Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper
ECCO · 2023 · Europe
Source and licence
- Authors
- Roger Feakins, Paula Borralho Nunes, Ann Driessen et al.
- Title
- Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper
- Journal
- Journal of Crohn's & Colitis, 2023
- Licence
- CC BY 4.0
- Changes
- Verbatim excerpts; formatting adapted
Full text retrieved 2026-10-27 from Europe PMC · PMC10896637
Licence statement of the original publication
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
This page reproduces excerpts of the original publication; the original is authoritative. It has not been reviewed by a physician, does not state a recommendation of Medelix and does not replace medical advice. The guideline may have been updated since.
Open the original publication →Full text on Europe PMC
Recommendations
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Abstract
Histological assessment of endoscopic biopsies in inflammatory bowel disease [IBD] plays an important role in clinical management, investigative studies, and clinical trials. Scoring schemes consisting of multiple histological items and offering considerable precision are widely available. However, definitions of histological abnormalities are often inconsistent. Furthermore, interobserver variability for their recognition and assessment may be high.
The European Crohn’s and Colitis Organisation [ECCO] formed an expert panel to explore definitions of histological abnormalities in IBD, with the aim of improving the quality of diagnosis and facilitating development of scoring schemes. The process confirmed that the current definitions often have no evidence base and vary between sources. Using available evidence and expert knowledge, the panel produced a series of ECCO consensus position statements on histological features in IBD.
Contents of the original publication
The section headings of the original.
- 1. Introduction
- 2. Materials and Methods
- 3. ECCO Positions
- 3.1. Architecture
- 3.2. Epithelium
- 3.3. Chronic Inflammation
- 3.4. Eosinophils
- 3.5. Granulomas
- 3.6. Acute inflammation
- 3.8. Distribution of abnormalities
- 3.9. Dysplasia
- 4. Discussion
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