Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
Global Pertussis Initiative (GPI) · 2022 · international
Source and licence
- Authors
- Bahaa Abu-Raya, Kevin Forsyth, Scott A. Halperin et al.
- Title
- Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
- Journal
- Vaccines, 2022
- Licence
- CC BY 4.0
- Changes
- Verbatim excerpts; formatting adapted
Full text retrieved 2026-10-27 from Europe PMC · PMC9786323
Licence statement of the original publication
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
This page reproduces excerpts of the original publication; the original is authoritative. It has not been reviewed by a physician, does not state a recommendation of Medelix and does not replace medical advice. The guideline may have been updated since.
Open the original publication →Full text on Europe PMC
Recommendations
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Abstract
Highlights: Vaccination against pertussis in pregnancy is safe for pregnant women and newborns.
Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants.
Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels.
Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant.
More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines.
Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk.
COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis.
Abstract: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.
Contents of the original publication
The section headings of the original.
- 1. Introduction
- 2. Immunobiology of Pertussis Vaccination in Pregnancy
- 3. Optimal Timing of Vaccination
- 3.1. Time-Dependent VE
- 3.2. Time-Dependent Immunogenicity
- 3.3. Time-Dependent Effect on Infant Immune Response
- 4. Modification of Infant Immune Response to Vaccination following Vaccination against Pertussis in Pregnancy
- 4.1. Effect on Immune Responses to B. pertussis Antigens in aP Vaccines
- 4.2. Effect on Immune Response to B. pertussis Antigens in wP Vaccines
- 4.3. Modification to DT and TT Antigens and Conjugated Vaccines
- 4.4. Mechanistic Insights into Modification of Immune Responses following Vaccination in Pregnancy
- 5. In Utero Exposure to Vaccine Antigens
- 6. Pertussis-Specific Antibodies in Breast Milk following Vaccination in Pregnancy
- 7. Effect of COVID-19 on Pertussis Detection and Immunity
- 8. Concluding Remarks
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