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Carvedilol

Carvedilol, Dilatrend · ATC code C07AG02

Also known as: Karvedilol · Brand names: Dilatrend, Carve Tad, Carvedi, Arlec, Calbicor, Carvexal, Coronis, Delotran, Kinetra, Velzapin, Coreg, Coreg CR

Key facts
Active substance
Carvedilol
Drug class
Beta blocker
ATC code
C07AG02
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Carvedilol is a beta-blocker with additional alpha-1-blocking activity used for chronic heart failure, left ventricular dysfunction after myocardial infarction and hypertension.

What it is used for

  • Mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin, usually added to diuretics, ACE inhibitors and digitalis
  • Left ventricular dysfunction (ejection fraction ≤ 40%) in clinically stable patients after myocardial infarction
  • Essential hypertension, alone or in combination

Dosing

  • Taken with food to reduce orthostatic effects; dosage individualized
  • Heart failure: start 3.125 mg twice daily for 2 weeks, then 6.25, 12.5 and 25 mg twice daily over intervals of at least 2 weeks
  • Heart failure: maximum 50 mg twice daily in patients over 85 kg with mild-to-moderate heart failure
  • After myocardial infarction: start 6.25 mg twice daily, increase after 3 to 10 days to 12.5 mg, target 25 mg twice daily
  • Hypertension: start 6.25 mg twice daily, increased every 7 to 14 days as needed; total daily dose not above 50 mg
  • Dose reduced if heart rate falls below 55 beats per minute

Contraindications

  • Bronchial asthma or related bronchospastic conditions
  • Second- or third-degree AV block, sick sinus syndrome, severe bradycardia (without a permanent pacemaker)
  • Cardiogenic shock or decompensated heart failure requiring intravenous inotropes
  • Severe hepatic impairment
  • History of serious hypersensitivity to carvedilol

Important warnings

  • No abrupt discontinuation in coronary artery disease: risk of worsening angina, myocardial infarction and ventricular arrhythmias; taper over 1 to 2 weeks when possible
  • Bradycardia; dose reduced if pulse falls below 55 beats per minute
  • Hypotension and dizziness, particularly at initiation and dose increases
  • Fluid retention or worsening heart failure may occur during up-titration

Side effects

  • Dizziness, lightheadedness and rarely syncope after initiation or dose increases
  • Bradycardia and hypotension
  • Fluid retention

Interactions

  • Potent CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine, propafenone) may increase blood levels
  • Catecholamine-depleting drugs (e.g. reserpine, MAO inhibitors): observe for hypotension and severe bradycardia
  • Diuretics: additive effects and exaggerated orthostatic component

Pregnancy and breastfeeding

  • Data insufficient; beta-blockers in the third trimester may increase the risk of hypotension, bradycardia, hypoglycemia and respiratory depression in the neonate

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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Patient information (US)

Patient information (US) →

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • Carvedilol1a Pharma Gmbh, Teva B.V, Krka, D.D., Novo Mesto, Genericon Pharma Gesellschaft M.B.H., +pharma Arzneimittel Gmbh, Sandoz Gmbh, Hexal Pharma Gmbh, Stada Arzneimittel Gmbh · 8 register entries
  • DilatrendCheplapharm Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Carve TadTad Pharma Gmbh · 1 register entry
  • CarvediDenk Pharma Gmbh & Co. Kg · 1 register entry
  • Carvedilol1 A Pharma Gmbh, Aaa-Pharma Gmbh, Ratiopharm Gmbh, Puren Pharma Gmbh & Co. Kg, Hexal Ag, Stadapharm Gmbh, Dexcel Pharma Gmbh, Teva Gmbh, Abz-Pharma Gmbh, Aliud Pharma Gmbh · 10 register entries
  • DilatrendCheplapharm Arzneimittel Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • ArlecALİ RAİF İLAÇ SAN. A.Ş. · 4 register entries
  • CalbicorSANTA FARMA İLAÇ SAN. A.Ş. · 6 register entries
  • CarvexalSANDOZ İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
  • CoronisBİLİM İLAÇ SAN. VE TİC. A.Ş. · 5 register entries
  • DelotranSABA İLAÇ SAN. VE TİC. A.Ş. · 4 register entries
  • DilatrendDEVA HOLDİNG A.Ş. · 4 register entries
  • KinetraSANOVEL İLAÇ SAN. VE TİC. A.Ş. · 5 register entries
  • VelzapinRECORDATİ İLAÇ SAN. VE TİC. A.Ş. · 2 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

