · 1 register entry
  • MinocinMelinta Therapeutics, LLC · 1 register entry
  • ZilxiJourney Medical Corporation · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-29

Brand names in 13 more European countries
Belgium
Klinotab, Mino-50, Minocycline Eg, Minotab
Bulgaria
Миноциклин Екофарм
Cyprus
Minaxen
France
Kyno, Mynocine, Parocline
Greece
Minocin
Ireland
Minocin Sa, Minosil
Italy
Minocin
Luxembourg
Klinotab, Mino, Minocycline Eg, Minotab
Malta
Minaxen
Netherlands
Minocycline Eurogenerics, Minocycline Hydrochloride Dihydrate Aurobindo
Portugal
Cipancin, Minocin, Minotrex
Romania
Minoz Ep
Spain
Minocin Vía

EMA – Article 57 product data (EU/EEA), 2026-10-29

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Minocycline hydrochloride (Zydus Pharmaceuticals USA Inc.) – Prescribing Information, 2025-04-26. DailyMed (NLM), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=25acb785-6838-4e62-9e86-ddc30b2b759a
  2. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/
  5. Wikidata (CC0): ATC A01AB.

Editorial: Medelix editorial team · last updated 2026-10-29 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.