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Clotrimazole

Candibene, Canesten, Imazol, Otomyk · ATC code G01AF02

Also known as: Clotrimazol, Klotrimazol · Brand names: Candibene, Canesten, Imazol, Otomyk, Antifungol Hexal, Antimykal, Apocanda, Canifug, Cloderm, Clotri, Clotrigalen, Clotrikad, Fungizid, Gilt, Imazol Paste …

Key facts
Active substance
Clotrimazole
ATC code
G01AF02
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Clotrimazole is an azole antifungal. Per the US label, it is used as a troche (lozenge) for local treatment and prevention of oropharyngeal candidiasis.

What it is used for

  • Local treatment of oropharyngeal candidiasis; diagnosis should be confirmed by KOH smear and/or culture
  • Prophylaxis of oropharyngeal candidiasis in patients immunocompromised by chemotherapy, radiotherapy or steroid therapy for leukemia, solid tumors or renal transplantation

Dosing

  • Given only as a lozenge slowly dissolved in the mouth
  • Treatment: one troche five times a day for fourteen consecutive days
  • Prophylaxis: one troche three times daily for the duration of chemotherapy or until steroids are reduced to maintenance levels
  • Only limited data on prolonged use; therapy should be short term if possible

Contraindications

  • Hypersensitivity to any of its components

Important warnings

  • Not indicated for systemic mycoses, including systemic candidiasis
  • No controlled data for prophylaxis in immunocompromise from other causes

Side effects

  • Abnormal liver function tests; elevated SGOT in about 15% of patients in clinical trials
  • Nausea, vomiting, unpleasant mouth sensations, pruritus

