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Clonazepam

Rivotril · ATC code N03AE01

Also known as: klonazepam · Brand names: Rivotril, Antelepsin, Clonazepam Aristo, Clonazepam Holsten, Clonazepam Neuraxpharm, Malontil, Rivoclon, Klonopin

Key facts
Active substance
Clonazepam
Drug class
Benzodiazepine drug
ATC code
N03AE01
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Boxed warning

  • Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation (see WARNINGSand PRECAUTIONS).
  • The use of benzodiazepines, including clonazepam tablets, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing clonazepam tablets and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction (see WARNINGS).
  • The continued use of benzodiazepines, including clonazepam tablets, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of clonazepam tablets after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue clonazepam tablets or reduce the dosage (see DOSAGE AND ADMINISTRATIONand WARNINGS).

Key facts

Clonazepam is a benzodiazepine with anticonvulsant activity. Per the US label it is used for certain seizure disorders and for panic disorder.

What it is used for

  • Seizure disorders: alone or as adjunct in Lennox-Gastaut syndrome, akinetic and myoclonic seizures
  • Absence seizures that failed to respond to succinimides
  • Panic disorder with or without agoraphobia

Dosing

  • Seizures, adults: initial dose not exceeding 1.5 mg/day in three divided doses; increase by 0.5 to 1 mg every 3 days; maximum 20 mg/day
  • Seizures, children (up to 10 years or 30 kg): start 0.01 to 0.03 mg/kg/day, not exceeding 0.05 mg/kg/day, in two or three doses; maintenance 0.1 to 0.2 mg/kg
  • Panic disorder, adults: start 0.25 mg twice daily, target 1 mg/day after 3 days; maximum 4 mg/day
  • Elderly: start at low doses and observe closely
  • Discontinue gradually (panic disorder: decrease 0.125 mg twice daily every 3 days)

Contraindications

  • History of sensitivity to benzodiazepines
  • Clinical or biochemical evidence of significant liver disease
  • Acute narrow angle glaucoma

Important warnings

  • Boxed warning: use with opioids may cause profound sedation, respiratory depression, coma and death
  • Boxed warning: abuse, misuse and addiction, which can lead to overdose or death
  • Boxed warning: physical dependence; abrupt discontinuation may cause life-threatening withdrawal reactions
  • Increased risk of suicidal thoughts or behavior (antiepileptic drugs)
  • Possible loss of effect during treatment

Side effects

  • Seizure disorders: drowsiness (approximately 50%), ataxia (approximately 30%), behavior problems (approximately 25%)
  • Others: palpitations, hair loss, rash, gastrointestinal complaints, blood count changes, respiratory depression

Interactions

  • Opioids: increased risk of respiratory depression; limit dose and duration
  • Avoid alcohol
  • Cytochrome P450 inducers (phenytoin, carbamazepine, lamotrigine, phenobarbital) decrease clonazepam levels by approximately 38%
  • Multiple anticonvulsants: increased CNS depressant effects

Pregnancy and breastfeeding

  • Use late in pregnancy can cause sedation and/or withdrawal symptoms in newborns
  • Clonazepam is excreted in human milk; sedation, poor feeding and poor weight gain reported in exposed infants

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

Patient information (US) →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • RivotrilCheplapharm Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • AntelepsinDesitin Arzneimittel Gmbh · 1 register entry
  • Clonazepam AristoAristo Pharma Gmbh (Art 57) · 1 register entry
  • Clonazepam HolstenHolsten Pharma Gmbh · 1 register entry
  • Clonazepam NeuraxpharmNeuraxpharm Arzneimittel Gmbh · 1 register entry
  • RivotrilCheplapharm Arzneimittel Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • MalontilHÜSNÜ ARSAN İLAÇLARI A.Ş. · 2 register entries
  • RivoclonSABA İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
  • RivotrilDEVA HOLDİNG A.Ş. · 2 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • KlonopinH2-Pharma, LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 25 more European countries
Belgium
Rivotril
Bulgaria
Клоназепам Tzf, Клонакса, Клонарекс, Клонатрон
Croatia
Elunari, Rivotril
Cyprus
Aklonil, Clonazepam Remedica, Clonotril
Czechia
Rivotril
Denmark
Clonazepam G.L. Pharma, Clonazepam Holsten, Iqtopam, Rivotril
Estonia
Clonazepam Sanoswiss, Rivotril
Finland
Iqtopam, Rivatril
France
Rivotril
Hungary
Clonazepam Tarchomin, Rivotril
Iceland
Iqtopam, Rivotril
Ireland
Clonazepam Rosemont, Rivotril
Italy
Clonazepam Eg, Rivotril
Latvia
Clonazepam Sanoswiss, Clonazepam Tzf
Lithuania
Clonazepam Eletis, Clonazepam Polta, Clonazepam Sanoswiss, Clonazepam Tc, Clonazepam Tzf
Luxembourg
Rivotril
Malta
Clonazepamum Tzf, Clonotril
Netherlands
Clonazepam Double-E Pharma, Clonazepam Tiofarma, Clonazepam Tzf, Rivotril
Norway
Iqtopam, Rivotril
Poland
Clonazepamum Tzf, Klonafen
Portugal
Clonazepam Aristo, Clonazepam Bluepharma, Clonazepam Wise, Rivotril, Zepacla
Romania
Clonazepam G.L. Pharma, Clonotril, Rivotril
Slovenia
Rivotril
Spain
Clonazepam Biomed, Clonazepam Neuraxpharm, Clonazepam Tzf, Rivotril
Sweden
Clonazepam /, Clonazepam Holsten, Iktorivil

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

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Sources

  1. U.S. Food and Drug Administration. Clonazepam (Advagen Pharma Ltd) – Prescribing Information, 2026-06-25. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=30d674f9-f1b3-4c2d-a8e9-3bc8e476f1ec
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC N03AE.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.