Linezolid
Ilenozyd, Linezolid, Zyvoxid · ATC code J01XX08
Brand names: Ilenozyd, Zyvoxid, Limexid, Linedor, Linejcet, Linexolid, Linezone, Lizorex, Lynozid, Multiflex Linezosel, Nodizil, Polinoksid, Zizolid, Zyvox
- Key facts
- Active substance
- Linezolid
- ATC code
- J01XX08
- Authorisation
- authorised nationally; no central EU authorisation
- Information as of
- 2026-10-29
Key facts
Linezolid is, per the US prescribing information, an oxazolidinone antibiotic used to treat pneumonia, skin and skin structure infections and vancomycin-resistant Enterococcus faecium infections.
What it is used for
- Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and -resistant) or Streptococcus pneumoniae.
- Community-acquired pneumonia caused by Streptococcus pneumoniae (including with bacteremia) or methicillin-susceptible Staphylococcus aureus.
- Complicated and uncomplicated skin and skin structure infections (including diabetic foot infections without osteomyelitis) caused by susceptible organisms.
- Vancomycin-resistant Enterococcus faecium infections.
- Not indicated for Gram-negative infections.
Dosing
- Adults and adolescents 12 years and older: 600 mg every 12 hours for 10 to 14 days (pneumonia, complicated skin infections) or 14 to 28 days (VRE infections).
- Uncomplicated skin infections: adults 400 mg, adolescents 600 mg every 12 hours for 10 to 14 days.
- Children from birth through 11 years: 10 mg/kg every 8 hours (every 12 hours for uncomplicated skin infections from 5 years); for pre-term neonates see the full text.
- No dose adjustment when switching from intravenous to oral; use beyond 28 days has not been evaluated in controlled trials.
Contraindications
- Known hypersensitivity to linezolid or other product components.
- Taking monoamine oxidase A or B inhibitors (e.g. phenelzine, isocarboxazid) or within two weeks of such use.
Important warnings
- Myelosuppression (anemia, leukopenia, pancytopenia, thrombocytopenia): monitor blood counts weekly, particularly with treatment longer than two weeks.
- Peripheral and optic neuropathy, mainly with treatment beyond 28 days, sometimes progressing to vision loss; prompt eye examination if visual symptoms occur.
- Serotonin syndrome (including fatal cases) with serotonergic agents.
- Blood pressure elevation in uncontrolled hypertension, pheochromocytoma, thyrotoxicosis or with sympathomimetics (e.g. pseudoephedrine), unless monitored.
- Lactic acidosis, convulsions, rhabdomyolysis, hypoglycemia in diabetics, hyponatremia/SIADH.
- Clostridioides difficile-associated diarrhea.
Side effects
- Most common in adults: headache (up to 8.8%), diarrhea (up to 8.3%), nausea (up to 6.6%), vomiting, dizziness, rash, anemia, taste alteration.
- Postmarketing: anaphylaxis, severe skin reactions, myelosuppression, neuropathies, lactic acidosis, convulsions, rhabdomyolysis.
Interactions
- Linezolid is a reversible, nonselective monoamine oxidase inhibitor.
- Adrenergic agents (sympathomimetics, vasopressors, dopaminergic agents) may raise blood pressure.
- Serotonergic agents (e.g. SSRIs, SNRIs, tricyclic antidepressants, opioids) increase the risk of serotonin syndrome.
Pregnancy and breastfeeding
- Case reports have not identified a drug-associated risk of major birth defects or miscarriage.
- Linezolid is present in breast milk; monitor breastfed infants for diarrhea and vomiting.
Summary of the official product information, written with AI on 2026-10-29. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
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For patients
Patient information (US)
This product has no separate US patient information.
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
Austria
- IlenozydKrka, D.D., Novo Mesto · 1 register entry
- Linezolid1a Pharma Gmbh, Pharmathen S.A., Teva B.V, Accord Healthcare B.V., Sandoz Gmbh, Hikma Farmacêutica (Portugal), S.A., Stada Arzneimittel Gmbh, Demo Abee, Fresenius Kabi Austria Gmbh, Krka, D.D., Novo Mesto, Hcs Bvba · 13 register entries
- ZyvoxidPfizer Corporation Austria Ges.M.B.H. · 2 register entries
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29
Germany
- Linezolid1 A Pharma Gmbh, Dr. Friedrich Eberth Arzneimittel Gmbh, Ratiopharm Gmbh, Panmedica, Glenmark Arzneimittel Gmbh, Kalceks, Zentiva Pharma Gmbh, Accord Healthcare B.V., Amarox Pharma Gmbh, Ascend Gmbh, Helm Pharmaceuticals Gmbh, Hexal Ag, Hikma Farmacêutica (Portugal), S.A., Eugia Pharma (Malta) Limited, Puren Pharma Gmbh & Co. Kg, Stadapharm Gmbh, Demo Abee, Denk Pharma Gmbh & Co. Kg, Fresenius Kabi Deutschland Gmbh, Tad Pharma Gmbh, Aliud Pharma Gmbh · 24 register entries
