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Diltiazem

Diltiazem Ratiopharm, Diltiazem Retard G.L, Diltiazem Retard Genericon, Diltiazem Retard Ratiopharm · ATC code C08DB01

Brand names: Diltiazem Ratiopharm, Diltiazem Retard G.L, Diltiazem Retard Genericon, Diltiazem Retard Ratiopharm, Diltiazem Abz, Diltiazem Ethypharm, Dilzem Retard, Altizem SR, Dilkor SR, Diltizem, Kartiazem, Pectazem, Progor, Tiacard, Cardizem CD …

Key facts
Active substance
Diltiazem
ATC code
C08DB01
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Diltiazem is a calcium channel blocker. Per the US prescribing information (tablets), it is used for chronic stable angina and angina due to coronary artery spasm.

What it is used for

  • Chronic stable angina
  • Angina due to coronary artery spasm

Dosing

  • Start with 30 mg four times daily, before meals and at bedtime.
  • Increase gradually at 1- to 2-day intervals, in three or four divided doses, until optimum response.
  • Average optimum range: 180 mg/day to 360 mg/day.
  • No data in renal or hepatic impairment; titrate with particular caution.
  • Do not split tablets; they may be swallowed whole, crushed or chewed.

Contraindications

  • Sick sinus syndrome or second- or third-degree AV block without a functioning ventricular pacemaker
  • Hypotension (less than 90 mm Hg systolic)
  • Acute myocardial infarction with pulmonary congestion on x-ray
  • Hypersensitivity to the drug

Important warnings

  • Cardiac conduction: bradycardia and second- or third-degree AV block possible; additive effects with beta-blockers or digitalis
  • Caution in impaired ventricular function (congestive heart failure)
  • Symptomatic hypotension may occur
  • Rare acute hepatic injury, reversible on discontinuation
  • Skin reactions up to erythema multiforme or exfoliative dermatitis; discontinue if persistent

Side effects

  • Most common: edema (2.4%), headache (2.1%), nausea (1.9%)
  • Dizziness (1.5%), rash (1.3%), asthenia (1.2%)
  • Infrequent: AV block, bradycardia, hypotension, congestive heart failure, syncope

Interactions

  • Beta-blockers and digitalis: additive conduction effects; monitor digoxin levels
  • CYP3A4-metabolized statins: increased risk of myopathy and rhabdomyolysis
  • Avoid rifampin and other CYP3A4 inducers when possible; cimetidine raises diltiazem levels
  • Cyclosporine: monitor concentrations

Pregnancy and breastfeeding

  • No well-controlled studies; use in pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Diltiazem is excreted in human milk; if use is essential, an alternative method of infant feeding should be used.

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • Diltiazem RatiopharmTeva B.V · 1 register entry
  • Diltiazem Retard G.LG.L. Pharma Gmbh · 1 register entry
  • Diltiazem Retard GenericonGenericon Pharma Gesellschaft M.B.H. · 1 register entry
  • Diltiazem Retard RatiopharmTeva B.V · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Diltiazem AbzAbz-Pharma Gmbh · 1 register entry
  • Diltiazem EthypharmEthypharm · 1 register entry
  • Diltiazem RatiopharmRatiopharm Gmbh · 1 register entry
  • Dilzem RetardPfizer Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • Altizem SRNOBEL İLAÇ SAN. VE TİC. A.Ş. · 6 register entries
  • Dilkor SRULKAR KİMYA SAN. VE TİC. A.Ş. · 8 register entries
  • DiltizemGENSENTA İLAÇ SANAYİ VE TİC. A.Ş. · 7 register entries
  • KartiazemSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • PectazemMENARİNİ SAĞLIK VE İLAÇ SAN. TİC. A.Ş. · 1 register entry
  • ProgorGALEPHARMA İLAÇ SAN. VE TİC. A.Ş. · 4 register entries
  • TiacardVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • Cardizem CDBausch Health US LLC · 1 register entry
  • Cardizem LABausch Health US LLC · 1 register entry
  • Cartia XT3 register entries
  • Tiadylt ERZydus Pharmaceuticals (USA) Inc., Zydus Lifesciences Limited · 3 register entries
  • Tiazac Extended ReleaseBausch Health US, LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 24 more European countries
Belgium
Diltiazem Retard Eg, Progor, Tildiem
Bulgaria
Алдизем, Дилтиазем Софарма
Croatia
Aldizem
Cyprus
Denazox, Diazem
Czechia
Diacordin Retard
Denmark
Cardil
Estonia
Diltiazem Lannacher
Finland
Dilzem
France
Bi Tildiem L.P., Chlorhydrate De Diltiazem Viatris, Diazem L.P., Diltiazem Biogaran, Diltiazem L.P. Biogaran, Diltiazem Lp Arrow, Diltiazem Lp Bgr, Diltiazem Lp Sandoz, Diltiazem Lp Teva Sante, Diltiazem Lp Viatris, Diltiazem Lp Zentiva Lab, Diltiazem Teva, Diltiazem Viatris, Mono Tildiem Lp, Tildiem
Greece
Dipen, Elvesil, Mavitalon, Tildiem
Hungary
Blocalcin
Iceland
Cardil
Ireland
Adizem-Sr, Adizem-Xl
Italy
Altiazem, Diladel, Diltiazem Doc Generici, Diltiazem Eg, Diltiazem Mylan Generics Italia, Diltiazem Sandoz, Dilzene, Tildiem
Latvia
Diltiazem Lannacher
Lithuania
Diltiazem Lannacher
Luxembourg
Diltiazem Retard Eg, Progor, Tildiem
Malta
Denazox, Diazem
Netherlands
Diltiazem Aurobindo, Diltiazem Hcl Retard Mylan, Diltiazem Hcl Retard Teva, Diltiazem Hcl Sandoz, Diltiazemhydrochloride Aurobindo
Portugal
Anatop, Anotrit, Diltiazem Apilif, Diltiazem Farmoz, Diltiazem Ratiopharm, Herbesser
Romania
Diltiazem Arena, Diltiazem Eipico, Diltiazem Lph Labormed, Diltiazem Sr Rompharm
Slovakia
Diacordin Retard
Slovenia
Aldizem
Spain
Angiodrox, Carreldon Retard, Cronodine, Diltiazem Alter, Diltiazem Aristo, Diltiazem Dermogen, Diltiazem Farmalider, Diltiazem Pensa, Diltiazem Retard Stada, Diltiazem Sandoz, Diltiazem Stada, Diltiwas Retard, Dinisor Retard, Lacerol, Masdil, Trumsal, Uni-Masdil

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. U.S. Food and Drug Administration. Diltiazem hydrochloride (Viona Pharmaceuticals Inc) – Prescribing Information, 2025-05-05. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=43cffe12-304a-4e15-9512-94f812188f1a
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.