Allopurinol
Allopurinol !$tada, Allopurinol +pharma, Allopurinol Accord, Allopurinol Aristo · ATC code M04AA01
Brand names: Allopurinol !$tada, Allopurinol +pharma, Allopurinol Accord, Allopurinol Aristo, Allopurinol G.L., Allopurinol Genericon, Allopurinol Hexal, Allopurinol Retard Genericon, Allopurinol Sandoz, Allostad, Gichtex Retard, Purinol, Urosin, Allobeta, Allopurinol Abz …
- Key facts
- Active substance
- Allopurinol
- Drug class
- Antigout agent
- ATC code
- M04AA01
- Authorisation
- authorised nationally; no central EU authorisation
- Information as of
- 2026-10-27
Key facts
Allopurinol is a xanthine oxidase inhibitor that lowers uric acid production. Per the US prescribing information, it is used for gout, cancer-therapy-related hyperuricemia and recurrent calcium oxalate stones.
What it is used for
- Adults with primary or secondary gout (attacks, tophi, joint destruction, uric acid lithiasis, nephropathy)
- Adults and children with leukemia, lymphoma or solid tumors receiving cancer therapy that raises uric acid
- Adults with recurrent calcium oxalate calculi and high uric acid excretion despite lifestyle changes
- Not recommended for asymptomatic hyperuricemia
Dosing
- Gout: start at 100 mg daily, increase weekly by 100 mg until serum uric acid is 6 mg/dL or less
- Renal impairment: start at 50 mg daily with smaller increases (table in the full text)
- Minimal effective dosage 100 mg to 200 mg daily, maximum 800 mg daily; doses above 300 mg given in divided doses
- Mild gout usually 200 mg to 300 mg daily; moderate to severe tophaceous gout 400 mg to 600 mg daily
- Flare prophylaxis with colchicine or an anti-inflammatory agent is recommended at initiation
- Other regimens (cancer therapy, calculi) are in the full text
Contraindications
- History of hypersensitivity reaction to allopurinol or any ingredient
Important warnings
- Serious, sometimes fatal skin reactions (TEN, SJS, DRESS); discontinue permanently at first skin rash
- HLA-B*58:01 carriers are at higher risk of hypersensitivity; use not recommended unless benefits clearly outweigh risks
- Nephrotoxicity: monitor kidney function early in treatment
- Hepatotoxicity and myelosuppression may occur
- Possible effect on driving and use of machinery
Side effects
- Most frequent adverse reaction: skin rash
- Common (≥ 1%): diarrhea, nausea, increased alkaline phosphatase and AST/ALT, acute gout attacks
- Less common (< 1%): including fever, headache, vasculitis, pericarditis, bradycardia
Interactions
- Bendamustine, thiazide diuretics, ampicillin and amoxicillin may increase the risk of skin rash
- With thiazides and impaired renal function, monitor kidney function and reduce the dose
- Further clinically important interactions are in the full text
Pregnancy and breastfeeding
- Based on animal findings, may cause fetal harm; allopurinol and oxypurinol cross the placenta
Summary of the official product information, written with AI (Claude, Anthropic) on 2026-10-28. Every number was checked automatically against the original text. Not reviewed by a physician – the full official text is authoritative.
Common questions – ask Medelix
For patients
Patient information (US)
This product has no separate US patient information.
Authorisation and brand names by country
Medicines with exactly this active-substance composition, as listed in the national registers – alphabetical and without ranking. Whether a product is currently available is not shown here.
Austria
- Allopurinol !$tadaStada Arzneimittel Gmbh · 1 register entry
- Allopurinol +pharma+pharma Arzneimittel Gmbh · 1 register entry
- Allopurinol AccordAccord Healthcare B.V. · 1 register entry
- Allopurinol AristoAristo Pharma Gmbh (Art 57) · 1 register entry
- Allopurinol G.L.G.L. Pharma Gmbh · 1 register entry
- Allopurinol GenericonGenericon Pharma Gesellschaft M.B.H. · 1 register entry
- Allopurinol HexalHexal Pharma Gmbh · 1 register entry
- Allopurinol Retard GenericonGenericon Pharma Gesellschaft M.B.H. · 1 register entry
- Allopurinol SandozSandoz Gmbh · 1 register entry
- AllostadStada Arzneimittel Gmbh · 1 register entry
- Gichtex RetardG.L. Pharma Gmbh · 1 register entry
- PurinolTeva B.V · 1 register entry
Show all 13 brand names
- UrosinTeofarma S.R.L. · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Germany
- AllobetaBetapharm Arzneimittel Gmbh · 1 register entry
- Allopurinol AbzAbz-Pharma Gmbh · 1 register entry
- Allopurinol AlAliud Pharma Gmbh · 1 register entry
- Allopurinol AmaroxAmarox Pharma Gmbh · 1 register entry
- Allopurinol AristoAristo Pharma Gmbh (Art 57) · 1 register entry
- Allopurinol HeumannHeumann Pharma Gmbh & Co. Generica Kg · 2 register entries
- Allopurinol HexalHexal Ag · 1 register entry
- Allopurinol IndocoIndoco Remedies Czech S.R.O. · 1 register entry
- Allopurinol IpcaIpca Productos Farmaceuticos Unipessoal Lda · 1 register entry
