Amyloid-beta antibody treatment in Alzheimer’s disease
Stögmann E, Schmidt R (Medizinische Universität Wien / Graz) · 2024 · Austria
Source and licence
- Authors
- Elisabeth Stögmann, Reinhold Schmidt
- Title
- Amyloid-beta antibody treatment in Alzheimer’s disease
- Journal
- Wiener Klinische Wochenschrift, 2024
- Licence
- CC BY 4.0
- Changes
- Verbatim excerpts; formatting adapted
Full text retrieved 2026-10-27 from Europe PMC · PMC11926045
Licence statement of the original publication
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Abstract
Amyloid-beta (Aβ) antibody treatment has emerged as a promising approach for the treatment of Alzheimer’s disease (AD), targeting the accumulation of Aβ plaques, which are a hallmark of the disease. This review provides an update on recent clinical trial data, highlighting the efficacy and safety of various antibodies targeting Aβ. Recent trials have demonstrated that certain Aβ antibodies can reduce amyloid plaques and slow cognitive decline in patients with early AD. Key findings from trials of drugs are discussed, including their mechanisms of action, dosing regimens, and observed side effects. The potential for Aβ antibody therapy to be integrated into routine clinical practice is also explored. While Aβ antibody therapy represents a significant advancement in AD treatment, ongoing research is needed to optimize their use and understand their long-term impact. This review underscores the importance of personalized medicine in AD and the need for continued innovation in therapeutic strategies.
Contents of the original publication
The section headings of the original.
- Introduction
- Lecanemab—The first anti-amyloid antibody with consistent positive results on biomarker and clinical endpoints
- Donanemab data provide further evidence
- Scepticism about varying clinical efficacy of amyloid-β antibodies in Alzheimer’s disease
- Recommendation for appropriate use
- Perspective of new therapeutic developments in AD therapy
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