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Amantadine

Pk-Merz-Schoeller · ATC code N04BB01

Also known as: Amantadin · Brand names: Pk-Merz-Schoeller, Amantadin Ratiopharm, Amantadin Stada, Pk-Merz, Neomidantan

Key facts
Active substance
Amantadine
Drug class
Dopaminergic
ATC code
N04BB01
Authorisation
authorised nationally; no central EU authorisation
Information as of
2026-10-27

Key facts

Amantadine is an antiviral and dopaminergic agent. Per the US label, it is used for prophylaxis and treatment of influenza A and for parkinsonism and drug-induced extrapyramidal reactions.

What it is used for

  • Chemoprophylaxis against signs and symptoms of influenza A virus infection
  • Treatment of uncomplicated respiratory tract illness caused by influenza A, especially when given early
  • Parkinsonism
  • Drug-induced extrapyramidal reactions

Dosing

  • Influenza A, adults: 200 mg daily as a single dose, or split as 100 mg twice a day
  • Persons 65 years of age or older: 100 mg daily
  • Children 9 to 12 years: 200 mg daily given as 100 mg twice a day; younger children receive a weight-based dose with a daily maximum
  • Prophylaxis: at least 10 days after a known exposure; treatment should start as soon as possible, preferably within 24 to 48 hours of symptom onset
  • Dose may need reduction in congestive heart failure, peripheral edema, orthostatic hypotension or impaired renal function
  • Parkinsonism and renal-impairment dosing: see the full prescribing information

Contraindications

  • Known hypersensitivity to amantadine hydrochloride or any other ingredient

Important warnings

  • Deaths reported from overdose; toxicity may be cardiac, respiratory, renal or CNS
  • Deaths from drug accumulation in patients with renal impairment given higher than recommended doses
  • Suicide attempts have been reported
  • Dose caution in congestive heart failure, peripheral edema and orthostatic hypotension

Side effects

  • Most frequent (5 to 10%): nausea, dizziness (lightheadedness), insomnia
  • Less frequent: depression, anxiety, hallucinations, confusion, dry mouth, constipation, livedo reticularis, peripheral edema, orthostatic hypotension
  • Infrequent: congestive heart failure, psychosis, urinary retention, visual disturbance including corneal opacity
  • Rare: convulsion, leukopenia, neutropenia, suicidal ideation and suicide

Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.

Full official text →

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For patients

Patient information (US)

This product has no separate US patient information.

Authorisation and brand names by country

Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.

Austria

  • Pk-Merz-SchoellerMerz Pharma Austria Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Germany

  • Amantadin RatiopharmRatiopharm Gmbh · 1 register entry
  • Amantadin StadaStadapharm Gmbh · 1 register entry
  • Pk-MerzMerz Pharmaceuticals Gmbh · 2 register entries

Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28

Turkey

  • NeomidantanOLPHA İLAÇ VE TIBBİ ÜRÜNLER SAN. VE TİC. LTD. ŞTİ. · 1 register entry
  • Pk-MerzASSOS İLAÇ KİMYA GIDA ÜRÜNLERİ ÜRETİM VE TİC. A.Ş. · 4 register entries

Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16

Brand names in 23 more European countries
Bulgaria
Пк-Мерц
Croatia
Pk-Merz
Czechia
Pk-Merz, Viregyt-K
Denmark
Amypha, Dinetrel, Parkadin
Estonia
Amantadin Ratiopharm
Finland
Amypha, Parkadin
France
Mantadix
Greece
Symmetrel
Hungary
Pk-Merz, Viregyt
Ireland
Amantadine Hydrochloride Renata
Italy
Mantadan
Latvia
Neomidantan, Pk-Merz
Lithuania
Amantadin Ratiopharm, Pk-Merz
Luxembourg
Pk-Merz®
Malta
Amantadine Hydrochloride Renata, Parkadina
Netherlands
Amantadine Hcl Renata, Amypha, Symmetrel
Norway
Amypha, Dinetrel, Parkadin
Poland
Amantix, Viregyt-K
Portugal
Amantadina Renata, Amantadine Hydrochloride Renata Pharmaceuticals (Ireland), Parkadina
Romania
Viregyt-K
Slovakia
Pk-Merz, Viregyt-K
Spain
Amantadine Level
Sweden
Amypha, Dinetrel, Parkadin

EMA – Article 57 product data (EU/EEA), 2026-10-28

Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.

Another question about this substance?

Medelix answers clinical questions from guidelines, studies and product information – every claim with its source.

Sources

  1. U.S. Food and Drug Administration. amantadine hydrochloride (AvKARE) – Prescribing Information, 2026-06-17. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=547904f3-84a3-1ccb-e063-6294a90a6fb6
  2. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  3. EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
  4. TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
  5. Wikidata (CC0): ATC N04BB.

Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error

Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.