- Allopurinol PurenPuren Pharma Gmbh & Co. Kg · 1 register entry
- Allopurinol RatiopharmRatiopharm Gmbh · 1 register entry
- Allopurinol StadaStadapharm Gmbh · 1 register entry
Source: EMA – Article 57 product data (EU/EEA), as of 2026-10-28
Turkey
- AllogutATABAY İLAÇ FABRİKASI A.Ş. · 1 register entry
- AllopinRECORDATİ İLAÇ SAN. VE TİC. A.Ş. · 3 register entries
- ÜrikolizSANDOZ İLAÇ SAN. VE TİC. A.Ş. · 2 register entries
Source: TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, as of 2026-10-16
USA
- AloprimMylan Institutional LLC · 1 register entry
Source: U.S. FDA – Drug labels (openFDA/DailyMed), as of 2026-10-28
Brand names in 26 more European countries
- Belgium
- Allopurinol Ab, Allopurinol Eg, Allopurinol Eurogenerics, Allopurinol Sandoz, Allopurinol Teva, Zyloric
- Bulgaria
- Алодагра, Милурит
- Croatia
- Alopurinol Belupo, Alopurinol Pharmas, Alopurinol Sandoz
- Cyprus
- Allopurinol Accord, Alopron, Zylapour, Zyloric
- Czechia
- Allopurinol Indoco, Allopurinol Medreg, Alopurinol Sandoz, Alopurinol Stada, Milurit, Purinol
- Denmark
- Allopurinol "sandoz", Allopurinol Accord, Allopurinol Eql Pharma, Allopurinol Medical Valley, Allopurinol Orion, Allopurinol Teva
- Estonia
- Allopurinol Accord, Allopurinol Auxilia, Allopurinol Orifarm, Allopurinol Sandoz
- Finland
- Allonol, Allopurinol Accord, Allopurinol Orion, Allopurinol Stada, Apurin, Zyloric
- France
- Allopurinol Arrow Lab, Allopurinol Biogaran, Allopurinol Cristers, Allopurinol Eg, Allopurinol Sandoz, Allopurinol Teva, Allopurinol Viatris, Allopurinol Zentiva, Zyloric
- Greece
- Soluric, Zylapour, Ζyloric
- Hungary
- Allopurinol Indoco, Milapur, Milurit
- Ireland
- Allopurinol Accord Healthcare Ireland, Allopurinol Clonmel, Allopurinol Teva, Alopur, Tipuric, Zyloric
- Italy
- Allopurinol Teva Italia, Allopurinolo Accord, Allopurinolo Adulti Doc Generici, Allopurinolo Doc Generici, Allopurinolo Eg Stada, Allopurinolo Molteni, Allopurinolo Mylan, Allopurinolo Sandoz, Allopurinolo Teva Italia, Allurit, Zyloric
- Latvia
- Allopurinol Accord, Allopurinol Orifarm, Allopurinol Sandoz, Milurit
- Lithuania
- Allopurinol Accord, Allopurinol Auxilia, Allopurinol Ratiopharm, Milurit
- Luxembourg
- Allopurinol Eg, Allopurinol Eurogenerics, Allopurinol Ratiopharm, Zyloric
- Malta
- Allopurinol, Alopron, Zyloric
- Netherlands
- Acepurin, Allopurinol Accord, Allopurinol Amarox, Allopurinol Aristo, Allopurinol Aurobindo, Allopurinol Cf, Allopurinol Pch, Allopurinol Sandoz, Alotab, Zyloric
- Norway
- Allopur, Allopurinol Medical Valley, Allopurinol Orion, Allopurinol Sandoz, Allopurinol Stada, Allopurinol Viatris, Zyloric
- Poland
- Adnamil, Allopurinol Aurovitas, Allopurinol Medreg, Allupol, Argadopin, Auricid, Dnor, Milurit, Ryzaron
- Portugal
- Allopurinol Ratiopharm, Alopurinol Ciclum, Alopurinol Generis, Alopurinol Ipca, Alopurinol Mylan, Alopurinol Sidefarma, Alopurinol Vida, Ikynol, Zurim, Zyloric
- Romania
- Alopurinol Arena, Alopurinol Gemax Pharma, Alopurinol Stada, Alopurinol Terapia, Milurit
- Slovakia
- Allopurinol Medreg, Allospes, Alopurinol Sandoz, Alopurinol Stada, Milurit
- Slovenia
- Alopurinol Belupo, Alopurinol Sandoz
- Spain
- Allopurinol Teva, Allorin, Alopurinol, Zyloric
- Sweden
- Allopurinol Accord, Allopurinol Medical Valley, Allopurinol Nordic Drugs, Allopurinol Orifarm, Allopurinol Orion, Allopurinol Sandoz, Allopurinol Teva, Allopurinol Viatris
EMA – Article 57 product data (EU/EEA), 2026-10-28
Medelix receives no money from pharmaceutical companies. Brand names are listed alphabetically and without ranking.
Other substances in the same group
Another question about this substance?
Medelix answers clinical questions from guidelines, studies and product information – every claim with its source.
Sources
- U.S. Food and Drug Administration. Allopurinol (Florida Pharmaceutical Products, LLC) – Prescribing Information, 2026-02-05. DailyMed (NLM), 2026-10-27. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=815af471-5985-4819-936d-1f5f3d871ef8
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- EMA – Article 57 product data (EU/EEA), 2026-10-28. https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/data-medicines-iso-idmp-standards-post-authorisation/public-data-article-57-database
- TİTCK – Ruhsatlı Beşeri Tıbbi Ürünler Listesi, 2026-10-16. https://www.titck.gov.tr/dinamikmodul/85
- U.S. FDA – Drug labels (openFDA/DailyMed), 2026-10-28. https://dailymed.nlm.nih.gov/dailymed/
- Wikidata (CC0): ATC M04AA.
Editorial: Medelix editorial team · last updated 2026-10-27 · How these pages are made · Report an error
Source: U.S. Food and Drug Administration (FDA), prescribing information, via DailyMed (NLM); public domain. Not advertising, not a treatment recommendation. For questions about your own treatment, ask your doctor or pharmacist.