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ivabradine

Corlentor, Ivabradine Anpharm, Procoralan · ATC code C01EB17

Also known as: Ivabradin · Brand names: Corlentor, Ivabradine Anpharm, Procoralan, Ivabradin Aristo, Ivabradin Genericon, Ivabradin Hcs, Ivabradin Ratiopharm, Ivabradin Sandoz, Ivabradin Stada, Ivacorlan, Ivabalan, Ivabranio, Arivadin, Coralan, Covadrin

Key facts
Active substance
ivabradine
ATC code
C01EB17
Authorisation
centrally authorised across the EU (EMA)
Dosage forms
Corlentor 5 mg film-coated tablets / Corlentor 7.5 mg film-coated tablets · Ivabradine Anpharm 5 mg film-coated tablets / Ivabradine Anpharm 7.5 mg film-coated tablets · Procoralan 5 mg film-coated tablets / Procoralan 7.5 mg film-coated tablets
Marketing authorisation holder
Les Laboratoires Servier, "Anpharm" Przedsiębiorstwo Farmaceutyczne S.A.
Information as of
2026-10-27

Key facts

Ivabradine is a heart-rate-lowering agent (Corlentor, Procoralan, Ivabradine Anpharm). It is used for symptomatic treatment of chronic stable angina pectoris and in chronic heart failure.

What it is used for

  • Chronic stable angina in adults with coronary artery disease, sinus rhythm and heart rate ≥ 70 bpm, when beta-blockers are not tolerated/contraindicated or in combination with a beta-blocker
  • Chronic heart failure NYHA II to IV with systolic dysfunction, sinus rhythm and heart rate ≥ 75 bpm, with standard therapy

Dosing

  • Angina: starting dose not above 5 mg twice daily (below 75 years); may be increased after three to four weeks; maintenance not above 7.5 mg twice daily
  • Angina: discontinue if symptoms do not improve within 3 months
  • Heart failure: start 5 mg twice daily; after two weeks 7.5 mg twice daily if resting rate persistently above 60 bpm, or 2.5 mg twice daily if below 50 bpm
  • If resting heart rate falls below 50 bpm or bradycardia symptoms occur, reduce the dose; discontinue if this persists
  • Age 75 years or more: consider a lower starting dose (2.5 mg twice daily); caution with creatinine clearance below 15 ml/min and moderate hepatic impairment

Contraindications

  • Resting heart rate below 70 bpm before treatment; cardiogenic shock, acute myocardial infarction, severe hypotension
  • Sick sinus syndrome, sino-atrial block, 3rd degree AV block, pacemaker dependence
  • Unstable or acute heart failure, unstable angina, severe hepatic insufficiency
  • Strong CYP3A4 inhibitors, and verapamil or diltiazem
  • Pregnancy and breast-feeding

Important warnings

  • In angina only symptomatic benefit; no benefit on cardiovascular outcomes
  • Use serial heart rate measurements, ECG or 24-hour monitoring before starting and when titrating
  • Not effective for arrhythmias; not recommended in atrial fibrillation
  • Bradycardia with dizziness, fatigue or hypotension may occur

Side effects

  • Most common: luminous phenomena (phosphenes, 14.5%) and bradycardia (3.3%), dose dependent
  • Common: headache, dizziness, blurred vision, 1st degree AV block, ventricular extrasystoles, atrial fibrillation, uncontrolled blood pressure
  • Very rare: 2nd and 3rd degree AV block, sick sinus syndrome

Interactions

  • QT-prolonging medicines (e.g. quinidine, sotalol, amiodarone, pimozide): concomitant use not recommended
  • Strong CYP3A4 inhibitors, verapamil and diltiazem: contraindicated; avoid grapefruit juice
  • Moderate CYP3A4 inhibitors (e.g. fluconazole) only at a starting dose of 2.5 mg twice daily; CYP3A4 inducers (e.g. rifampicin, St John's Wort) lower levels
  • Potassium-depleting diuretics: hypokalaemia plus bradycardia predisposes to severe arrhythmias

Pregnancy and breastfeeding

  • Pregnancy: contraindicated (embryotoxic and teratogenic in animals); women of childbearing potential should use contraception
  • Breast-feeding: contraindicated

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

Common questions – ask Medelix

For patients

Package leaflet, verbatim

Package leaflet for patients →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

EU – centrally authorised (all member states)