- ZyvoxidPfizer Pharma Gmbh · 2 register entries
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29
Turkey
- LimexidKOÇAK FARMA İLAÇ VE KİMYA SAN. A.Ş. · 3 register entries
- LinedorVEM İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- LinejcetTÜM-EKİP İLAÇ A.Ş. · 1 register entry
- LinexolidHAVER TRAKYA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
- LinezoneFARMAKO ECZACILIK A.Ş. · 1 register entry
- LizorexFARMA-TEK İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- LynozidWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 4 register entries
- Multiflex LinezoselHAVER FARMA İLAÇ A.Ş. · 2 register entries
- NodizilMENTA PHARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- PolinoksidPOLİFARMA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
- ZizolidBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 7 register entries
- ZyvoxidPFİZER PFE İLAÇLARI A.Ş. · 2 register entries
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
USA
- ZyvoxPharmacia & Upjohn Company LLC, Hp Halden Pharma AS · 5 register entries
Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-29
Brand names in 27 more European countries
- Belgium
- Linezolid Fresenius Kabi, Linezolid Sandoz, Zyvoxid
- Bulgaria
- Linezolid Kabi, Линезолид Крка, Линезолид Полфарма, Линестад
- Croatia
- Linezolid Kabi, Linezolid Krka, Linezolid Pliva, Linezolid Sandoz, Lynz, Zoxilid, Zyvoxid
- Cyprus
- Apel, Linezid, Linezolid Accord, Linezolid Vioser, Zetalid, Zyvoxid
- Czechia
- Linezolid Accord, Linezolid Demo, Linezolid Kabi, Linezolid Kalceks, Linezolid Krka, Linezolid Olikla, Linezolid Sandoz, Zyvoxid
- Denmark
- Linezolid "sandoz", Linezolid Accord, Linezolid Fresenius Kabi, Linezolid Glenmark, Linezolid Krka, Linezolid Teva, Zyvoxid
- Estonia
- Apel, Linezolid Accord, Linezolid Krka, Zyvoxid
- Finland
- Linezolid Accord, Linezolid Krka, Linezolid Sandoz, Zyvoxid
- France
- Linezolide Accord, Linezolide Arrow, Linezolide Demo, Linezolide Eg, Linezolide Hikma, Linezolide Kabi, Linezolide Kalceks, Linezolide Panpharma, Linezolide Stragen, Linézolide Viatris, Zyvoxid
- Greece
- Antizolid, Linesol, Linezan, Linezolid /Kabi, Linezolid Vioser, Lizedia, Zetalid, Zyvoxid
- Hungary
- Anozilad, Linesan, Linezolid Fresenius Kabi, Linezolid Krka
- Iceland
- Zyvoxid
- Ireland
- Linezolid, Zyvox
- Italy
- Linezolid Aurobindo, Linezolid Demo, Linezolid Hikma, Linezolid Kabi, Linezolid Krka, Linezolid S.A.L.F., Linezolid Teva, Zyvoxid
- Latvia
- Apel, Linezolid Accord, Linezolid Inteli, Linezolid Kalceks, Linezolid Krka, Zyvoxid
- Lithuania
- Disenil, Linezolid Accord, Linezolid Inteli, Linezolid Kalceks, Linezolid Krka, Zyvoxid
- Luxembourg
- Linezolid Dr. Eberth, Linezolid Fresenius Kabi, Linezolid Sandoz, Zyvoxid
- Malta
- Apel, Zyvox
- Netherlands
- Dilizolen, Linezolid Accord, Linezolid Fresenius Kabi, Linezolid Mylan, Linezolid Polpharma, Linezolid Sandoz, Linezolid Teva, Zyvoxid
- Norway
- Linezolid Accord, Linezolid Fresenius Kabi, Linezolid Krka, Linezolid Sandoz, Zyvoxid
- Poland
- Dilizolen, Linezolid Eugia, Linezolid Kabi, Linezolid Kalceks, Linezolid Krka, Linezolid Polpharma, Zyvoxid
- Portugal
- Linezolida Accord, Linezolida Accordpharma, Linezolida Altan Pharmaceuticals S.A., Linezolida Anfarm, Linezolida Aurobindo, Linezolida Aurovitas, Linezolida Demo, Linezolida Farmoz, Linezolida Glenmark, Linezolida Hikma, Linezolida Kabi, Linezolida Mylan, Linezolida Normon, Linezolida Teva, Zyvoxid
- Romania
- Linezolid, Zyvoxid
- Slovakia
- Apel, Linezolid Accord, Linezolid Demo, Linezolid Kabi, Linezolid Kalceks, Linezolid Krka, Linezolid Sandoz
- Slovenia
- Linezolid Accord, Linezolid Kabi, Linezolid Krka, Zyvoxid
- Spain
- Apel, Linezolid Accordpharma, Linezolid Altan, Linezolid Aurovitas, Linezolid Demo, Linezolid Glenmark, Linezolid Hikma, Linezolid Kabi, Linezolid Kalceks, Linezolid Krka, Linezolid Normon, Linezolid Sandoz, Linezolid Teva Pharma, Zyvoxid
- Sweden
- Linezolid Accord, Linezolid Glenmark, Linezolid Kalceks, Linezolid Krka, Linezolid Sandoz, Linezolid Teva, Zoxilid, Zyvoxid
EMA – Article 57 product data (EU/EEA), 2026-10-29
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Sources
- U.S. Food and Drug Administration. Linezolid (Macleods Pharmaceuticals Limited) – Prescribing Information, 2026-07-15. DailyMed (NLM), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=90dd8c13-c428-4472-91e5-5b1fcdc4fce3
- EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-29. https://dailymed.nlm.nih.gov/dailymed/
Editorial: Medelix editorial team · last updated 2026-10-29 · How these pages are made · Report an error
Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.