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brinzolamide/timolol

Azarga · ATC code S01ED51

Also known as: Brinzolamid/Timolol, Brinzolamide / Timolol · Brand names: Azarga, Brinzotim-Vision Sine, Blizomit, Brinzloamid/Timolol Micro Labs, Brinzolamid/Timolol Al, Brinzolamid/Timolol Aliud Pharma Gmbh, Brinzolamid/Timolol Axiromed, Brinzolamid/Timolol Heumann, Brinzolamid/Timolol Zentiva, Arudor %, Azarcom, Bematorin-T, Bimapress Duo, Bimasopt, Brimo-Tim …

Key facts
Active substance
brinzolamide/timolol (INN: brinzolamide / timolol)
ATC code
S01ED51
Authorisation
centrally authorised across the EU (EMA)
Dosage forms
AZARGA 10 mg/ml + 5 mg/ml eye drops, suspension
Marketing authorisation holder
Novartis Europharm Limited
Information as of
2026-10-28

Key facts

Brinzolamide/timolol (Azarga) is an eye drop combining a carbonic anhydrase inhibitor and a beta-blocker, used to lower intraocular pressure in open-angle glaucoma or ocular hypertension.

What it is used for

  • Decrease of intraocular pressure in adults with open-angle glaucoma or ocular hypertension for whom monotherapy provides insufficient pressure reduction.

Dosing

  • Adults, including the elderly: one drop in the affected eye(s) twice daily; the dose should not exceed this.
  • Shake the bottle well before use; nasolacrimal occlusion or closing the eyelids reduces systemic absorption.
  • If several eye medicines are used, they should be given at least 5 minutes apart; eye ointments last.
  • When switching from another antiglaucoma medicine, stop it and start Azarga the following day.
  • No adjustment in hepatic impairment or mild to moderate renal impairment; contraindicated in severe renal impairment (creatinine clearance <30 ml/min); caution in severe hepatic impairment.

Contraindications

  • Hypersensitivity to the active substances, other beta-blockers or sulphonamides.
  • Reactive airway disease including bronchial asthma or a history of it, or severe chronic obstructive pulmonary disease.
  • Sinus bradycardia, sick sinus syndrome, sino-atrial block, second or third degree AV block not controlled with a pacemaker; overt cardiac failure, cardiogenic shock.
  • Severe allergic rhinitis, hyperchloraemic acidosis, severe renal impairment.

Important warnings

  • Both substances are absorbed systemically; cardiovascular, pulmonary and other beta-blocker adverse reactions may occur.
  • Sulphonamide-type hypersensitivity reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis can occur; stop immediately at signs of serious reactions.
  • Caution in cardiovascular disease, hypotension, first degree heart block and mild/moderate COPD.
  • Beta-blockers may mask signs of hypoglycaemia; caution in labile diabetes or spontaneous hypoglycaemia.
  • The preservative benzalkonium chloride may cause punctate or toxic ulcerative keratopathy.

Side effects

  • Most common: blurred vision, eye irritation and eye pain (approximately 2% to 7% of patients).
  • Common: punctate keratitis, dysgeusia, heart rate decreased.
  • Not known (individual components): anaphylaxis, cardiac failure, cerebrovascular events, worsening of myasthenia gravis, depression.

Interactions

  • Concomitant oral carbonic anhydrase inhibitors are not recommended (additive effects).
  • CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir) may inhibit brinzolamide metabolism; caution advised.
  • Additive hypotension and/or marked bradycardia possible with oral calcium channel blockers, beta-blockers, antiarrhythmics (including amiodarone), digitalis glycosides, parasympathomimetics and guanethidine.
  • Beta-blockers can decrease the response to adrenaline used for anaphylaxis.

Pregnancy and breastfeeding

  • Should not be used during pregnancy unless clearly necessary; if used until delivery, the neonate should be monitored during the first days of life.