USA

  • CoregWaylis Therapeutics LLC · 1 register entry
  • Coreg CRWaylis Therapeutics LLC · 1 register entry

Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28

Brand names in 27 more European countries
Belgium
Carvedilol Eg, Carvedilol Sandoz, Carvedilol Teva, Kredex
Bulgaria
Дилатренд, Карведил, Карведилол Софарма, Карвилекс, Кориол, Талитон
Croatia
Carvelol, Carvetrend, Coryol
Cyprus
Avernol, Bicol, Carvidex
Czechia
Atram, Coryol, Dilatrend
Denmark
Carvedilol Aurobindo, Carvedilol Hexal, Carvedilol Krka, Carvedilol Pcd, Carvedilol Teva
Estonia
Carvedilol Hexal
Finland
Cardiol, Carvedilol Hexal, Carvedilol Orion, Carvedilol Stada, Carveratio
France
Carvedilol Arrow, Carvedilol Biogaran, Carvedilol Eg, Carvedilol Teva, Carvedilol Viatris, Kredex
Greece
Carvedilen, Carvedilol Mylan, Carvepen, Dilatrend, Ervidol
Hungary
Carvedilol Hexal, Carvol, Coryol, Dilatrend, Talliton
Iceland
Carvedilol Stada
Ireland
Carvedilol Krka, Eucardic
Italy
Acarden, Caravel, Carvedilolo Almus, Carvedilolo Aurobindo, Carvedilolo Doc Generici, Carvedilolo Eg, Carvedilolo Hexal, Carvedilolo Mylan Generics, Carvedilolo Pensa, Carvedilolo Ratiopharm, Carvedilolo Sandoz, Carvedilolo Tecnigen, Carvedilolo Teva, Carvedilolo Zentiva, Carvipress, Colver, Curcix, Dilatrend, Omeria
Latvia
Carvedilol Hexal, Karvidil
Lithuania
Carvedilolhexal, Coryol
Luxembourg
Carvedilol Eg, Kredex
Malta
Carvedilol Aurobindo Pharma (Malta), Carvedilol Helcor, Carvedilol Normon
Netherlands
Carvedilol Aurobindo, Carvedilol Sandoz, Carvedilol Teva, Carvedilol Viatris
Norway
Carvedilol Aurobindo, Carvedilol Hexal
Poland
Atram, Avedol, Carvedilol Ratiopharm, Carvedilol Symphar, Carvetrend, Coryol, Dilatrend, Vivacor
Portugal
Carvedilol Aurovitas, Carvedilol Azevedos, Carvedilol Ciclum, Carvedilol Coronat, Carvedilol Farmoz, Carvedilol Generis, Carvedilol Gp, Carvedilol Jaba, Carvedilol Krka, Carvedilol Labesfal, Carvedilol Mylan, Carvedilol Ratiopharm, Carvedilol Sandoz, Carvedilol Teva, Carvedilol Viatris, Carvedilol Vitória, Dilbloc
Romania
Carvedilol, Coryol, Gladycor, Talliton
Slovakia
Carvedigamma, Carvedilol Teva, Coryol, Talliton
Slovenia
Coryol, Dilatrend
Spain
Carvedilol Almus, Carvedilol Alter, Carvedilol Aurovitas, Carvedilol Cinfa, Carvedilol Cinfamed, Carvedilol Kern Pharma, Carvedilol Krka, Carvedilol Normon, Carvedilol Sandoz, Carvedilol Tecnigen, Carvedilol Teva-Ratiopharm, Coropres, Normotride
Sweden
Carvedilol Aurobindo, Carvedilol Generics [uk], Carvedilol Hexal, Carveratio, Carvsanna, Karvedilol Viatris

EMA – Article 57 product data (EU/EEA), 2026-10-28

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Sources

  1. U.S. Food and Drug Administration. Carvedilol (Glenmark Pharmaceuticals Inc., USA) – Prescribing Information, 2025-10-27. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c4a21f67-7812-4634-beba-f8e85c63c5f2
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
  6. Wikidata (CC0): ATC C07AG.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.