Source: European Medicines Agency (EMA), product information

Austria

  • Ivabradin AristoAristo Pharma Gmbh (Art 57) · 1 register entry
  • Ivabradin GenericonGenericon Pharma Gesellschaft M.B.H. · 1 register entry
  • Ivabradin HcsHcs Bvba · 1 register entry
  • Ivabradin RatiopharmTeva B.V · 1 register entry
  • Ivabradin SandozSandoz Gmbh · 2 register entries
  • Ivabradin StadaStada Arzneimittel Gmbh · 1 register entry
  • IvacorlanG.L. Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • IvabalanTad Pharma Gmbh · 1 register entry
  • Ivabradin1 A Pharma Gmbh, Ratiopharm Gmbh, Medical Valley Invest Ab, Heumann Pharma Gmbh & Co. Generica Kg, Amarox Pharma Gmbh, Aristo Pharma Gmbh (Art 57), Puren Pharma Gmbh & Co. Kg, Betapharm Arzneimittel Gmbh, Abz-Pharma Gmbh, Aliud Pharma Gmbh · 12 register entries
  • IvabranioAxunio Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • ArivadinALİ RAİF İLAÇ SAN. A.Ş. · 2 register entries
  • CoralanSERVIER İLAÇ VE ARAŞTIRMA A.Ş. · 2 register entries
  • CovadrinBİOFARMA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 26 more European countries
Belgium
Ivabradine Ab, Ivabradine Krka
Bulgaria
Апредонав, Биксебра, Ивабенор, Ивабрадин Майлан, Иневика, Корледин, Нормобрадин, Раеном
Croatia
Bixebra
Cyprus
Apredonav, Bivelen, Bradirem
Czechia
Bixebra, Ivabradin Teva, Raenom
Denmark
Ivabradin Krka, Ivabradin Medical Valley, Ivabradin Pharmathen, Ivabradin Teva B.V., Vadyrano
Estonia
Brediwal, Ivabradine Viatris
France
Ivabradine Alter, Ivabradine Arrow, Ivabradine Biogaran, Ivabradine Cristers, Ivabradine Eg, Ivabradine Krka, Ivabradine Sandoz, Ivabradine Teva, Ivabradine Viatris, Ivabradine Zydus
Greece
Apredonav, Bravigo, Doborel, Ivabradine Demo, Ivabradine Uni-Pharma, Vadyrano
Hungary
Bravadin, Inevica, Raenom
Iceland
Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva, Procoralan
Ireland
Ivabradine Krka, Ivabradine Rowex
Italy
Ivabradina Aurobindo, Ivabradina Doc Generici, Ivabradina Eg, Ivabradina Krka, Ivabradina Mylan Pharma, Ivabradina Sandoz, Ivabradina Teva Italia
Latvia
Apredonav, Bixebra, Brivecor, Ivabradine Viatris, Raenom
Liechtenstein
Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva, Procoralan
Lithuania
Apredonav, Bixebra, Ivabradine Actavis, Ivabradine Ingen Pharma, Ivabradine Viatris
Malta
Apredonav
Netherlands
Ivabradine Amarox, Ivabradine Aurobindo, Ivabradine Brillpharma, Ivabradine Cf, Ivabradine Chanelle Medical, Ivabradine Chemo Ibérica, Ivabradine Doc Generici, Ivabradine Glenmark, Ivabradine Sandoz, Ivabradine Synthon, Ivabradine Teva, Ivabradine Viatris, Ivabradine Xiromed, Lvabradine Glenmark
Norway
Corlentor, Ivabradine Accord, Ivabradine Anpharm, Ivabradine Zentiva, Procoralan
Poland
Bixebra, Disocor, Ivabradine Aurovitas, Ivabradine Ranbaxy, Ivabradine Viatris, Ivohart, Raenom
Portugal
Bluepharma Bluesar, Ivabradina Alter, Ivabradina Ampdr, Ivabradina Aurovitas, Ivabradina Bluepharma, Ivabradina Bluesar, Ivabradina Ciclum, Ivabradina Fantex, Ivabradina Farmoz, Ivabradina Genepharm, Ivabradina Generis, Ivabradina Krka, Ivabradina Pharmakern, Ivabradina Teva, Ivabradina Tolife, Ivabradina Viatris, Ivlan
Romania
Apredonav, Bixebra, Felocord, Ivabradină Teva, Raenom
Slovakia
Bixebra, Ivabradin Stada, Ivabradine Viatris, Ivabradín Sandoz, Ivabradín Teva Slovakia, Raenom
Slovenia
Apredonav, Bixebra
Spain
Apredonav, Ivabradina Alter, Ivabradina Aurovitas, Ivabradina Chemo Ibérica, Ivabradina Cinfa, Ivabradina Combix, Ivabradina Kern Pharma, Ivabradina Krka, Ivabradina Normon, Ivabradina Pensa, Ivabradina Stada, Ivabradina Tarbis, Ivabradina Tecnigen, Ivabradina Teva Group, Ivabradina Viatris, Ivabradina Vir
Sweden
Ivabradin Krka, Ivabradin Medical Valley

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. European Medicines Agency. Corlentor – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/corlentor-epar-product-information_en.pdf
  2. European Medicines Agency. Ivabradine Anpharm – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/ivabradine-anpharm-epar-product-information_en.pdf
  3. European Medicines Agency. Procoralan – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/procoralan-epar-product-information_en.pdf
  4. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  5. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  6. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.