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emtricitabine/tenofovir disoproxil

Truvada · ATC code J05AR03

Also known as: Emtricitabin/Tenofovirdisoproxil, Emtricitabine / Tenofovir Disoproxil · Brand names: Truvada, Emtricitabin/Tenofovir Sandoz, Emtricitabin/Tenofovirdisoproxil Stada, Emtricitabin/Tenofovirdisoproxil Tillomed, Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Ratiopharm, Emtenovo, Emtricitabin Tenofovirdisoproxil Zentiva, Emtricitabin/Tenofovirdisoproxil Abdi, Emtricitabin/Tenofovirdisoproxil Al, Emtricitabin/Tenofovirdisoproxil Amarox, Emtricitabin/Tenofovirdisoproxil Beta, Emtricitabin/Tenofovirdisoproxil Cipla, Emtricitabin/Tenofovirdisoproxil Heumann, Emtricitabin/Tenofovirdisoproxil Hormosan …

Key facts
Active substance
emtricitabine/tenofovir disoproxil (INN: emtricitabine / tenofovir disoproxil)
Drug class
Efavirenz/lamivudine/tenofovir
ATC code
J05AR03
Authorisation
centrally authorised across the EU (EMA)
Dosage forms
Truvada 200 mg/245 mg film-coated tablets
Marketing authorisation holder
Gilead Sciences Ireland UC
Information as of
2026-10-27

Key facts

Emtricitabine/tenofovir disoproxil combines two nucleoside/nucleotide reverse transcriptase inhibitors for treatment of HIV-1 infection and pre-exposure prophylaxis (PrEP).

What it is used for

  • Treatment of HIV-1 infection in adults as part of antiretroviral combination therapy
  • HIV-1 infected adolescents when NRTI resistance or toxicities preclude first-line agents
  • PrEP combined with safer sex practices in adults and adolescents at high risk

Dosing

  • Treatment and PrEP (aged 12 and older, at least 35 kg): one tablet once daily
  • Missed dose within 12 hours: take as soon as possible; vomiting within 1 hour: take another tablet
  • Treatment with CrCl 30-49 mL/min: every 48 hours; CrCl < 30 mL/min and haemodialysis: not recommended
  • PrEP not recommended with CrCl < 60 mL/min
  • No dose adjustment in the elderly or hepatic impairment

Contraindications

  • Hypersensitivity to the active substances or any excipient
  • PrEP in individuals with unknown or positive HIV-1 status

Important warnings

  • PrEP only in confirmed HIV-negative individuals, re-tested frequently, as resistance can emerge
  • PrEP only as part of an overall prevention strategy, e.g. condom use and STI testing
  • Renal impairment up to renal failure and Fanconi syndrome; creatinine clearance before starting and regularly
  • Bone abnormalities such as osteomalacia and reduced bone mineral density
  • HBV co-infection: severe exacerbations of hepatitis possible after discontinuation

Side effects

  • HIV treatment: most frequently nausea and diarrhoea
  • PrEP: headache most frequent; no new adverse reactions
  • Renal effects and bone abnormalities with tenofovir disoproxil

Interactions

  • Not with other products containing emtricitabine, tenofovir disoproxil, tenofovir alafenamide or cytidine analogues such as lamivudine
  • Not with adefovir dipivoxil
  • Low potential for CYP450-mediated interactions

Pregnancy and breastfeeding

  • A large amount of data shows no malformations; use in pregnancy may be considered if necessary
  • Not during breast-feeding; women living with HIV are advised not to breast-feed

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Package leaflet, verbatim

Package leaflet for patients →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

EU – centrally authorised (all member states)

