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Lorazepam

Lorazepam Macure, Temesta, Xilmac · ATC code N05BA06

Brand names: Lorazepam Macure, Temesta, Xilmac, Lorazepam Aristo, Lorazepam Dura, Lorazepam Hualan, Lorazepam Medochemie Bohemia, Lorazepam Neuraxpharm, Lorazepam Xilmac Macure Healthcare, Tavor, Zambaxo, Ativan Expidet, Ativan, Loreev XR

Key facts
Active substance
Lorazepam
Drug class
Benzodiazepine drug
ATC code
N05BA06
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Boxed warning

  • Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation (see WARNINGS and PRECAUTIONS).
  • The use of benzodiazepines, including lorazepam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing lorazepam and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction (see WARNINGS).
  • The continued use of benzodiazepines, including lorazepam, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of lorazepam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue lorazepam or reduce the dosage (DOSAGE AND ADMINISTRATION and WARNINGS).

Key facts

Lorazepam is a benzodiazepine. The tablets are used to manage anxiety disorders and for short-term relief of anxiety symptoms, including anxiety associated with depressive symptoms.

What it is used for

  • Management of anxiety disorders
  • Short-term relief of anxiety symptoms or anxiety associated with depressive symptoms
  • Effectiveness in long-term use (more than 4 months) not systematically assessed

Dosing

  • Usual range 2 to 6 mg/day in divided doses, largest dose before bedtime; daily dose may vary from 1 to 10 mg/day
  • Anxiety: initial dose usually 2 to 3 mg/day given two or three times a day
  • Insomnia due to anxiety or situational stress: 2 to 4 mg once daily, usually at bedtime
  • Elderly or debilitated patients: initial 1 to 2 mg/day in divided doses
  • Lower initial dose in patients on opioids; discontinue or reduce only by gradual taper

Contraindications

  • Hypersensitivity to benzodiazepines or any formulation component
  • Acute narrow-angle glaucoma

Important warnings

  • Boxed warning: use with opioids may cause profound sedation, respiratory depression, coma and death
  • Boxed warning: risks of abuse, misuse and addiction, which can lead to overdose or death
  • Boxed warning: physical dependence; abrupt discontinuation may cause life-threatening withdrawal reactions
  • Caution in compromised respiratory function (e.g. COPD, sleep apnea) and in depression (suicide risk)
  • Elderly or debilitated patients may be more susceptible to sedation

Side effects

  • Most frequent: sedation (15.9%), dizziness (6.9%), weakness (4.2%), unsteadiness (3.4%); sedation and unsteadiness increase with age
  • Fatigue, amnesia, confusion, depression, disinhibition, ataxia
  • Respiratory depression, apnea, worsening of sleep apnea
  • Blood dyscrasias, liver enzyme increases, hyponatremia

Interactions

  • Opioids: increased risk of respiratory depression, sedation, coma and death
  • Alcohol and other CNS depressants: additive effects and more serious outcomes with misuse

Pregnancy and breastfeeding

  • Use late in pregnancy can cause neonatal sedation (respiratory depression, hypotonia) and/or withdrawal symptoms
  • Breastfed infants should be monitored for excessive sedation, poor feeding and poor weight gain

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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Patient information (US)

