Italian guidelines on management of persons with multimorbidity and polypharmacy
ISS / Italian intersociety · 2022 · Italy
Source and licence
- Authors
- Graziano Onder, Davide Liborio Vetrano, Katie Palmer et al.
- Title
- Italian guidelines on management of persons with multimorbidity and polypharmacy
- Journal
- Aging Clinical and Experimental Research, 2022
- Licence
- CC BY 4.0
- Changes
- Verbatim excerpts; formatting adapted
Full text retrieved 2026-10-27 from Europe PMC · PMC9135855
Licence statement of the original publication
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
This page reproduces excerpts of the original publication; the original is authoritative. It has not been reviewed by a physician, does not state a recommendation of Medelix and does not replace medical advice. The guideline may have been updated since.
Open the original publication →Full text on Europe PMC
Recommendations
Verbatim, with grade of recommendation or strength of consensus where given.
Panel note to review Question 6
- Proton pump inhibitors should be deprescribed after a maximum treatment period of 6 weeks in persons who are treated for pyrosis, dyspepsia, or other symptoms of gastroesophageal reflux disease (in the absence of Barrett's oesophagus, severe esophagitis (grade C or D), documented history of gastrointestinal bleeding or other therapeutic indications such as long-term use of low-dose NSAIDs or aspirin in those at high-risk of bleeding) who have experienced an improvement in symptoms. New treatment with proton pump inhibitors may be considered if symptoms flare-up (i.e., on demand use).Strength of the recommendation: Strong.
Abstract
Multimorbidity and polypharmacy are emerging health priorities and the care of persons with these conditions is complex and challenging. The aim of the present guidelines is to develop recommendations for the clinical management of persons with multimorbidity and/or polypharmacy and to provide evidence-based guidance to improve their quality of care. The recommendations have been produced in keeping with the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Overall, 14 recommendations were issued, focusing on 4 thematic areas: (1.) General Principles; (2.) target population for an individualized approach to care; (3.) individualized care of patients with multimorbidity and/or polypharmacy; (4.) models of care. These recommendations support the provision of individualized care to persons with multimorbidity and/or polypharmacy as well as the prioritization of care through the identification of persons at increased risk of negative health outcomes. Given the limited available evidence, recommendations could not be issued for all the questions defined and, therefore, some aspects related to the complex care of patients with multimorbidity and/or polypharmacy could not be covered in these guidelines. This points to the need for more research in this field and evidence to improve the care of this population.
Contents of the original publication
The section headings of the original.
- Introduction
- Aims
- Methodology
- Expert panel
- Review questions
- General principles—Question 1
- Target population for an individualized approach to care—Questions 2 and 3
- Individualized care of patients with multimorbidity and/or polypharmacy—Questions 4–12
- Models of care – Question 13
- Literature review
- From evidence to recommendations
- Recommendations
- General principles
- Target population for an individualized approach to care
- Individualized approaches to care of patients with multimorbidity and/or polypharmacy
- Panel note to review Question 6
- Panel note to review Question 9
- Panel note to review Question 11
- Models of care
- Conclusion
A question about this guideline?
Medelix answers clinical questions from guidelines and studies – every statement with its source.
Are you the rights holder and object to this reproduction? Write to contact@medelix.ai and we will take the page down promptly. Imprint