Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia
European Journal of Clinical Nutrition · 2025 · Europe
Source and licence
- Authors
- Alfie Thain, Kathryn Hart, Kourosh R. Ahmadi
- Title
- Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia
- Journal
- European Journal of Clinical Nutrition, 2025
- Licence
- CC BY 4.0
- Changes
- Verbatim excerpts; formatting adapted
Full text retrieved 2026-10-27 from Europe PMC · PMC12274127
Licence statement of the original publication
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This page reproduces excerpts of the original publication; the original is authoritative. It has not been reviewed by a physician, does not state a recommendation of Medelix and does not replace medical advice. The guideline may have been updated since.
This is a review of another guideline (NICE NG239 Vitamin B12 deficiency in over 16s: diagnosis and management, NICE 2024). We do not reproduce that guideline's recommendations here – they belong to the original guideline.
Open the original publication →Full text on Europe PMC
Abstract
The 2024 NICE guidelines on vitamin B12 deficiency have significant implications for the diagnosis and management of pernicious anaemia (PA), the commonest non-dietary cause of such deficiency. This perspective discusses the guidelines in relation to PA itself, suggests that clearer diagnostic protocols are required, and calls for clinician education to improve the patient journey for those with PA.
Contents of the original publication
The section headings of the original.
- Introduction
- Renaming of pernicious anaemia as autoimmune gastritis
- Diagnosing PA: the commonest non-nutritional cause of vitamin B deficiency
- There are also several positives for PA patients from the 2024 NICE guidelines
- Conclusions
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