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

Common questions – ask Medelix

For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • CandibeneTeva B.V · 2 register entries
  • CanestenBayer Austria Gmbh · 5 register entries
  • ImazolLaboratoires Bailleul S.A. · 1 register entry
  • OtomykInfectopharm Arzneimittel Und Consilium Gmbh, De, Heppenheim · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Antifungol HexalHexal Ag · 2 register entries
  • AntimykalRobugen Gmbh Pharmazeutische Fabrik · 1 register entry
  • ApocandaAristo Pharma Gmbh (Art 57) · 3 register entries
  • CanestenBayer Vital Gmbh · 5 register entries
  • CanifugDr. August Wolff Gmbh & Co. Kg Arzneimittel · 2 register entries
  • ClodermDermapharm Ag · 1 register entry
  • ClotriDenk Pharma Gmbh & Co. Kg · 1 register entry
  • ClotrigalenGalenpharma Gmbh · 2 register entries
  • ClotrikadDr. Kade Pharmazeutische Fabrik Gmbh · 1 register entry
  • Clotrimazol1 A Pharma Gmbh, Aristo Pharma Gmbh (Art 57), Mibe Gmbh Arzneimittel, Aliud Pharma Gmbh · 5 register entries
  • FungizidRatiopharm Gmbh · 4 register entries
  • GiltLaves-Arzneimittel Gmbh · 2 register entries
Show all 23 brand names
  • Imazol PasteLaboratoires Bailleul S.A. · 1 register entry
  • KadefunginDr. Kade Pharmazeutische Fabrik Gmbh · 5 register entries
  • Myko CordesIchthyol-Gesellschaft Cordes, Hermanni & Co. (Gmbh & Co.) Kg · 1 register entry
  • MykofunginMibe Gmbh Arzneimittel · 2 register entries
  • Mykohaug CBetapharm Arzneimittel Gmbh · 1 register entry
  • Mykomed CremeWalter Ritter Gmbh + Co. Kg · 1 register entry
  • OnymykénSchuck Gmbh · 1 register entry
  • OtomykInfectopharm Arzneimittel Und Consilium Gmbh, De, Heppenheim · 1 register entry
  • Vagiflor MykomedWalter Ritter Gmbh + Co. Kg · 1 register entry
  • Vagisan MykoDr. August Wolff Gmbh & Co. Kg Arzneimittel · 5 register entries
  • Warimazol VagWalter Ritter Gmbh + Co. Kg · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • Gyno-CanestenBAYER TÜRK KİMYA SAN. LTD. ŞTİ. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • CLOTIC (clotrimazole) otic solutionCarwin Pharmaceutical Associates, LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 27 more European countries
Belgium
Canestene Gyn, Canestene Intim
Bulgaria
Канестен, Клотримазол
Croatia
Canesten, Canifug, Klotrimazol Pliva, Plimycol, Vagisan Myko Kombi
Cyprus
Canesten, Mycoril, Warimazol
Czechia
Candibene, Canesten, Canifug, Clotrimazol Cotylena, Clotrimazole, Cotylena, Imazol Krémpasta, Jenamazol, Lozamyk
Denmark
Canesten, Canvag, Clotic
Estonia
Canesten, Canifug, Clotrimazole Auxilia, Imazol, Klotrimasool Gsk
Finland
Canesderm, Canesten, Clotic
France
Clotrimazole Eg Labo Conseil, Mycohydralin
Greece
Canesten
Hungary
Candibene, Canesten, Imamono, Vagisan Myko Cremolum
Iceland
Canesten
Ireland
Canesten
Italy
Antimicotico Same, Candazol, Canesten, Cangil, Clotic, Clotrimazolo Doc, Clotrimazolo Eg, Clotrimazolo Farmakopea, Clozol, Ellecos, Gyno-Canesten, Lenil Antimicotico, Lenirit Micosi, Vagisil Antimicotico
Latvia
Canesten, Canifug Cremolum, Clotrimazolum Gsk, Klotrimazol Polpharma, Miclodin
Lithuania
Canesten, Canifug Cremolum, Clotrimazole Ingen Pharma, Clotrimazolum Gsk, Klotrimazolas Polpharma, Miclodin
Luxembourg
Canestene Gyn, Canestene Intim, Fungizid
Malta
Canesten, Clotrimazolum Hasco, Nalbix
Netherlands
Canesten Foot, Canesten Gyno, Canesten Skin, Clotrimazol Gyno Ace, Clotrimazol Gyno Teva, Clotrimazol Kruidvat, Clotrimazol Trekpleister, Linn
Norway
Canesten, Clotic
Poland
Canesten, Clotidal, Clotrimazolum Aflofarm, Clotrimazolum Amara, Clotrimazolum Gsk, Clotrimazolum Hasco, Clotrimazolum Medana, Clotrimazolum Promedo, Clotrimazolum Ziaja, Dromyc, Fungotac, Imazol, Pirolam Intima Vag
Portugal
Candigen, Candiset, Canesten, Clotrimazol Basi, Clotrimazol Bluepharma, Clotrimazol Farmoz, Clotrimazol Generis, Clotrimazol Labesfal, Clotrimazol Labialfarma, Clotrimazol Laphysan, Diomicete, Fungotux, Gino-Canesten, Gino-Hadazin, Hadazin, Holginec, Holpemic, Ligynax, Micolysin, Nalbix, Otasol, Tinesil, Urpux, Vilfux, Zolenov
Romania
Canesten, Clotrimazol Atb, Clotrimazol Biofarm, Clotrimazol Fiterman, Clotrimazol Hyperion, Clotrimazol Mcc, Clotrimazol Rompharm, Clotrimazol Slavia, Clotrimazol Zentiva
Slovakia
Candibene, Canesten, Canifug, Clotrimazol Al, Clotrimazole Dr. Müller Pharma, Imazol Krémpasta, Jenamazol, Lozamyk
Slovenia
Canesten, Canesten1, Canesten3, Canifug, Leotimez
Spain
Canesmed, Canespie, Canestén, Clotrimazol Laphysan, Clotrimazol Nutra Essential, Gine-Canesmed, Gine-Canestén
Sweden
Canesten, Clotic

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

Another question about this substance?

Medelix answers clinical questions from guidelines, studies and product information – every claim with its source.

Sources

  1. U.S. Food and Drug Administration. Clotrimazole (Hikma Pharmacuticals USA USA Inc.) – Prescribing Information, 2021-07-30. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0bc4b876-ddee-4f03-b44f-544348739a26
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.