Summary of the official product information, written with AI on 2026-10-29. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

Common questions – ask Medelix

For patients

Package leaflet, verbatim

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

EU – centrally authorised (all member states)

  • AzargaNovartis Europharm Limited · EMEA/H/C/000960

Source: European Medicines Agency (EMA), product information

Austria

  • Brinzotim-Vision SineOmnivision Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Germany

  • BlizomitNtc Srl · 1 register entry
  • Brinzloamid/Timolol Micro LabsMicro Labs Gmbh · 1 register entry
  • Brinzolamid/Timolol AlAliud Pharma Gmbh · 1 register entry
  • Brinzolamid/Timolol Aliud Pharma GmbhAliud Pharma Gmbh · 1 register entry
  • Brinzolamid/Timolol AxiromedMedical Valley Invest Ab · 1 register entry
  • Brinzolamid/Timolol HeumannHeumann Pharma Gmbh & Co. Generica Kg · 1 register entry
  • Brinzolamid/Timolol ZentivaZentiva Pharma Gmbh · 1 register entry

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-29

Turkey

  • Arudor %GENVEON İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • AzarcomVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • AzargaNOVARTİS SAĞLIK GIDA VE TARIM ÜRÜNLERİ SAN. VE TİC. A.Ş. · 1 register entry
  • Bematorin-TDEVA HOLDİNG A.Ş. · 1 register entry
  • Bimapress DuoROMPHARM İLAÇ SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • BimasoptWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Brimo-TimVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Britil-TWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Combigan %ABBVİE TIBBİ İLAÇLAR SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • DorzoltoSABA İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Dorzotim Goz DamlasiTEKA TEKNİK CİHAZLAR SAN.VE TİC. A.Ş. · 1 register entry
  • Drasoter-TDEVA HOLDİNG A.Ş. · 1 register entry
Show all 27 brand names
  • Duoprost Göz DamlasiROMPHARM İLAÇ SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • Duosopt FreeVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • DuotravNOVARTİS SAĞLIK GIDA VE TARIM ÜRÜNLERİ SAN. VE TİC. A.Ş. · 1 register entry
  • Ganfort %ABBVİE TIBBİ İLAÇLAR SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • LatamedWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • LaticomVEM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Latrost-TDEVA HOLDİNG A.Ş. · 1 register entry
  • OftomixBİLİM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Rimosopt Göz DamlasiWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • TentritWORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • TomecABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. · 1 register entry
  • Travapress DuoROMPHARM İLAÇ SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • XalacomVİATRİS İLAÇLARI LİMİTED ŞİRKETİ · 1 register entry
  • XolatimDEVA HOLDİNG A.Ş. · 1 register entry
  • Zomranip-TDEVA HOLDİNG A.Ş. · 1 register entry

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 17 more European countries
Bulgaria
Бритосопт
Czechia
Aicybet, Brinzolamid/Timolol Olikla
Denmark
Brinzolamid/Timolol Medical Valley, Brinzolamide/Timolol Zentiva
Estonia
Brinzolamide/Timolol Accord
France
Blizomit, Brinzolamide / Timolol Biogaran, Brinzolamide/Timolol Eg, Brinzolamide/Timolol Viatris, Brinzolamide/Timolol Zentiva
Greece
Blizomit
Iceland
Azarga, Brinzolamide/Timolol Stada
Italy
Aicybet, Blizomit, Brintidox, Brinzolamide E Timololo Accord, Brinzolamide E Timololo Eg, Brinzolamide E Timololo Mylan, Brinzolamide E Timololo Zentiva
Latvia
Brinzolamide/Timolol Accord, Brinzolamide/Timolol Zentiva
Liechtenstein
Azarga
Lithuania
Brinzolamide/Timolol Accord
Netherlands
Aicybet, Blizomit, Brinzolamide/Timolol Accord, Brinzolamide/Timolol Blumont, Brinzolamide/Timolol Cf, Brinzolamide/Timolol Viatris, Brinzolamide/Timolol Xiromed
Norway
Azarga, Brinzolamid/Timolol Medical Valley, Brinzolamide/Timolol Zentiva, Zoltim
Portugal
Blizomit
Slovakia
Brinzolamid/Timolol Olikla
Spain
Aicybet, Blizomit
Sweden
Brintidox, Brinzolamid/Timolol Medical Valley, Brinzolamide/Timolol Accord, Brinzolamide/Timolol Azad, Brinzolamide/Timolol Stada, Brinzolamide/Timolol Zentiva, Zoltim

EMA – Article 57 product data (EU/EEA), 2026-10-29

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

Another question about this substance?

Medelix answers clinical questions from guidelines, studies and product information – every claim with its source.

Sources

  1. European Medicines Agency. Azarga – EPAR, Product Information. 2026-10-28. https://www.ema.europa.eu/en/documents/product-information/azarga-epar-product-information_en.pdf
  2. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-29. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85

Editorial: Medelix editorial team · last updated 2026-10-28 · How these pages are made · Report an error

Source: European Medicines Agency (EMA), product information. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.