Source: European Medicines Agency (EMA), product information

Austria

  • Emtricitabin/Tenofovir SandozSandoz Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil StadaStada Arzneimittel Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil TillomedTillomed Pharma Gmbh · 1 register entry
  • Emtricitabine/Tenofovir Disoproxil AccordpharmaAccord Healthcare B.V. · 1 register entry
  • Emtricitabine/Tenofovir Disoproxil RatiopharmTeva B.V · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • EmtenovoTad Pharma Gmbh · 1 register entry
  • Emtricitabin Tenofovirdisoproxil ZentivaZentiva Pharma Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil AbdiAbdi Farma Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil AlAliud Pharma Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil AmaroxAmarox Pharma Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil BetaBetapharm Arzneimittel Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil CiplaCipla Europe Nv · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil HeumannHeumann Pharma Gmbh & Co. Generica Kg · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil HormosanHormosan Pharma Gmbh · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil PurenPuren Pharma Gmbh & Co. Kg · 1 register entry
  • Emtricitabin/Tenofovirdisoproxil RatiopharmRatiopharm Gmbh · 1 register entry
  • OremtenOresund Pharma Aps · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • HiventİLKO İLAÇ SAN.VE TİC. A.Ş. · 2 register entries
  • PernoiSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • SidatriaSANOFİ İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • TruventHUMANİS SAĞLIK A.Ş. · 2 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 23 more European countries
Belgium
Emtricitabin/Tenofovir Disoproxil Ab
Croatia
Emtricitabin/Tenofovirdizoproksil Pliva
Cyprus
Exatron
Denmark
Emtricitabin/Tenofovirdisoproxil Tillomed, Emtricitabine/Tenofovir Disoproxil "sandoz", Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Glenmark, Emtricitabine/Tenofovir Disoproxil Stada, Emtricitabine/Tenofovir Disoproxil Teva, Oremten
Estonia
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Teva, Emtricitabine/Tenofovir Zentiva
Finland
Emtricitabine / Tenofovir Disoproxil Stada, Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Tillomed
France
Emtricitabine/ Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Accord, Emtricitabine/Tenofovir Disoproxil Arrow, Emtricitabine/Tenofovir Disoproxil Biogaran, Emtricitabine/Tenofovir Disoproxil Cipla, Emtricitabine/Tenofovir Disoproxil Eg, Emtricitabine/Tenofovir Disoproxil Evolugen, Emtricitabine/Tenofovir Disoproxil Teva, Emtricitabine/Tenofovir Disoproxil Zentiva Lab, Emtricitabine/Tenofovir Disoproxil Zydus
Greece
Argiodin, Emtricitabin/Tenofovir Disoproxil Accord, Valdevon
Hungary
Dunotrisin, Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir-Disoproxil Teva, Tabinera
Iceland
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Krka, Emtricitabine/Tenofovir Disoproxil Mylan, Emtricitabine/Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Zentiva, Truvada
Ireland
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Clonmel, Emtricitabine/Tenofovir Disoproxil Teva, Emtricitabine/Tenofovir Disoproxil Tillomed
Italy
Emtricitabina E Tenofovir Disoproxil Aequilibrium Pharma, Emtricitabina E Tenofovir Disoproxil Aurobindo, Emtricitabina E Tenofovir Disoproxil Doc Generici, Emtricitabina E Tenofovir Disoproxil Teva
Latvia
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Teva, Emtricitabine/Tenofovir Disoproxil Unifarma
Liechtenstein
Emtricitabine/Tenofovir Disoproxil Mylan, Emtricitabine/Tenofovir Disoproxil Zentiva, Truvada
Lithuania
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Sandoz
Netherlands
Emtricitabine Tenofovir Disoproxyl Fumarate Aurobindo, Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovirdisoproxil Accord, Emtricitabine/Tenofovirdisoproxil Amarox, Emtricitabine/Tenofovirdisoproxil Doc Generici, Emtricitabine/Tenofovirdisoproxil Glenmark, Emtricitabine/Tenofovirdisoproxil Sandoz, Emtricitabine/Tenofovirdisoproxil Teva, Emtricitabine/Tenofovirdisoproxil Tillomed, Valdevon
Norway
Emtricitabin/Tenofovirdisoproxil Tillomed, Emtricitabine/ Tenofovir Disoproxil Cipla, Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Krka, Emtricitabine/Tenofovir Disoproxil Mylan, Emtricitabine/Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Zentiva, Truvada
Poland
Emtricitabine + Tenofovir Disoproxil Aurovitas, Emtricitabine + Tenofovir Disoproxil Tillomed
Portugal
Emtricitabina + Tenofovir Accord, Emtricitabina + Tenofovir Disoproxil, Emtricitabina + Tenofovir Farmoz, Emtricitabina + Tenofovir Generis, Emtricitabina + Tenofovir Teva, Emtricitabina + Tenofovir Zentiva
Romania
Emtricitabină/Tenofovir Disoproxil Stada, Emtricitabină/Tenofovir Disoproxil Teva, Emtricitabină/Tenofovir Disoproxil Tillomed
Slovenia
Emtricitabin/Dizoproksiltenofovirat Teva
Spain
Emtricitabina/Tenofovir Disoproxilo Aurovitas, Emtricitabina/Tenofovir Disoproxilo Glenmark, Emtricitabina/Tenofovir Disoproxilo Macleods, Emtricitabina/Tenofovir Disoproxilo Tillomed, Emtricitabine/Tenofovir Disoproxil Teva
Sweden
Emtricitabine/Tenofovir Disoproxil Accordpharma, Emtricitabine/Tenofovir Disoproxil Glenmark, Emtricitabine/Tenofovir Disoproxil Sandoz, Emtricitabine/Tenofovir Disoproxil Stada, Emtricitabine/Tenofovir Disoproxil Teva, Emtricitabine/Tenofovir Disoproxil Tillomed, Oremten

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. European Medicines Agency. Truvada – EPAR, Product Information (OF THE TEXT Detailed information on this medicinal product i). 2026-10-27. https://www.ema.europa.eu/en/documents/product-information/truvada-epar-product-information_en.pdf
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC J05AR.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.