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Digoxin

Digoxin-Assos, Digoxine-Assos, Digoxine Nativelle · ATC code C01AA05

Also known as: Digoksin · Brand names: Lanicor, Lenoxin®, Digoxin-Assos, Digoxine-Assos, Digoxine Nativelle, Lanoxin

Key facts
Active substance
Digoxin
Drug class
Cardiac glycoside
ATC code
C01AA05
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Digoxin is a cardiac glycoside. Per the US prescribing information (Lanoxin), it is used for mild to moderate heart failure and for rate control in chronic atrial fibrillation.

What it is used for

  • Mild to moderate heart failure in adults, where possible with a diuretic and an ACE inhibitor
  • Heart failure in pediatric patients (increases myocardial contractility)
  • Control of ventricular response rate in adults with chronic atrial fibrillation

Dosing

  • Dose individualised by body weight, age, renal function and concomitant drugs; toxic levels are only slightly above therapeutic levels
  • Optional loading: half the total loading dose first, then ¼ every 6-8 hours twice
  • Total oral loading dose in adults and children over 10 years: 10-15 mcg/kg
  • Starting maintenance in adults and children over 10 years with normal renal function: 3.4-5.1 mcg/kg/day once daily
  • Maintenance by lean body weight and renal function (table in the full text); pediatric doses in the full text
  • Consider interrupting or reducing the dose before electrical cardioversion

Contraindications

  • Ventricular fibrillation
  • Known hypersensitivity to digoxin or other digitalis preparations

Important warnings

  • Ventricular fibrillation in Wolff-Parkinson-White syndrome with atrial fibrillation
  • Severe sinus bradycardia, sinoatrial block and AV block may occur
  • Digoxin toxicity; narrow therapeutic index

Side effects

  • Adverse reactions are dose-dependent and mostly occur above therapeutic doses
  • Cardiac arrhythmias
  • Digoxin toxicity: hospitalization for suspected toxicity in the DIG trial 2% (placebo 0.9%)

Interactions

  • Narrow therapeutic index: monitor levels and toxicity when starting, adjusting or stopping interacting drugs
  • Digoxin is a P-glycoprotein substrate; P-gp inducers and inhibitors alter its pharmacokinetics
  • Drugs increasing digoxin concentrations by more than 50% are listed in a table in the full text

Pregnancy and breastfeeding

  • Decades of experience in pregnancy have not identified a drug-associated risk of major birth defects or miscarriage

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

Common questions – ask Medelix

For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Germany

  • LanicorTeofarma S.R.L. · 2 register entries
  • Lenoxin®Aspen Pharma Trading Limited · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • Digoxin-AssosASSOS İLAÇ KİMYA GIDA ÜRÜNLERİ ÜRETİM VE TİC. A.Ş. · 2 register entries
  • Digoxine-AssosASSOS İLAÇ KİMYA GIDA ÜRÜNLERİ ÜRETİM VE TİC. A.Ş. · 1 register entry
  • Digoxine NativelleADİLNA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • LanoxinCovis Pharma US, Inc, Advanz Pharma (US) Corp. · 3 register entries

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 23 more European countries
Belgium
Lanoxin
Bulgaria
Дигоксин Софарма
Czechia
Digoxin Eneo, Digoxin Léčiva
Denmark
Digoxin Dak, Digoxin Sad
Estonia
Digoxin Eneo, Digoxin Grindeks, Digoxin Orifarm
Finland
Digoxin Orion Mite, Orion
France
Digoxine Adultes Nativelle, Digoxine Arrow, Digoxine Nativelle, Hemigoxine Nativelle
Greece
Digoxin Anfarm, Digoxin Juvisé
Hungary
Digoxin Eneo, Digoxin Richter, Digoxin Sopharma
Ireland
Lanoxin
Italy
Lanoxin
Latvia
Digoxicor, Digoxin Grindeks
Lithuania
Digoxin Sopharma
Luxembourg
Lanoxin
Malta
Digoxin Bristol Laboratories, Digoxin Sopharma, Lanoxin
Netherlands
Lanoxin
Norway
Digoxin Orifarm
Poland
Digoxin Eneo, Digoxin Teva, Digoxin Wzf
Portugal
Lanoxin
Romania
Digoxin Eneo, Digoxin Zentiva, Digoxină Zentiva
Slovakia
Digoxin Eneo, Digoxin Léčiva, Digoxin L뿯½čiva
Spain
Digoxina Kern Pharma, Digoxina Teofarma, Lanacordin Pediátrico
Sweden
Digoxin Evolan

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

Another question about this substance?

Medelix answers clinical questions from guidelines, studies and product information – every claim with its source.

Sources

  1. U.S. Food and Drug Administration. LANOXIN (Advanz Pharma (US) Corp.) – Prescribing Information, 2024-12-05. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d91e3646-4c63-4512-ab22-db39c085c4dc
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  4. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  5. Wikidata (CC0): ATC C01AA.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.