Patient information (US) →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • Lorazepam MacureMacure Pharma Aps · 2 register entries
  • TemestaPfizer Corporation Austria Ges.M.B.H. · 1 register entry
  • XilmacMacure Healthcare Limited · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Lorazepam AristoAristo Pharma Gmbh (Art 57) · 1 register entry
  • Lorazepam DuraViatris Germany Gmbh · 1 register entry
  • Lorazepam HualanHualan · 1 register entry
  • Lorazepam MacureMacure Pharma Aps · 1 register entry
  • Lorazepam Medochemie BohemiaMedochemie Bohemia, Spol. S R.O. · 1 register entry
  • Lorazepam NeuraxpharmNeuraxpharm Arzneimittel Gmbh · 1 register entry
  • Lorazepam Xilmac Macure HealthcareMacure Healthcare Limited · 1 register entry
  • TavorPfizer Pharma Gmbh · 3 register entries
  • ZambaxoMacure Healthcare Limited · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • Ativan ExpidetPFİZER PFE İLAÇLARI A.Ş. · 4 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • AtivanBausch Health US LLC · 1 register entry
  • Loreev XR1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 25 more European countries
Belgium
Lambutrix, Lorazepam Ab, Lorazepam Eg, Lorazepam Macure, Lorazepam Medochemie Bohemia, Odflix, Serenase, Temesta
Bulgaria
Лоразепам Tzf, Лорапам, Темелор
Croatia
Lorsilan, Temelor
Cyprus
Lorans, Lorivan, Temelor
Czechia
Temelor
Denmark
Lorazepam Macure, Lorazepam Orion, Rativor
Estonia
Lorans, Temelor
Finland
Lorazepam Macure, Lorazepam Orion, Rativor, Temesta
France
Lorazepam Arrow, Lorazepam Viatris, Lorazepam Xilmac Macure, Temesta
Greece
Akivass, Dorm, Tavor, Titus, Trankilium
Hungary
Loranxil, Lorazepam Orion, Lorazepam Tzf
Ireland
Ativan, Lorazepam Aspire Pharma (Malta), Lorazepam Macure, Xilmac
Italy
Control, Lorans, Lorazepam Abc, Lorazepam Accord, Lorazepam Almus, Lorazepam Alter, Lorazepam Aurobindo, Lorazepam Doc, Lorazepam Dorom, Lorazepam Eg, Lorazepam Hualan, Lorazepam Macure, Lorazepam Mylan Generics, Lorazepam Pensa, Lorazepam Ratiopharm, Lorazepam Sandoz, Lorazepam Tecnigen, Lorazepam Zentiva, Lorxagen, Tavor
Latvia
Lorafen, Lorazepam Macure, Lorazepam Sanoswiss, Lorazepam Tzf, Temelor
Lithuania
Dalixen, Lirezid, Lorafen, Lorans, Lorazepam Macure, Lorazepam Polfa Tarchomin, Lorazepam Polta, Lorazepam Sanoswiss, Lorazepam Tzf
Luxembourg
Lambutrix, Lorazepam Eg, Temesta
Malta
Ativan, Lorivan, Temelor
Netherlands
Lambutrix, Lorazepam Accord Healthcare, Lorazepam Auro, Lorazepam Aurobindo, Lorazepam Cf, Lorazepam Genrx, Lorazepam Hualan, Lorazepam Ibsa Farmaceutici, Lorazepam Macure, Lorazepam Medochemie Bohemia, Lorazepam Medochemie Romania, Lorazepam Prolepha, Lorazepam Tzf, Odflix, Temelor, Xilmac, Zambaxo
Norway
Lorazepam Macure, Rativor
Poland
Lorabex, Lorafen, Lorazepam Orion, Lorazepam Tzf
Portugal
Ansilor, Lorazepam Aristo, Lorazepam Aurobindo, Lorazepam Aurovitas, Lorazepam Bluepharma, Lorazepam Generis, Lorazepam Hualan, Lorazepam Labesfal, Lorazepam Limeg, Lorazepam Pharmakern, Lorazepam Ritisca, Lorazepam Tzf, Lorazepam Vitória, Lorenin, Lorsedal, Odflix, Rialam, Temelor
Romania
Anxiar, Temelor
Slovenia
Lorazepam Macure, Lorsilan
Spain
Lorazepam Aurovitas, Lorazepam Cinfa, Lorazepam Desgen, Lorazepam Hualan, Lorazepam Kern Pharma, Lorazepam Normon, Lorazepam Pensa, Lorazepam Vir, Orfidal, Temelor
Sweden
Lorazepam Macure, Lorazepam Orion, Rativor, Temesta

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. LORAZEPAM (Aurolife Pharma LLC) – Prescribing Information, 2025-12-11. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5b851f67-309d-4ef3-8b4b-ade8908256ea
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC N05BA.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.